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MatD

What % of BP to use ?

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Dan's regimen says that a BP of 2.5% should be used. But since 2 years i hav been using a BP of 5%. so i wanted to know why 2.5 % and why not 5 % ???

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BPO's antibacterial activity does not increase with increasing dose, as the 2.5% formulation has a similar kill rate as the 10% formulation. (Kligman AM. Acne vulgaris: Tricks and treatments. Part II:The benzoyl peroxide saga. Cutis. 1995; 56:260-261). However, the potential for irritation does correlate to increasing dose, so ideally the concentration of BPO should be as low as possible (Tanghetti EA, Popp KF. A current review of topical benzoyl peroxide: New perspectives on formulation and utilization. Dermatol Clin. 2009; 27:17-24).

From the faq's on this site:

2.5% is best. However, anything up to 5% should most likely be fine, albeit more drying and no more effective. Avoid 10% preparations which will over dry. One exception is when dealing with pimples on the back. The skin in this area is tough and may withstand 10% nicely. If you can find a 10% much cheaper, feel free to try it on the back.

So why not simply use less of a 10% solution? Through trial and error I have found this does not work. I do not know exactly why using more of a 2.5% solution works better. My educated guess would be that when you use more of the product, there is more available to be absorbed into the skin.

If you've been using 5% for so long and your skin can handle it, then I don't see a problem.

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