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Been on Retina micro .1% for over a year

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I've been on retina micro .1 entire year, I have been FINALLY CLEAR for 4 months. I am taking zinc 100mg and vit B5 2500mg during entire time to take care if excess sebum production. So far ALL WORKED FOR ME..! My diet and the weather are all the same, so no sudden changes. Until yesterday AFTERNOON.... early in the morning I have NO PIMPLES, but at 5 pm one pimple came out of nowhere...and it grew to a painful almost like a cyst.! People wondered what happened cuz last 8 hrs ur skin was flawless and now a huge one popped out..! The only difference is my last 3days I've been working almost 15 hrs and not getting much rest. Can ANYONE chime in? I hope I'm not developing a retina resistance now!!! That'll such for sure. I'm 37yr old male. So I know it's not puberty!!

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