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Can you build immunity to a retinoid?

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I'm assuming by "immunity" you mean "resistance"? We *think* retinoids work mainly by hitting retinoid receptors. Is it plausible that the body could develop resistance by reducing the number of receptors or regulating the strength of the response? Yes. Realistically? No. Retinoid receptors are too important.

Retinoids certainly won't stop working in the way that some antibiotics do - the mechanism there is that the bacteria mutate and develop resistance. Retinoids do not directly affect bacteria.

So to answer your question, a retinoid should always work for you if it worked once.

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