Jump to content
Acne.org
Search In
Find results that contain...
Find results in...
lk5287

A miracle drug for scar reduction - Fluorouracil

Recommended Posts

Did anyone else see the coverage of the drug Fluorouracil the last few days? It's a skin cancer drug that, when taken for two weeks, stimulates substantial collagen production. In a recent study, just about every participant had a MASSIVE improvement in their skin -- wrinkles disappeared, spots disappeared. Apparently, the skin quality became that of someone decades younger after just a couple of weeks of treatment. I'm thinking it could be a great option for acne scarring.

If you want to learn more about it, go to google news and put in Fluorouracil and you'll see a ton of articles written about it during this last week.

Share this post


Link to post
Share on other sites

You're making an exageration :think:

This study is small. But fluorouacil certainly makes some difference.

Topical Fluorouracil Useful for Actinic Keratoses and Photoaging

NEW YORK (Reuters Health) Jun 15 - Twice daily treatment with fluorouracil cream can significantly improve actinic keratoses and photoaging, according to a report in the Archives of Dermatology for June.

"The mechanism of topical fluorouracil follows a predictable wound healing pattern of events reminiscent of that seen with laser treatment of photoaging," Dr. Dana L. Sachs, from the University of Michigan, Ann Arbor, and colleagues write.

In the study, 21 healthy subjects, 56 to 85 years of age, with actinic keratoses and photodamage were treated with topical fluorouracil 5% for 2 weeks. Biopsies and clinical evaluation were performed at baseline and then regularly after treatment.

As noted, treatment with topical fluorouracil improved actinic keratoses and photoaging and most patients said they were willing to undergo treatment again.

At a molecular level, fluorouracil treatment was associated with an increase in expression of genes involved in epidermal injury (keratin 16), inflammation (interleukin-1beta), and extracellular matrix degradation (matrix metalloproteinases 1 and 3). Levels of procollagen mRNA and procollagen itself were also increased.

"It is likely that other topical agents such as diclofenac gel or imiquimod that have similar skin-injuring properties in photodamaged skin may have a similar restorative effect," the authors note.

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


  • Personalized Advice Quiz - All of Acne.org in just a few minutes

×