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immune to minocycline a year ago...will it work again now??

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i was on minocycline for a year starting 2 years ago, it worked brilliantly but after about a year it started to become less effective. ive now had a year off it and have tried lymecycline, doxycycline since, if i went back on minocycline now is it likely to be ineffective or should it work well again as ive not been on it in over a year? thanks

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