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Bulgarian R.

Stem Cells for Acne Scar Repair (SCIENCE FACT, not science fiction!)

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Btw, I haven't recieved a reply from the American stem cell center, yet. I'm going to give them another couple of days. And if they still haven't replied by then I might call them on the phone.

I've gotten a reply. :)

Yesterday I had sent an e-mail their way with a couple of questions. Among some other things, I asked what patients can expect from the procedure; if the treatment solely improves the appearance of scars by filling them in and "remodelling some fibrous tissue" or if it actually reconstructs the epidermis. I also asked what the costs are of the treatment. Here's what they said:

They use a stem cell serum which consists out of 130 different proteins and growth factors which are extracted from the stem cell. They say they are "one of the first to perform this procedure".

The treatment "completely restores the skin the stem cell serum becomes your new skin cells". The skin is "smooth and free of acne scars".

The first visit is $700 and the subsequent two, to a maximum of four are $550 each. A total of five visits are the norm. So that sums up to $2900 at the most for the entire thing.

So there you go. That's what they said. Do you guys agree with me that this sounds different in the sense that they apparently don't inject the stem cells themselves? Which is what I thought was the whole point? Also, what they claim is the case, regarding the skin being completely restored... It would be wonderful but on so many websites I've read things like "There are no cures yet. The only thing stem cell treatments can do at the moment is improve a person's condition to a degree". So it conflicts with those things I've read. But those things may have been only regarding diseases like MS and such. Not regarding scars/wounds. I'm not 100% on that.

Anyway, I'm going to do a short follow up on the e-mail I sent yesterday, so I'll let you know if they said anything else that's interesting.

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Does any one know of valveta?

Any one tried it

That's the first time I've heard of it.

http://www.vavelta.com/vavelta/

I'm sure it'll have some kind of positive effect but it looks like they're fibroblasts that come from other people than yourself. And that's kind of off-putting to me. :confused:

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Thanks for relaying that info, I Do Not Have Acne. I've been following this thread very closely and was thinking of e-mailing that stem cell clinic in Texas myself. The people that you e-mailed: was that the clinic in Texas or in Washington?

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I e-mailed the one in Washington:

http://longevityskinandlaser.com/

Kathy Painter answered my questions. Who writes in blue which is really cool. lol :)

Anyway, I said I'd do a short follow up but I decided to basically just reply back to her with "Thanks for your swift reply". Because I didn't want to come across like a nuisance and I basically had gotten answers to all the questions I had, so..

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Thanks. I've been meaning to e-mail the other one with some questions. No time like the present I guess.

I e-mailed the one in Washington:

http://longevityskinandlaser.com/

Kathy Painter answered my questions. Who writes in blue which is really cool. lol :)

Anyway, I said I'd do a short follow up but I decided to basically just reply back to her with "Thanks for your swift reply". Because I didn't want to come across like a nuisance and I basically had gotten answers to all the questions I had, so..

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I noticed on the site, that for Chicken Pox scars it says that it can only be improved. Since I got lots of deep acne scaring, that's what I'd imagine my results to be like.

Good to see this "Stem Cell" therapy spreading to the United States. We'll now have lots of results and information!

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I noticed on the site, that for Chicken Pox scars it says that it can only be improved. Since I got lots of deep acne scaring, that's what I'd imagine my results to be like.

Good to see this "Stem Cell" therapy spreading to the United States. We'll now have lots of results and information!

where did you hear that stem cells can't completely restore chicken pox scars.

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I noticed on the site, that for Chicken Pox scars it says that it can only be improved. Since I got lots of deep acne scaring, that's what I'd imagine my results to be like.

Good to see this "Stem Cell" therapy spreading to the United States. We'll now have lots of results and information!

where did you hear that stem cells can't completely restore chicken pox scars.

It just says on this site: "Improve chicken pox scars" Of course it also says "Fill acne scarring". But my acne scarring is considered very deep.

http://longevityskinandlaser.com/Stem%20Ce...%20Revision.htm

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I came across another clinic, called 'Stem cells for hope'.

http://www.stemcellsforhope.com/index.htm

They offer treatments in America (New York), Georgia (Tbilisi), Mexico (Tijuana) and Ukraine (Kiev).

I've read about this clinic on Forbes.com. On their site is a list with conditions that are currently being treated and one of them is skin regeneration. They don't have any prices on their website, though. They only say it differs from patient to patient. But I've read somewhere that people who have gotten treated there for MS have payed $25.000 to $35.000. A scar/skin treatment will be a lot less, I think. Probably around the same amount as the other clinics that were mentioned charge.

Also, check out this forum:

http://www.stemcellsforhope.org/

Among other things, they've got a section where people can share their experiences with treatments. It could be interesting.

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I noticed on the site, that for Chicken Pox scars it says that it can only be improved. Since I got lots of deep acne scaring, that's what I'd imagine my results to be like.

Good to see this "Stem Cell" therapy spreading to the United States. We'll now have lots of results and information!

where did you hear that stem cells can't completely restore chicken pox scars.

It just says on this site: "Improve chicken pox scars" Of course it also says "Fill acne scarring". But my acne scarring is considered very deep.

http://longevityskinandlaser.com/Stem%20Ce...%20Revision.htm

Yeah, it's weird that it says that on their site. Especially seeing that in the e-mail I received they said the skin is completely restored by the serum.

But even if it solely improves chicken pox scars, I figure it will do so to a significant degree.

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Reading a little further into the link you posted: http://longevityskinandlaser.com/Stem%20Ce...%20Revision.htm

It sounds like it has nothing to really do with stem cells, sounds a lot like dermarolling or needling in which you injure the area and let your own bodies stem cells regenerate the wound. I dont know for sure but ill email to make sure. If stem cells are actually used or injected into the face then that would be a procedure worth looking at.

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Reading a little further into the link you posted: http://longevityskinandlaser.com/Stem%20Ce...%20Revision.htm

It sounds like it has nothing to really do with stem cells, sounds a lot like dermarolling or needling in which you injure the area and let your own bodies stem cells regenerate the wound. I dont know for sure but ill email to make sure. If stem cells are actually used or injected into the face then that would be a procedure worth looking at.

Yeah they use a serum consisting of growth factors and an extract of adipose-derived stem cells. It isn't exactly the same as the stem cells themselves being injected into the face.

But nevertheless, they claim that it completely restores the skin. Personally, I doubt that sincerely. But I do think it'll probably do a lot of good.

Btw, I don't know if they retrieve the stem cells they use, from the patients themselves or if the serum is a ready to use product they purchase somewhere. My guess would be the latter. The information they have on their site kind of points in that direction. For instance, this:

"This is probably the most advanced Aesthetic product in the world, which is comprised of Stem Cell extract and growth factors in high concentrations."

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Btw, I don't know if they retrieve the stem cells they use, from the patients themselves or if the serum is a ready to use product they purchase somewhere. My guess would be the latter. The information they have on their site kind of points in that direction.

Also, because in the reply to the e-mail I sent recently I asked if they multiplied the stem cells themselves. And she didn't answer that specifically. She only said (paraphrased) "We use a stem cell serum" in the reply, so..

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Hello Guys!

I just recently joined acne.org "officially" tonight although I've been visiting for many years. Consequently, I've been following this particular thread for several months (without posting), which is why I decided to join tonight. During undergrad, I majored in biomedical sciences and was very intrigue with stem cell research even then. I want to commend each and every last one of you guys for your research and due-diligence concerning the matter especially the person who posted the topic. There is hope at the end of the tunnel for all acne suffers.

Any hoo….here is a website that I ran across which I wanted to share. This particular center is located outside of Dallas, TX. I’m currently attempting to get in touch with the owner to ascertain additional information regarding her procedures. I will keep you guys posted!

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Welcome Jay2008 to the forum, i just starting re-posting after a year. Keep us updated.

I've done many procedures with positive and negative outcomes and have had improvement. anyways, Idonthaveacne i would be weary about stem cell serums, sounds like marketing at its best. Its pretty much dermarolling and putting a serum on ur face for a lot of money. You can pretty much do the same thing at home for a tenth of the cost i.e http://www.stemcellskincare.com/Stem_Cell_..._Care_Serum.htm and buying a dermaroller off ebay or amazon. I have a dermaroller and just bought the serum, i dont expect much but ill try it anyways. Ill keep you updated, i have several doctor appt.'s in hopes in getting a product called Acell which is an ECM. I feel its the best product out right now in the U.S, so im going to give it a try as well, its just really hard to get a prescription for it :/. Best of luck, and i hope stem cell technology becomes more common in the states to consumers.

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Welcome Jay2008 to the forum, i just starting re-posting after a year. Keep us updated.

I've done many procedures with positive and negative outcomes and have had improvement. anyways, Idonthaveacne i would be weary about stem cell serums, sounds like marketing at its best. Its pretty much dermarolling and putting a serum on ur face for a lot of money. You can pretty much do the same thing at home for a tenth of the cost i.e http://www.stemcellskincare.com/Stem_Cell_..._Care_Serum.htm and buying a dermaroller off ebay or amazon. I have a dermaroller and just bought the serum, i dont expect much but ill try it anyways. Ill keep you updated, i have several doctor appt.'s in hopes in getting a product called Acell which is an ECM. I feel its the best product out right now in the U.S, so im going to give it a try as well, its just really hard to get a prescription for it :/. Best of luck, and i hope stem cell technology becomes more common in the states to consumers.

The creme vs the actual therapy are much different, and would probably yield different results. Also, the creme claims to use skin stem cells while most physician performed procedures use ADSC's.

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Hello Guys!

I just recently joined acne.org "officially" tonight although I've been visiting for many years. Consequently, I've been following this particular thread for several months (without posting), which is why I decided to join tonight. During undergrad, I majored in biomedical sciences and was very intrigue with stem cell research even then. I want to commend each and every last one of you guys for your research and due-diligence concerning the matter especially the person who posted the topic. There is hope at the end of the tunnel for all acne suffers.

Any hoo….here is a website that I ran across which I wanted to share. This particular center is located outside of Dallas, TX. I’m currently attempting to get in touch with the owner to ascertain additional information regarding her procedures. I will keep you guys posted!

Hi Jay. Looking forward to hearing what the clinic said. :)

Idonthaveacne i would be weary about stem cell serums, sounds like marketing at its best. Its pretty much dermarolling and putting a serum on ur face for a lot of money. You can pretty much do the same thing at home for a tenth of the cost i.e http://www.stemcellskincare.com/Stem_Cell_..._Care_Serum.htm and buying a dermaroller off ebay or amazon. I have a dermaroller and just bought the serum, i dont expect much but ill try it anyways. Ill keep you updated, i have several doctor appt.'s in hopes in getting a product called Acell which is an ECM. I feel its the best product out right now in the U.S, so im going to give it a try as well, its just really hard to get a prescription for it :/. Best of luck, and i hope stem cell technology becomes more common in the states to consumers.

I wasn't planning on getting treated with a serum. Like I said earlier; it isn't really the same as the thing BRD spoke of in the first post. Thanks for the concern, though. :)

Anyway, good luck with your serum experiment! And I can see Acell doing a lot of good. That's what they used to regrow a man's fingertip, right? I hope you can get some and that it does what you hope it will.

what are the odds that this technology is available in Europe?

Like is mentioned earlier in the thread, there's a clinic in Germany (XCell). But I think they only treat degenerative diseases. And then there are clinics in Tsiblisi and Kiev (both of the company StemCellsForHope) which both offer skin regeneration treatments, as far as I know. But I think the costs of getting treated in those latter two clinics are astronomical ($25000 - $35000).

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New article in "Nature" explains how scientists are one step closer to regenerating limbs: http://www.nature.com/news/2009/090701/ful...s.2009.614.html

Salamander cells remember their origins in limb regeneration

Cell tracking shows that axolotl cells in a regrowing leg retain distinct roles.

The amazing axolotl - legless, but never for long.Wikimedia CommonsSalamanders have the ability to regrow amputated limbs – but what stops a tail growing from the stump, instead of a leg?

A team of scientists are now a step closer the answer. They studied tissue regeneration in axolotls (Ambystoma mexicanum), salamanders endemic to Mexico. The creatures heal so well because the muscle, bone and skin cells nearest to the amputation site revert into a more generic form, forming a clump of adult stem cells called a blastema. These cells then divide and differentiate into the tissue types needed to make a new limb.

One possible explanation was that these undifferentiated blastema cells — which all look identical — are pluripotent and thus able to form many different cells types. But it was not clear how the original cells from adult tissue were reprogrammed, or how the blastema cells went on to form the correct tissue types.

"Everyone, including us, wanted to know how cells from the adult tissues are reprogrammed to make these blastema stem cells," says Elly Tanaka, a cell biologist at the University of Technology in Dresden, Germany, and part of the team.

Take one axolotl

The researchers first added a section of DNA to an axolotl so that it expressed green fluorescent proteins throughout its body. Then they transplanted cells from this animal into a normal axolotl, whose leg they amputated.

Only Schwann cells (green) wrap around the nerve fibers in the axolotl's regenerated limb.D.Knapp/E.TanakaAs the axolotl regrew its limb, the team tracked the fluorescent proteins to see what happened to each cell type. Despite going through a blastema stage and dividing, the muscle cells did not turn into any other types of tissue. The same was true of Schwann cells, which form a protective sheath around nerve cells. However, other tissue types were more flexible, with dermis cells also able to differentiate into cartilage tissue, but not muscle. The results are reported in Nature1.

The team also grafted cartilage and Schwann cells from the tip of a limb onto the upper arm of an amputated axolotl. They found that the cartilage cells moved to their old location in the newly-formed replacement limb, whereas the Schwann cells were more widely distributed.

Previous research had shown that blastema from different tissues behaves distinctly despite the uniform appearance of the cells, says Jeremy Brockes, a cellular and molecular biologist at University College, London. But those experiments were not able to track the blastema cells in such detail, he adds. They also relied on using cell in cultures, rather than directly grafting them from one animal to another, which may have interfered with the cells' behaviour, Tanaka suggests.

Researchers will need to learn much more about which molecular signals control blastema cells if they want to adapt the salamander's tricks for therapies in humans, says Tanaka. For example, using the fluorescent protein marker, she hopes to track when particular genes are activated during salamander regeneration, and she is optimistic that regenerating mammal limbs "may eventually be possible".

It is important to discover how molecular signals tell a cell that its neighbouring tissue has been cut off, and what triggers the regeneration process, says Brockes. Following cells during regeneration is a start, but "there's an enormous amount to learn", he says.

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Hi guys, I haven't posted on these boards for a long time but I just thought I should share my thoughts on this topic.

I've had PRP done back last December. The doctor took some of my blood and extracted the platelets out of it, injected the solution along with a bit of calcium back into my scarring. After that he used a 1.5mm dermaroller over the area a few times. I was slightly bruised for about 5 to 7 days, afterward you would not know I had anything done.

In the first 2 months I didn't have much improvement. My scars looked slightly more plumped but that is probably from the rolling.

By April near the end of May the redness in the scars and also the depth of all the scarring has lessen to a good 30 to 40%.

Fast forward to June, compared to some of the pics taken before, my scarring and discoloration has improved quite a lot. I would say somewhere near the number of 50%. I had one extra dermarolling combined with laser genesis during April and that must have contributed a little bit to the current results.

I was told that PRP varies a lot for each person. Some will not respond to it, while others will show good results very quickly. For me it took a few months. It was expensive but it was worth every penny. Now for the final bit of scarring and discoloration I can probably just do some sort of very light non-ablative laser with dermarolling and have the improvement that I was always looking for.

So if Stem Cells will one day be used for scarring, I wouldn't have a doubt in my mind that it will work better than any treatments that have been used in the past.

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I e-mailed StemCellsForHope the other week with a number of questions. And I got this reply with a standard file which had a bunch of stuff that's pretty much also on their website. But at the end of it, there was a direct phone number of someone called Peter Sidorenko who works there.

It said I could call him any time to ask about the treatments they offer. And about what other clinics in the world are doing right now with stem cells. So I'm probably going to call him this week.

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Hi guys, I haven't posted on these boards for a long time but I just thought I should share my thoughts on this topic.

I've had PRP done back last December. The doctor took some of my blood and extracted the platelets out of it, injected the solution along with a bit of calcium back into my scarring. After that he used a 1.5mm dermaroller over the area a few times. I was slightly bruised for about 5 to 7 days, afterward you would not know I had anything done.

In the first 2 months I didn't have much improvement. My scars looked slightly more plumped but that is probably from the rolling.

By April near the end of May the redness in the scars and also the depth of all the scarring has lessen to a good 30 to 40%.

Fast forward to June, compared to some of the pics taken before, my scarring and discoloration has improved quite a lot. I would say somewhere near the number of 50%. I had one extra dermarolling combined with laser genesis during April and that must have contributed a little bit to the current results.

I was told that PRP varies a lot for each person. Some will not respond to it, while others will show good results very quickly. For me it took a few months. It was expensive but it was worth every penny. Now for the final bit of scarring and discoloration I can probably just do some sort of very light non-ablative laser with dermarolling and have the improvement that I was always looking for.

So if Stem Cells will one day be used for scarring, I wouldn't have a doubt in my mind that it will work better than any treatments that have been used in the past.

Wow, that's very interesting. Someone else on here has had PRP as well, iirc. But as far as I know he's remaining silent about the outcome, even when people ask him about it. :think: It probably was a let down. Or I missed a few of his posts. lol That's also possible. ;)

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