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sallytomato

Forced to quit after 1 month. :(

What # do you guys get on your ALT liver function test while you are on Tane? Is 130-ish considered too high cos my derm told me to stop here and said 70s or below is what he's looking for. He told me to see my family doctor. If my family doctor says it's OK, then he'll more than happy to prescribe Tane again. :(

My skin is pretty clear now and I wonder how long that would last after 1 month of Tane.

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130 is high, considerably above the 'normal' range.

ALT values from Yale University

Blood (Plasma, Serum) All ages 0 - 35 U/L

The ALT is one of the tests that shows liver damage. It can be confounded by strenuous exercise prior to the test (perhaps in the last 24 hours even). I don't remember if one has to fast for it, but I think fasting is the norm for a hepatic function panel.

Here's a great link:

http://www.hepfi.org/living/liv_caring.html

Basic Liver Care

Your liver depends on you to take care of it . . . so it can take care of you. It serves as your body's engine, pantry, refinery, food processor, garbage disposal, and "guardian angel." The trouble is, your liver is a silent partner; when something's wrong it does not complain until the damage is far advanced. So it needs your help every day to keep it healthy and hepatitis-free. To do that, you need to eat a healthy diet, exercise, get lots of fresh air, and avoid things that can cause liver damage.

What does my liver do?

Sadly, people generally have little knowledge of the complexities and importance of the thousands of vital functions their livers perform nonstop.

The liver is about the size of a football – the largest organ in your body. It plays a vital role in regulating life processes. Before you were born, it served as the main organ of blood formation. Now, its primary functions are to refine and detoxify everything you eat, breathe, and absorb through your skin. It is your body's internal chemical power plant, converting nutrients in the food you eat into muscles, energy, hormones, clotting factors and immune factors.

It stores certain vitamins, minerals (including iron) and sugars, regulates fat stores, and controls the production and excretion of cholesterol. The bile, produced by liver cells, helps you to digest your food and absorb important nutrients. It neutralizes and destroys poisonous substances and metabolizes alcohol. It helps you resist infection and removes bacteria from the blood stream, helping you to stay healthy. Arguably, your liver isn't just your silent partner – it's your best friend.

Three things to avoid for liver health:

1 Avoid excessive alcohol.

Most people know that the liver acts as a filter and can be badly damaged by drinking too much alcohol. Liver specialists suggest that more than two drinks a day for men – and more than one drink a day for women – may even be too much for some people.

One of the most remarkable accomplishments of this miraculous organ is its ability to regenerate. (Three quarters of the liver can be removed and it will grow back in the same shape and form within a few weeks!) However, overworking your liver by heavy alcohol consumption can cause liver cells (the "employees" in the power plant) to become permanently damaged or scarred. This is called cirrhosis.

2 Avoid drugs and medicines taken with alcohol.

Medicines – especially the seemingly harmless acetaminophen (the active ingredient in Tylenol and other over-the-counter medications) – should never be taken with alcoholic beverages. Many prescribed and over-the-counter drugs and medicines (including herbal medications) are made up of chemicals that could be potentially hazardous to your precious liver cells, especially taken with alcohol.

If you are ill with a virus or metabolic disorder, liver damage may result from the medications you take. In such cases, you should ask your physician about possible liver cell damage.

3 Avoid environmental pollutants.

Fumes from paint thinners bug sprays, and other aerosol sprays are picked up by the tiny blood vessels in your lungs and carried to your liver where they are detoxified and discharged in your bile. The amount and concentration of those chemicals should be controlled to prevent liver damage. Make certain you have good ventilation, use a mask, cover your skin, and wash off any chemicals you get on your skin with soap and water as soon as possible.

Diet and Your Liver

Overview

Poor nutrition is rarely a cause of liver disease, but good nutrition in the form of a balanced diet, may help liver cells damaged by hepatitis viruses to regenerate, forming new liver cells. Nutrition can be an essential part of treatment. Many chronic liver diseases are associated with malnutrition.

Watch the Protein

To quickly determine your daily protein in grams, divide your weight in pounds by 2. Too much daily protein may cause hepatic encephalopathy (mental confusion). This occurs when the amount of dietary protein is greater than the liver's ability to use the protein. This causes a build up of toxins that can interfere with brain function. Protein is restricted in patients with clinical evidence of encephalopathy. However, controversy exists regarding the type of protein a diet should contain. Vegetable and dairy protein may be tolerated better than meat protein. Medications, such as lactulose and neomycin, may be used to help control hepatitis-related encephalopathy. Due to the body's need for proteins, protein restriction should only be undertaken with a doctor's advice.

Watch the Calories.

Excess calories in the form of carbohydrates can add to liver dysfunction and can cause fat deposits in the liver. No more than 30% of a person's total calories should come from fat because of the danger to the cardiovascular system. To figure out your daily calorie needs, you'll need a minimum of 15 calories a day for each pound you weight. Watch the Salt Good nutrition also helps to maintain the normal fluid and electrolyte balances in the body. Patients with fluid retention and swelling of the abdomen (ascites), or the legs (peripheral edema), may need diets low in salt to avoid sodium retention that contributes to fluid retention. Avoiding foods such as canned soups and vegetables, cold cuts, dairy products, and condiments such as mayonnaise and ketchup can reduce sodium intake. Read food labels carefully as many prepared foods contain large amounts of salt. The best-tasting salt substitute is lemon juice.

Watch Vitamins A and D

Excessive amounts of some vitamins may be an additional source of stress to the liver that must act as a filter for the body. Mega-vitamin supplements, particularly if they contain vitamins A and D, may be harmful. Excess vitamin A is very toxic to the liver.

Beware of Alcohol

You'll need to stop drinking completely to give your liver a break - a chance to heal, a chance to rebuild, a chance for new liver cells to grow. This means avoiding beer, wine, cocktails, champagne, and liquor in any other form. If you continue to drink, your liver will pay the price, and if your doctor is checking your liver function tests, it may be hard to determine if a change in a test means there has been damage to your liver due to the disease itself or because of the alcohol.

Beware of Alcohol and Acetaminophen

Acetominophen is an ingredient in some over-the-counter pain relievers, and is contained in many over-the-counter drugs used for colds or coughs. Taken with alcohol, these products can cause a condition called sudden and severe hepatitis which could cause fatal liver failure. Clearly, you should never combine these two substances. If you have any doubt about what medicines to take simultaneously, ask your doctor.

Beware of "Nutritional Therapies"

Herbal treatments and alternative liver medicines need to undergo rigorous scientific study before they can be recommended. "Natural" or diet treatments and herbal remedies can be quite dangerous. Plants of the Senecio, Crotalaria and Heliotopium families, plus chaparral, germander, comfrey, mistletoe, skullcap, margosa oil, mate tea, Gordolobo yerba tea, pennyroyal, and Jin Blu Huan are all toxic to the liver.

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Mine never got above the 30 mark either in the 6 months I was on it. A recent liver enzyme tests also revealed all is still normal.

130 is a MASSIVE spike in your liver function and I would seriosuly question EVER going back on it, given the all clear or not. Just imagine if you went another month without a blood test whilst on your course and your liver suffered irreversible damage.

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I have also been asked by my derm to stop accutane. I was finishing my third month and was about 70% of the treatment.

my AST is 93 out of the 5-30 IU/L range and

my ALT is 96 out of the 7-56 IU/L range

My derm asked me to have another blood test in 3 weeks to see if my liver enzymes levels go down.

:(

R

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My labs were pretty high today but my ALT was not out of range however it did go up it went from 14 to 20... It seems you should contact ur dr.

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For some reason, my ALT is consistently over 100 at my derm's even BEFORE Tane. I took the same test at my family doctor's around the same time frame and it was within the normal range at 60 something (normal = 21 to 72). I showed my derm the family doctor's ALT result and that was how I got my Tane from the derm. So I'm wondering if different labs use different testing methodology to get the results. Can a family doctor prescribe Tane?

I haven't had a breakout for 2 weeks and my face is really clearing up big time. The oiliness is gone and I'm liking it very much. So how long will this stay after going cold turkey? I had 1200mg of Tane total so far (30 x 40mg).

P.S. I've been drinking 3-5 cups of coffee a day lately. Does it have anything to do with the elevated ALT? I drink lots of water (min 1 gallon a day) to keep myself hydrated though.

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What's the next best topical alternative to Tane? GC, BHA? I got 2 new cysts today and I'm depressed. You see it's more dangerous when they take Tane away from you. :(

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I'm sorry, hun. :( Retinoids work a little bit like Tane, as far as purging goes. That'd probably be a good line of treatment to try in the meantime.

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How long will the decrease in oil production continue after I stopped Tane? I'm off Tane almost 1 week now and my face is still pretty much oil-free.

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