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How important is the cumulative dose?

I am just wondering how important is the cumulative dose or is it just some guidelines. For somebody who weights 50 kgs, the dose was calculated at 40 mgs daily for 150 days. What happens if half way through that course, that person now weighs 52 kgs? Should she be on the accutane a bit longer e.g an extra 6 days. Has it ever happened to anybody who has either lost or gain weight during the course of their treatment? If so, does the dosage needs to be adjusted? Thanks

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No I don't think so. U'r supposed to be on this drug till u'r clear, not when ur cumulative dosage is full (wel... if u'r going way too over u may be taken off).

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the cumulative dose (120mg/KG) is not a magical number nor is it a golden ticket to complete remission. It's just a number put together by statistics to give you a rough idea on what's needed for the greatest chance of remission.

In another word, acne can still come back even if you manage to hit the target, it's all draw of the straws...

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