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AutonomousOne1980

An argument for existence of alternative cures

what we already know:

Accutane can reverse acne in many cases, this means that whatever genes that are involved that encourage abnormal cell cycles, can be corrected. Problem is accutane has crazy side effects and isnt very safe and not effective in every case.

if there was enough studies done on how accutane works, then found other substances that would achieve the same effect, which HAVE to exist there is always more then one way to skin a cat, at least i believe there to be.

i took this illustration from a study that narrowed the immediate genes in acne to be nf kappa b and once these are activated they produced something called cytokines that have a feedback effect on the cells and keep these genes activated. these same genes are also believed to be the cause of most inflammatory diseases and nf-kappa b inhibitors are being now highly sought after by researchers and pharma companies.

http://i221.photobucket.com/albums/dd54/wi...280/diagram.jpg

caption for corresponding illustration-

Hypothetical model of the pathophysiology of inflammatory acne and dermal damage. In inflammatory acne lesions, NF-κB signaling is activated. As a consequence, NF-κB-driven inflammatory cytokine genes (eg, TNF-α and IL-1β) are induced. These primary cytokines will propagate the inflammatory response by acting on endothelial cells to elaborate adhesion molecules (eg, ICAM-1) to facilitate recruitment of inflammatory cells into the skin. TNF-α and IL-1β will also stimulate the production of secondary cytokines, such as IL-8, which can aid in chemotaxis of inflammatory cells. By working through their cell surface receptors, TNF-α and IL-1β not only amplify the NF-κB signaling cascade, but also activate MAP kinases to stimulate AP-1-mediated gene transcription. As a consequence of AP-1 activation (cJun induction), AP-1-driven MMPs are elaborated by resident skin cells. Along with MMP-8 and neutrophil elastase brought in by PMNs, they degrade the matrix. This is followed by matrix synthesis and repair, which is imperfect. Most of the imperfections would leave clinically undetectable deficits in the organization or composition, or both, of the extracellular matrix. However, when they occur to a significant extent throughout time, accompanied by sustained procollagen synthesis, acne scarring becomes clinically visible.

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There is no plant jaffa is aware of that holds any resembelance to accutane.And he has been searching forever.Burdock,Aloe and dandelion taken internally have very good affects similiar to accutane but no vit a derivative. :ninja:

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There is no plant jaffa is aware of that holds any resembelance to accutane.And he has been searching forever.Burdock,Aloe and dandelion taken internally have very good affects similiar to accutane but no vit a derivative. :ninja:

search for nf kappa b inhibitors or down regulators.

im starting a list fo my own, gathered from various studies.

Glutathione

Caffeic Acid Phenethylester

aspirin

sulphorophane

Piperine

Incensole acetate, an anti-inflammatory compound isolated from Boswellia resin

NAC

myricetin one of the major flavonols in red wine

nothing is guaranteed and most studies need to be duplicated a couple of times to form an established truth, each of these substances work in different ways to affect nf kappa b perhaps taking all of these may give some benefit.

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