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what's the best time to take accutnae?

Dermatologist has prescribed accutane 50 mgs daily for daughter, not sure what's the best time for her to take it? I told her to take it with her evening meal. I also think it is a high dose, she weighs 52 kgs and this is her third course. She is also 31 yrs. But I guess, the dermatologist should know what she is doing, I do not want to question her and she does her best. Also what moisturisers should she use? In the past she has tolerated accutane very well, but I think, she was on a lower dose. Thanks

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