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nate28

Possible Breakthrough in Acne Research

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it says in that dailymail article that it will be available in about 5 years..........im mean come on, i know it has to be extensively tested but thats ridiculous. sooooooooo annoyed

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Ah Ditropan. Very interesting detective work.

Yet I can't say that patients I know who take Ditropan (oxybutynin) have appreciably improved acne or dermatitis than others. In fact, one lady had severe perioral dermatitis and others had significant facial and back lesions and comedones. Sebum alone isn't the end-all, be-all for acne, as we know. Other factors are going to be necessary for success including keratinization and perhaps even shedding/ease of shedding, and then of course the bacteria p. acnes itself.

How significant is sebum? Who knows? But what else does accutane really address? because it seems to do the job for me.

I thought this was brought up in an old thread, but was optimistically thinking this was a new treatment. Has anybody dared experiment with what the drug seems to be. I wonder if I could talk my derm into trying it.

there has to be something to this ditropan stuff, otherwise they wouldnt have filed the patent with wipo. add to that they are a multi-million dollar company going out of their way to not release the name and also trying to create media attention with each passing trial..... im no medical expert myself however.....i dont think your doctor would give you a perscription for this stuff based on a patent application. well unless you had the other illness this medication was initally suppose to treat.

i never think its a good idea to self medicate, my acne is not bad enough for me to do such a thing.....but just out of curiosity, does anyone know where you can buy this stuff online, and i dont mean from some shady place. but i guess Internet pharmacies are a shaddy business aside from the legitimate ones that want a script.

5 years, god, that sounds long....but i mean they are trying to make a topical "potion" with this stuff and some other things. so to get the right combo they are going to need some time, plus it may not even work as a topical as well as oral. like i said before the oral version already exists, getting it is the challenge. although people seem to be able to get accutane, which seems like a more serious drug.

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I guarantee you it's not levodopa. Such a powerful drug would never EVER be approved just for the control of sebum! :)

l-dopa occurs naturally and you can get it without a prescription, made from Mucuna Pruriens

L-dopa is an amino acid that occurs naturally in usually trace amounts in some natural food sources (Mucuna Pruriens is unusually rich in it), but you still can't obtain PURE l-dopa without a doctor's prescription. But even the FDA and Congress don't have the balls to outlaw the importation and use of natural foods that are rich in it! ;)

.

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Yet I can't say that patients I know who take Ditropan (oxybutynin) have appreciably improved acne or dermatitis than others. In fact, one lady had severe perioral dermatitis and others had significant facial and back lesions and comedones. Sebum alone isn't the end-all, be-all for acne, as we know. Other factors are going to be necessary for success including keratinization and perhaps even shedding/ease of shedding, and then of course the bacteria p. acnes itself.

Agreed. I think if people are expecting oxybutynin to be as effective as Accutane just because of the rather similar levels of sebum suppression, they're going to be disappointed.

On the other hand, there _may_ be a serendipitous benefit to all this: if people start using oxybutynin and do indeed have levels of sebum suppression that are equivalent to what you get with Accutane (about 90% or so) without any other relevant side effects, it could finally, once and for all, lay to rest these popular notions that sebum is REQUIRED for human skin, that it helps "moisturize" the skin, that your skin will become cracked and dry and bleeding without sebum, etc. etc. If oxybutynin does nothing else besides squash those Old Wives' Tales, it will have served a very useful purpose! :dance:

.

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Reading the entry for oxybutynin in an old 1993 copy of the PDR (Physician's Desk Reference), I see nothing at all in the Contraindications, Warnings, Precautions, or Adverse Reactions sections about dry skin while using this drug. There is an entry under "Dermatologic" in the Adverse Reactions section, but it only says "Decreased sweating, rash."

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it says in that dailymail article that it will be available in about 5 years..........im mean come on, i know it has to be extensively tested but thats ridiculous. sooooooooo annoyed

with the amount of money that can be made, i would not be surprised if they found a way to cut it down to two years.

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Reading the entry for oxybutynin in an old 1993 copy of the PDR (Physician's Desk Reference), I see nothing at all in the Contraindications, Warnings, Precautions, or Adverse Reactions sections about dry skin while using this drug. There is an entry under "Dermatologic" in the Adverse Reactions section, but it only says "Decreased sweating, rash."

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yah that is very interesting but its also very strange. do you think dosage has anything to do with it?

I know some people who dont have acne but oily skin dont really pay attention to it much. But i mean if this stuff is suppose to be the holy grail than you'd figure one person who was taking it in the past for what its originally for would experience their acne disappearing. that is what happened with accutane, it was originally being tested for cancer and people that had cancer and acne had their acne disappear.

you'd figure something similar would have happened in the past with this stuff since i assume its been around a while. the only thing that comes to mind for me is that bladder problems usually effect mostly the elderly and children, where acne occurs a lot less.

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Argh, can't they just put it on the market already?

We have toys contaminated with lead paint all over the place, but an acne cure can't be sold for another 5 years?

My pimples are caused by oily skin, this is 100% certain, I get none where my skin is dry.

Release the product!

>:(

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Hello all; I found this on a hairloss forum, I thought I'd post it on here since its relevant. An article saying a new treatmeant that might 'cure' acne:

Link

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THese people of the pharmaceutical industry dont give a damn if we have acne the only thing they care is how to make the maximum profit from our illness.

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Hmm there was another post around about this as well. Apparently a drug that is already available for another disease/problem works better than accutane but they are still researching it to probably commercialise it before they release it in the market as a treatment for acne.

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ahh damn you cant be serious.

All those years of severe acne that caused scarring to me...

And at the moment I start to get clear, they come up with THE cure.

I'm so damn unlucky

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I sent the pharma company working on this drug an email seeing if I could get into the clinical trials and here is what I got back.

"Thanks for your e-mail. We hope to be starting phase II clinical trials in patients during 2009 subject to further successful phase I work in 2008. We don’t know yet exactly when or where the phase II will be run, but I will keep your e-mail on file and contact you again when I have more information.

If everything goes according to plan, the product will be completing clinical trials by late 2011 so should be available on prescription in late 2012."

Regards

Nigel

Dr Nigel Blackburn PhD

Director of Development

Summit ( Cambridge ) Ltd

So I guess that it really is going to be 5 years till it is available to the public. Hopefully they email me when the go into clinical trials.

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the 2012 is for the topical. topicals dont shrink oil glands. they may tempoaroly dissolve surface oils, like topical vit a and salicylic acid.

s the oral drung is already out there. males could use the drug to reduce sebum production , like how women use birth control to do the same.

and you would continue using your topicals to exfolaite dead skin to keep pores clear.

i dont expect the oral to reduce 90% and, i wouldnt want that anyway .if it could do 25-50%, that would be perfect.

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If this thing does have the same efficacy as accutane then i think it will become known before it is officially launched.

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Actually, topical makes sense. Because it could control the sebum flow only on the place you want the control - where you would apply the topical, rather than effecting the whole body, like a drug you take orally.

Please DO DO DO keep us posted, this sounds very exciting.

However, I am now seriously considering accutane. and it sounds like the release of drug won;t be for a while.

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Actually, topical makes sense. Because it could control the sebum flow only on the place you want the control - where you would apply the topical, rather than effecting the whole body, like a drug you take orally.

Please DO DO DO keep us posted, this sounds very exciting.

However, I am now seriously considering accutane. and it sounds like the release of drug won;t be for a while.

True, but I don't think a topical would be that great for people with body acne. Hopefully they'll do the same thing as tane and have a systemic and topical version.

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Moving to acne research forum and merging onto existing thread about the same drug.

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i dont topical will do anything to reduce sebum production, by shrinking oil glands. it will probaby only due what salicylic aicd and retin-a do which is dissolve surface oils.

i would want to take a low dose that would reduce oil 25-50% , so not to get too dry and continue with aha's. will see going to get prescription its cheap they said it works within days

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i would want to take a low dose that would reduce oil 25-50% , so not to get too dry and continue with aha's.

I'm genuinely curious as to why you wouldn't want to get "too dry" (whatever that means). Why would you NOT want to completely eliminate the steady appearance of a dirty, greasy oil on your face and scalp which forces you to wash regularly, not to mention tracks onto your clothing if you're not careful? It seems to me that COMPLETELY eliminating sebum (if one could actually do it) would be a win-win situation for everybody. To me, worrying about getting "too dry" makes about as much sense as worrying about getting "too clean".

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