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AutonomousOne1980

differin .3% will be out in july

Thank you for your interest in Differin® (adapalene) Gel, 0.3%. In response to your e-mail dated June 25, 2007:

“I was wondering when the 0.3 % formulation will be released on the market?

Thanks You.â€

This product should be available through prescription by July 2007.

Best regards,

Special Services Specialist

Galderma Laboratories, L.P.

Please do not reply to this e-mail. For further information about Differin® (adapalene) Gel, 0.1%, contact us at [email protected]

***The information accompanying this transmission is intended for the use of the recipient named above only. The information may contain confidential information, which may be legally privileged, confidential and exempt from disclosure under applicable law. If the reader of this message is not the intended recipient or the employee or agent responsible for delivering the message to the recipient, you are hereby notified that any dissemination, distribution or copying of this communication is strictly prohibited. If you have received this communication in error, please notify us immediately by telephone at 1-866-735-4137, and return the original message to us at the address below via the U.S. Postal Service. Thank you.

Galderma Laboratories, L.P.

14501 North Freeway

Fort Worth, TX 76177

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yeah :) i was follwing the phase trials online, and iv known about the 0.3% for sometime.

According to reports/documentation, Differin 0.3% is 60% more effective in 86% of patients :) and 100% equal effectiveness as 0.1% in the other 14%.

No reports of it being less effective :)

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1: Cutis. 2005 Aug;76(2):145-51.Links

The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris: A randomized, multicenter, investigator-blinded, controlled comparison study versus adapalene gel 0.1% and vehicle.Pariser DM, Thiboutot DM, Clark SD, Jones TM, Liu Y, Graeber M; Adapalene Study Group.

Virginia Clinical Research, Inc, Norfolk, USA.

A randomized, multicenter, investigator-blinded, active- and vehicle-controlled study was conducted to evaluate the efficacy and safety of adapalene gel 0.3% versus adapalene gel 0.1% and the corresponding gel vehicle. Subjects were assigned randomly to receive either adapalene gel 0.3%, adapalene gel 0.1%, or vehicle once daily for 12 weeks. A total of 214 subjects with moderate to moderately severe acne vulgaris were enrolled, and 85% of subjects completed the study. Adapalene gel 0.3% was significantly superior to adapalene gel 0.1% in total and noninflammatory lesion counts and in global severity score (P < .05 for all). A concentration-dependent increase in clinical benefit for all efficacy assessments was observed. As expected, there were also statistically significant differences in all efficacy parameters in the adapalene gel 0.3% group relative to the vehicle group (P < .001 for all). Treatment-related adverse events were mostly mild-to-moderate and similar between active groups. The results of this study show that adapalene gel 0.3% was superior to adapalene gel 0.1% and vehicle in the treatment of moderate to moderately severe acne while retaining a similar safety and tolerability profile to adapalene 0.1% gel.

the reason why im interested in differin 0.3% is because it is the least irritating of the retinoids, so by creating a stronger formulation theoretically you could get very good results perhaps equal to tazorac, but with much less irritation therefore making it the best retinoid topical available. but youll never really know until you actually try it for your skin.

the only problem with these studies is that they dont provide any exact numbers for the decrease acne. But when my acne was fairly mild differin worked extremly well for me, i have no idea how it would work now though.

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yeah, tootle :)

thats exactly why i requested differin, since i heard that tazorac causes red face/pain/irriation i was put off. And also Retin A can be like that aswell, but not as much as taz.

i cant wait for the differin 0.3% to get to the UK :)

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soon as you get Differin 0,3% please post your expirience

I think it will be great, differin 0,1% gel is the only thing that helped me (mostly closed comedones, blackheads, and sometimes whitehead/s)

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I asked my pharmacist and he knows its coming out soon, but hes recieve no pamflets/booklets ect on differin 0.3%.

But he said he has been to the conferance on new medications in london and hes seen galdermas slideshows and "before and after" pictures with differin 0.3%.

so i guess its gonna be great :)

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Hi there. My derm just prescribed Differin 0.3% for me on Friday. I don't know how well it works yet, but apparently my derm was excited about it. He said he's been waiting for it for 2 years. I'll keep you updated though.

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Damn, you got it already :S my pharmacists said hes recieved news that hes getting it soon :) but have to speak to my doctor about the actual prescription.

keep us posted :)

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I recently went to my first Derm appointment, well, ever. I'm 27 and for some dumb reason have just "dealt" with my bad skin since I was 10. (Retarded, I know) Luckily I now have an INCREDIBLY supportive boyfriend who pushed me to take action. (Like everyone, I complained a lot and still do) He consistently reminds me "WE are going to take care of it. No matter how much it costs, we won't stop until you're happy." :wub:

Anyway, long story short. My derm prescribed the Differin 0.3% gel, Mimyx cream, and Solodyn. he also recommended that I switch to using Cetaphil cleanser.

I picked up the Solodyn and Mimyx (40 bucks a piece!) and have been using them for about a week. I switched cleansers and have been using the Mimyx occasionaly. (it makes me feel really greasy if I use it everyday) Things are looking better, but it's hard to say what is helping if any of it since I just came out of my cycle.

As far as the Differin. I am still working with my insurance to get it covered. Without, I was told it would be around $150. Insurance is requireing a preapproval, and proof of "medical necessity" and blah blah blah. Anyway, be ready, you may have to battle the insurance demons to get it covered.

Oh, and it's probably a good idea to call ahead to the pharmacy. Mine had to order it. So, it is sitting quietly on the shelf waiting for me. :doubt:

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Luckily I now have an INCREDIBLY supportive boyfriend who pushed me to take action. (Like everyone, I complained a lot and still do) He consistently reminds me "WE are going to take care of it. No matter how much it costs, we won't stop until you're happy." :wub:

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Luckily I now have an INCREDIBLY supportive boyfriend who pushed me to take action. (Like everyone, I complained a lot and still do) He consistently reminds me "WE are going to take care of it. No matter how much it costs, we won't stop until you're happy." :wub:

You mean not all humans are money hungry, blood sucking follow the leader robot vultures????

HAHA!!! just kidding, thats great to hear that youve got some that REALLY cares about you.

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Well yes, in 80% of people who were on .1% who switched to .3%, they saw a 60% improvement in acne, while the other 20% saw no differance between the two strengths.

There was no decrease in effectivness, and no abnormal side effects (obv dry skin, initial oilyness, redness is common)

Though i saw that on "published articles" from galderma, though if its true or not, thats another question.

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