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Acne is not associated with abnormal plasma androgens

Plasma dehydroepiandrosterone sulphate, androstenedione, testosterone (T), dihydrotestosterone (DHT), and sex hormone binding globulin (SHBG) have been measured in 64 females and 26 males aged less than 25 years and with acne vulgaris. Oestradiol was measured in the males. Free T and free DHT were calculated. Acne was graded on three sites and the sebum excretion rate (SER) was measured in most patients. With the possible exception of free DHT, none of the plasma steroids or SHBG correlated with acne severity or with SER. Free DHT in the females showed a possible, but weak, correlation with total acne (r=0.25, P=0.07), but comparison with male data showed that this was not causative. The role of androgens in acne is permissive and plasma androgen measurements usually have no place in its management.

http://www.blackwell-synergy.com/doi/abs/1....1989.tb01351.x

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Plasma dehydroepiandrosterone sulphate, androstenedione, testosterone (T), dihydrotestosterone (DHT), and sex hormone binding globulin (SHBG) have been measured in 64 females and 26 males aged less than 25 years and with acne vulgaris. Oestradiol was measured in the males. Free T and free DHT were calculated. Acne was graded on three sites and the sebum excretion rate (SER) was measured in most patients. With the possible exception of free DHT, none of the plasma steroids or SHBG correlated with acne severity or with SER. Free DHT in the females showed a possible, but weak, correlation with total acne (r=0.25, P=0.07), but comparison with male data showed that this was not causative. The role of androgens in acne is permissive and plasma androgen measurements usually have no place in its management.

http://www.blackwell-synergy.com/doi/abs/1....1989.tb01351.x

yep!! its a confusing world trying to understand acne, there have been studys saying acne patients having skewed cholesterol profiles like higher triglycerides increasing with the more severe acne, lower hdl cholesterol, decreased risk of heart disease, deficient in apolipoprotein a1,and its more intriguing then any ancient androgen theory as sebaceous glands are undercontrol by many substances other then androgens. androgens are a very small piece of the puzzle, theres also 13 cis retinoic acid, vitamin d, ppar ligands even linoleic acid can potently stimulate sebaceous gland hypertrophy and lipid synthesis.

So they are definitly not strictly under androgen control by any means. Your brain will hurt if you try to understand it all, i hope you like pain!!!

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read this one, and think about whether or not your breakouts correlate with excess sugar consumption, you body may be in a state of insulin resistance and creating excess insulin and activating igf-1 production, causing sebaceous glands to grow and create more sebum.

something to consider at least.

http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum

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