lexomatic 0 Posted February 8, 2007 Ok, I have been using Differin for about 2 weeks now with success and am very happy with it. However, will the continued use of Differin begin to lose it's effect over time? Will I eventually have to move up to something stronger like maybe Retin A Micro or Retin A? I've heard of people who start off with a low more sensitve dose of Retin A and/or Retin A Micro and have to move up to a higher dose over time..... Inquiring minds want to know! Quote Share this post Link to post Share on other sites
Adam122234 0 Posted February 9, 2007 a Retin truly can't "Lose" it's effects...it's a routine thing used to clear pores and help with skin cells. The only thing you can become immune or resistant to is something that kills bacteria....they like to find ways around it after a while of being terminated... I've only heard of people going to a stronger Retin because one isn't working well for them... It would take years for you to potentially know that you're resistant to a Retin...if it's even possible. Quote Share this post Link to post Share on other sites
Madworld 2 Posted February 9, 2007 Actually, retinoids can lose its effect, in theory. The action of retinoids is due to it interacting with the receptors. Constant interactions can (in theory) lead to the de-sensitisation of the receptor tissues, causing the response to lessen. I'm not sure how this will apply in practise though. There's no evidence showing the retinoid effects diminishing over time. Quote Share this post Link to post Share on other sites
Komebackid510 0 Posted February 10, 2007 When I was on Differin, my derm. told me that it's highly unlikely that it could lose it's effectiveness over time. Quote Share this post Link to post Share on other sites
lexomatic 0 Posted February 11, 2007 Ahhhh MUCH thanks to everyone for their responses! I was jus curious. I don't want to have to change from Differin if it's going to consistently work for me over the years. Quote Share this post Link to post Share on other sites
callmeback 0 Posted February 11, 2007 Actually, retinoids can lose its effect, in theory. The action of retinoids is due to it interacting with the receptors. Constant interactions can (in theory) lead to the de-sensitisation of the receptor tissues, causing the response to lessen. I'm not sure how this will apply in practise though. There's no evidence showing the retinoid effects diminishing over time. Quote Share this post Link to post Share on other sites
Madworld 2 Posted February 11, 2007 1)use another retionid that targets other receptors and then go back to that retinoid if that does happen or 2)get a higher concentration of the chemical. Quote Share this post Link to post Share on other sites
callmeback 0 Posted February 12, 2007 1)use another retionid that targets other receptors and then go back to that retinoid if that does happen or 2)get a higher concentration of the chemical. You can't target other receptors with a different retinoid as they all deliver their anti-acne activities through the same type of receptors. Retin-A acts a MORE receptors (some which may be irrelevant to acne), therefore not well-tolerated. Newer designed retinoids like adapalene and tazorotene are more selective in this aspect and are generally less irritating. Receptor sites tend to break-down and replenish naturally, so there should be little worry about de-sensitisation... Quote Share this post Link to post Share on other sites
Madworld 2 Posted February 12, 2007 They both targets RAR-gamma and RAR-beta receptors, as far as I'm concerned. Quote Share this post Link to post Share on other sites
Turbojet 0 Posted February 13, 2007 For those who have used REtin-A....did your skin get worse before it got better? Quote Share this post Link to post Share on other sites
Adam122234 0 Posted February 14, 2007 Turbo....with ANY Retin...you'll get worse skin before better skin. But if you stick with it you'll thank yourself...it makes your skin look excellent. Differin, Ret A , Ret Micro, and Taz will all make you have a IB....typically anyways...there are ways to get around this....Oral Antibiotics and BP can majorly stop a IB from coming. Quote Share this post Link to post Share on other sites
Turbojet 0 Posted February 14, 2007 Turbo....with ANY Retin...you'll get worse skin before better skin. But if you stick with it you'll thank yourself...it makes your skin look excellent. Differin, Ret A , Ret Micro, and Taz will all make you have a IB....typically anyways...there are ways to get around this....Oral Antibiotics and BP can majorly stop a IB from coming. Quote Share this post Link to post Share on other sites
choccies 0 Posted February 17, 2007 this might be OT, but as a differin user, i was just wondering if it's ok to use AHA, then wait for 30 mins, and then apply differin? i'm considering this cos i heard it'd be more effective? would be great to hear your views! thanks! Quote Share this post Link to post Share on other sites
