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Twice a day if you are doing Dan's regimen. Here is a checklist that you can print out to help you remember the steps: http://www.acne.org/checklist.html

If the Nivea oil free moisturizer is non-comedogenic and nonmedicated, it should be fine, however many moisturizers aren't hydrating enough for use with the Regimen. You can try it out and see if it keeps your skin in balance, and if not you may want to try one of the recommended ones.

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