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Cause of oil - acne

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Sebum composition is as following:

Constituent - % by weight

Glycerides* and free fatty acids - 57.5

Wax esters - 26.0

Squalene - 12.0

Cholesteryl esters - 3.0

Cholesterol - 1.5

(* Include triglycerides)

P.Acnes "feeds" on the triglycerides (it secretes a lipase that hydrolizes sebum), converting the triglycerides into free fatty acid (ffa). Those ffa's irritate local cells (or are believed to contribute to the inflammatory process of acne).

I'd be interested in finding out, how the sebaceous gland actually works, how it gathers the glycerides/ffa's. Leung theory relates it to a pantothenic acid defiency that puts hormone synthesis before fat metabolism, causing the extra fats to accumulate in the glands.

Also, any people with biochemical background who could tell me if it is possible to break down the fatty acids inside the gland when it accumulates? Leungs topical B5 seems to provide pantothenic acid locally that might stimulate/ease the breakdown of ffa's, but I am uncertain about this.

Any info or ideas greatly appreciated!



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