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goodlife

Has anyone actually had bad side effects from Accutane/roaccutane?

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I keep reading some people advising people not to go on tane becasue of the possible side effects, but is there anyone here that has actually had bad side effects?

I was on Roaccutane for 7 months at 40/60mg a day, the worse thing that happened to me was my lips cracked a bit, but was simply remideed with a lipbalm, and that was it nothing else at all, my skin wasnt all that dry, i was perfectly fine when exercising.

I had several blood tests which showed no variation in anything in my blood, which of course if there had been i would have simply stopped taking it.

Roaccutane was one of the best things i ever did.

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Read below. Although, my case may be one of comorbidity or intervening cause in regards to the neuropsychological disorders. However, I can't find out because no doctor is willing to write me referrals for specialists and testing. I have to trick them into reading the studies so they have to send me. :lol::lol::lol:

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-Roaccutane Science: http://max001.proboards42.com

-Retinoid signaling, etc.

-FDA Advisory Committee on Accutane (2000)

-Accutane package label (2005)

-Package label history

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I used it about 10 years ago, but yes I did have bad side effects. Very high cholesterol readings that got higher and then dangerously high as treatment went along. But the worst was extremely dry skin. I mean so dry that when I opened my mouth to eat or speak, my skin would crack and start to bleed. People thought I had a strange disease. (And yes, I was applying a moisturizer at least 3 times a day) Also, accutane did not help my acne at all. Probably the worst thing I ever did for my skin. :evil:

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Read below. Although, my case may be one of comorbidity or intervening cause in regards to the neuropsychological disorders. However, I can't find out because no doctor is willing to write me referrals for specialists and testing. I have to trick them into reading the studies so they have to send me. :lol: :lol: :lol:

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uumm...not to be mean or anything...but how do you know all that was caused by accutane? it just seems like you are blaming all your problems on the drug. how do you know your problems weren't caused by something else?

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Some people do experience bad side effects on Accutane. Thankfully they are in the minority. I haven't so far.

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Bad depression? Cmon, depression really starts with yourself, and then accelerates with a drug. Accutane gave me really bad dry skin.

I never got depression cuz i went out of my way to do fun things and i exercised like crazy.

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Read below. Although, my case may be one of comorbidity or intervening cause in regards to the neuropsychological disorders. However, I can't find out because no doctor is willing to write me referrals for specialists and testing. I have to trick them into reading the studies so they have to send me. :lol: :lol: :lol:

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'nocturnal erections' :lol: :lol: everyone gets erections while they sleep man, maybe your so horny that they get painful, of your foreskin is to small, so when you get a boner it stretches beyond it's capacity.. or maybe just masturbate

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btw, for me... dry nose, dry skin, dry lips, sore back when i bend over and get back up. that's it, it is minimal and manageable.

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Wow i feel bad for some of you guys, I must have been the most sussessful case of tane ever then, not a single side effect and cleared my acne right up, anyone any ideas why?

Is it becasue im a super human being :lol:

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Most people only get the common minor side efects, but some unlucky souls do get the rare serious ones. It's a gamble, the odds are stacked heavily in your favor, but somebody has to lose.

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uumm...not to be mean or anything...but how do you know all that was caused by accutane? it just seems like you are blaming all your problems on the drug. how do you know your problems weren't caused by something else?

A substantial amount of scientific studies have been done on the drug which allow me to make reasonable inferences regarding its relation to particular adverse reactions.

Here is a post I made on the AccutaneAction.com board regarding the question:

Using your logic, here is another pragmatic fallacy.

We took accutane then we got severe health problems.

This means accutane caused our health problems.

Did accutane cause your side effects?

Response: Well, that's what I'm trying to find out. That is why I spend large portions of my time researching retinoid signaling, coercing my doctors to do the tests I request, and checking the Entrez database for experimental studies that substantiate my speculations with empirical evidence arrived at through methodologies that ensure the observations are falsifiable, and that causal relationships are highly probable.

Then there is the fact that no doctor is willing to perform the testing I request; they stonewall me. If they don't test for something, then legally there is nothing, so the doctors or the medical system are not liable for wrong-doing. And this is very dissappointing to me because they refuse to pursue truth that could possibly influence the well-being of other people. Really, what reason is there for not sending me for the testing I request?

'nocturnal erections' everyone gets erections while they sleep man, maybe your so horny that they get painful, of your foreskin is to small, so when you get a boner it stretches beyond it's capacity.. or maybe just masturbate.

Painful nocturnal erections are a sign of malfunction in neurotransmission and vasodilation. As for my symptom being caused by small foreskin, well, I am circumcised.

Penile erection is a very complex phenomenon and is an indicator of other health conditions of the body because of the many systems involved. Here is a nice review study on penile pharmacology: http://pharmrev.aspetjournals.org/cgi/content/full/53/3/417

Most people only get the common minor side efects, but some unlucky souls do get the rare serious ones. It's a gamble, the odds are stacked heavily in your favor, but somebody has to lose.

No long-term studies have been done on Accutane's safety. It cannot be conclusively said that the occurence of severe adverse reactions are rare because we do not know the incidence rates. All we have is Roche's trial data, along with meta-analyses for particular conditions, some whose methodologies have been criticised. Pharmacological dosing of vitamin A analogs may potentially lead to a myriad of long-term adverse effects.

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-Roaccutane Science: http://max001.proboards42.com

-Retinoid signaling, etc.

-FDA Advisory Committee on Accutane (2000)

-Accutane package label (2005)

-Package label history

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My best friend's roommate had horrible acne and took accutane in high school. It apparently gave him some sort of stomach problem (ulcer or something) for which he needed to take massive amounts of steroids. The steroids inadvertantly gave him worse acne, so he ended up worse than before. He also still needs to give himself enemas and whatnot sometimes when it acts up again. Eesh.

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No, no problems thus far! Dry lips, pores are cleaning out, a little achy, but nothing much to report. Oh, I did have some tummy aches from it in the beginning, but my tummy is sensitive.

K

PS-That whole nocturnal thing cracks me up :) Sometimes I wonder if DanK starts these threads just so that he can post about his side effects!

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Most of the things DanK blames on Tane are relative, and can only be measured by him. Cold intolerance? Well, a few years ago I'd go winter camping and see outside in a sleepingbag. Today, I'd freeze my nuts off if I did that. A few years ago I could run 5k, today 1k. A few years ago I could get by on only 6 hours sleep, today I'm useless without 8. A few years ago I still had a lush head of hair, today I'm thinning. A few years ago a finger cut would heal in a week, today it takes two.

DanK, sorry but its called getting old. You can attempt to blame everything on Tane, but you'll only end up with a biggest list at the end of the day.

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Ok...a more superficial side effect I guess but what about the severe breakouts many talk about as a side effect of the accutane. The flare ups or initial breakouts....are they basicly inevitable? I just started accutane 4 days ago (so far of course no affects) but I'm trying to prepare myself for the driness and the big breakout. Some seem to be saying that these breakouts seem worse than what they had before. How many is this true for? Is it most or a small portion?

Oh also....horrible question I suppose but if others are posting about erection issues LOL what about the driness for women. I mean does it effect vaginal moisture too?? Sorry :redface:

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Oh also....horrible question I suppose but if others are posting about erection issues LOL what about the driness for women. I mean does it effect vaginal moisture too??

Well, you have sebaceous glands there; it's definitely possible.

##

-Roaccutane Science: http://max001.proboards42.com

-Retinoid signaling, etc.

-FDA Advisory Committee on Accutane (2000)

-Accutane package label (2005)

-Package label history

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DanK, sorry but its called getting old. You can attempt to blame everything on Tane, but you'll only end up with a biggest list at the end of the day.

I'm 21 years old, not 80. If I go outside for more than 10 minutes in fairly cool temperatures, I start to become light-headed and loose the ability to open and close my hands. Cold intolerance is a symptom associated with possible decreased levels of insulin, vasodiolators such as nitric oxide, and androgens which occurs naturally as we age.

What knowledge do you have that qualifies you to decide whether my symptoms are or aren't related to the Accutane treatment I underwent?

##

-Roaccutane Science: http://max001.proboards42.com

-Retinoid signaling, etc.

-FDA Advisory Committee on Accutane (2000)

-Accutane package label (2005)

-Package label history

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Well Dan, it really goes both ways. One individual's anecdotal tale is not enough to demonstrate causality, and as you've harped on previously - there aren't long term studies that could quantify the occurance of particular effects - especially the bizarre effects that you mention. The truth is that those symptoms may indeed have been caused by Accutane, but on the other hand they may be coincidental or even a placebo effect - and given your long list of complaints it's possible that there's a little of each. Of course from your own perspective it's very cut and dry, but from an outside view it's all much less clear.

Cold sensitivity is also related to bodyfat percentage. People with more insulation tend to not feel the cold as acutely as those with less. People tend to lose weight during Accutane courses.

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