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Green_Vegetable_Man

I WANT PILLS OF P.ACNES

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According to Dr Anne Eady, (Skin research center, University of Leeds), “people suffering from acne had shown to be more resistant to certain types of skin cancer.�

According to Dr Eady, when P. acnes bacterium triggers an immune response, it enhances immunity to unrelated antigens including bacterial, viral, parasitic and tumor cells.�

Dr. Eady envisions a future where people will pop pills of P acnes in a bid to safeguard against more deadly disease than acne.

“Acne may simply be the price we pay for the optimum performance of a natural defense mechanism.�

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OK, your last post...GOOD!

This post.....well did you know that people that suffer from chronic acne, due to some hormonal/metabolic disorder are at MORE of a risk for cancer???

Not to mention, too much of any microorganism in our bodies is NOT a good thing.

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Guest Grow_To_Overthrow

I don't want to live for 150 years, cancer free, if it means a face full of nodules. :evil:

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TLR9 and bacterial immunomodulation

The intracellular parasite, Propionibacterium acnes, is used clinically to inhibit tumor growth and increase resistance to infectious diseases. Although immunostimulation is mediated by bacterial components, the host receptors have not been identified. Kalis et al. (p. 4295 ) found that mice lacking the intracellular receptor TLR9 did not exhibit the splenomegaly seen in wild-type mice 7 days after treatment with killed P. acnes. Wild-type mice treated with P. acnes had a 100-fold increase in serum TNF- and a 1000-fold increase in serum IFN- at 1 h and 4 h, respectively, after i.v. challenge with LPS, other bacteria, or their components; no elevation in the cytokine levels was seen in similarly treated TLR9–/– animals. Priming with three other pathogenic agents induced strong LPS hypersensitivity in both wild-type and TLR9–/– mice. Whereas wild-type mice had increased splenic expression of IFN- mRNA at day 7 following P. acnes priming compared with treated TLR9-deficient mice, both mouse strains had enhanced TNF- mRNA expression within 1 h of injection with bacteria. All P. acnes-primed wild-type mice survived a challenge with live Salmonella enterica serovar typhimurium, but all challenged P. acnes-treated TLR9–/– mice were terminally ill by day 6. The authors conclude that IFN-, released after P. acnes interacts with TLR9, is responsible for the bacterial-induced immunomodulatory effects.

http://www.jimmunol.org/cgi/content/full/174/7/3837

The bacteria that cause acne may protect sufferers from other infections and cancer in later life.

Scientists believe that the presence of the bugs, known as propionibacteria (P. acnes), may help to crank up the immune system so that is more effective at tackling subsequent infections.

It appears that P. acnes stimulates activity among a type of white blood cell called a Th-1lymphocyte which plays a central response in fighting infection.

Acne may simply be the price we pay for a natural defence mechanism

Dr Ann Eady

These cells specialise in fighting bacteria and viruses. However, they can also be mobilised to attack some types of tumour cell.

Dr Anne Eady, of the Skin Research Centre at the University of Leeds, said there was evidence that certain skin cancers are less common in people who once had acne.

She told BBC News Online: "P. acnes is what we call an adjuvant - when it triggers an immune response it does so non-specifically so that it enhances immunity to unrelated antigens (proteins that act on white blood cells) including bacterial, viral, parastic and tumour cells."

Puberty

It has been shown that acne can develop well before any other signs of puberty - sometimes in children as young as six.

Dr Eady's team are hoping to develop a test to predict which children are at risk so that they can be treated early to reduce the severity of the disease.

However, she admits that her work, while helping some to avoid the misery of a disfiguring condition, may actually be counter productive in other ways.

Dr Eady said: "Acne may simply be the price we pay for the optimum performance of a natural defence mechanism.

"If acne is eliminated we may begin to pay a much higher price as the incidence of certain cancers starts to rise.

"One day we may all be popping pills of P. acnes in a bid to stay healthy."

Acne is a disease of the tiny hair follicles found on the skin.

Each follicle is surrounded by glands that produce a protective oily substance known as sebum.

People with acne produce excessive amounts of sebum, which clogs up the follicle, and provides and ideal breeding ground for P. acnes.

Chemicals produced by the bacteria cause inflammation in the follicle and surrounding skin which results in the spots typical of acne.

The research is published in the magazine Microbiology Today.

http://news.bbc.co.uk/1/hi/health/1630307.stm

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Propionibacterium acnes associated with inflammation in radical prostatectomy specimens: a possible

link to cancer evolution?

Cohen RJ, Shannon BA, McNeal JE, Shannon T, Garrett KL

Uropath Pty Ltd, Perth, Western Australia

J Urol. 2005; 173: 1969-74

Purpose: Inflammation is commonly observed in the prostate gland and has been implicated in the

development of prostate cancer. The etiology of prostatic inflammation is unknown. However, the involvement

of a carcinogenic infectious agent has been suggested.

Materials and Methods: Prostatic tissue from 34 consecutive patients with prostate cancer was cultured

to detect the presence of bacterial agents. Prostatic inflammation was assessed by histological examination of

wholemount tissue sections.

Results: The predominant microorganism detected was Propionibacterium acnes, found in 35% of

prostate samples. A significantly higher degree of prostatic inflammation was observed in cases culture positive

for P. acnes (p = 0.007). P. acnes was separated into 3 groups based on cell surface properties, phenotype and

genetic grouping. All skin control isolates were classified as group 1 whereas most prostatic isolates were

classified as groups 2 and 3.

Conclusions: P. acnes has been isolated from prostatic tissues in men who underwent radical prostatectomy

for localized cancer and has been shown to be positively associated with prostatic inflammation. This

inflammation may then be linked to the evolution of carcinoma. Furthermore, organisms infecting these patients

with prostate cancer differ genetically and phenotypically from the commonly identified cutaneous P.

acnes isolates, suggesting that specific subtypes may be involved in development of prostatic inflammation.

http://www.scielo.br/pdf/ibju/v31n5/v31n5a17.pdf

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Guest Grow_To_Overthrow

With topicals we're only attacking the p.acne's on our faces!

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Guest Grow_To_Overthrow

With topicals we're only attacking the p.acne's on our faces!

O NOES!?!

I'm assuming this is one of your idiotic contributions. The condescending type that ironically provide no actual information.

I was making my comment in response to the original poster's thesis. He's talking of P.Acne bacteria preventing cancer in several places, the prostate in particular. I was merely stating that topical acne medications which kill P.Acne's on the skin will not actually effect the internal bacteria that prevents the cancers forming!

O NOES!?!, O HOW ABOUT YOU SHAVE YOUR BEARD TROLL!

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With topicals we're only attacking the p.acne's on our faces!

O NOES!?!

I'm assuming this is one of your idiotic contributions. The condescending type that ironically provide no actual information.

I was making my comment in response to the original poster's thesis. He's talking of P.Acne bacteria preventing cancer in several places, the prostate in particular. I was merely stating that topical acne medications which kill P.Acne's on the skin will not actually effect the internal bacteria that prevents the cancers forming!

O NOES!?!, O HOW ABOUT YOU SHAVE YOUR BEARD TROLL!

Unless I'm reading it wrong, it says that P. acnes IS associated with causing/contributing to prostate cancer because it can cause inflammation.

Conclusions: P. acnes has been isolated from prostatic tissuesin men who underwent radical prostatectomy

for localized cancer and has been shown to be positively associated with prostatic inflammation. This

inflammation may then be linked to the evolution of carcinoma. Furthermore, organisms infecting these patients

with prostate cancer differ genetically and phenotypically from the commonly identified cutaneous P.

acnes isolates, suggesting that specific subtypes may be involved in development of prostatic inflammation.

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With topicals we're only attacking the p.acne's on our faces!

O NOES!?!

I'm assuming this is one of your idiotic contributions. The condescending type that ironically provide no actual information.

I was making my comment in response to the original poster's thesis. He's talking of P.Acne bacteria preventing cancer in several places, the prostate in particular. I was merely stating that topical acne medications which kill P.Acne's on the skin will not actually effect the internal bacteria that prevents the cancers forming!

O NOES!?!, O HOW ABOUT YOU SHAVE YOUR BEARD TROLL!

relax for a second it was a harmless jab, really is it necessary to get riled up over "o noes?" come on man...waaaay too sensitive.

I think you're missing the point of this thread. Acne is regarded to boost immunity in the body against other antigens by boost t lymp production, therefore it's a good thing and that's probably why we evolved to have acne. Whether or not it's visible on the skin is probably just a genetic thing that has to do with individual skin types creating a place for acne to breed. However, with the prostate issue, you got that wrong; p acnes stimulates the growth of the prostate so that's not good. There is no significance in the fact that we only kill p acnes on the skin surface really. it's localized it's not an issue, killing the acne is just a consequence of other factors causing us to do it.

what beard?

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