I have now been on Curology for over a month. It doesn't seem to irritate my skin. My face is actually worse right now because I'm going to be starting my TOM next week. I'm going to try the Curology awhile longer I think. My Curology dermatologist told me to incorporate zinc soap by Nobles into my regimen. I started that yesterday because it has 2% zinc pyrithione in it which kills fungus and bacteria. I always get HUGE zits a week or two before my TOM(time of the month) so today I had my primary care doc put me on Spironolactone. She said I shouldn't do Spironolactone she birth control. She wanted me to do one then maybe add another. She put me on 50mg 2x day, but she didn't give me any refills? I guess I'll have to call her to get a refill when needed? Has anyone else tried Spironolactone out there?