Over the past four days my skin has become used to the medication. I no longer have to moisturize multiple times a day for dry skin, although my face is still pretty flaky and tight at times. I have continued to see an increase in pimples, but not at the same rate as before. I have also had a few whiteheads on and between my eyebrows as well as on my lips. The doctor said that my skin would get worse over the first 2 weeks and it looks like she was right.