For the first 2 days of using Differin I saw absolutely no changes in my skin. Then, on day 3, the area around my mouth began to flake horribly. On day 4, my eyes dried up and started flaking. On days 6 and 7 I started to break out on both cheeks, my chin, and my forehead. Mostly non-inflamed whiteheads, although there are a few red pustules on my cheeks and forehead. I hope this is the initial breakout that is associated with Differin. I'm not sure if it's normal to have the IB this early though.