Two weeks ago I moved down from taking one Bactrim pill a day to one only every other day. My acne hasn't flared up at all. I still get whiteheads and pimples, but they're definitely not as bad as they used to be. Still using Epiduo in the evening. Don't know if I've seen much improvement with my hyperpigmentation. I had a derm's appointment scheduled for Monday, but I've a project to work on so I'm going to reschedule it for probably next week. By then I'll already have been off of Bactrim for a week, so let's hope things don't take a turn for the worse :s Really hoping to start working on getting rid of my scarring!