So I have been clear for a long time on retin a .04, oracea, ortho cyclen, and duac. I stopped taking oracea for two weeks, and my skin went crazy. I promptly returned to taking it, but I am at week 5 and my skin is bad. I have decided to switch to solodyn and retin a 1%. I have a dermo appt in 3 weeks so I will see what happens until then. My skin is irritated because I put gobs of duac and retina a micro .04 on them. I am going to use pea sized amounts of 1% and duac from now on. I will keep you updated.