now that my period is over, i haven't had a whitehead around my mouth in a week! part of it i'm sure is hormonal, but i've also started (actually following the instructions on my bottle of spiro) taking each pill with a glass of water. i'm wondering if maybe the water helps the medicine be better absorbed into your system? also, this is the end of week 11! of using retin-a .1 on my forehead. it definitely looks better--smoother overall. there's still a few clogged pores that i can see. i'm hoping that after 12 weeks it just keeps getting better.