I am on my 4-5th week of Spironolactone. Its stil hard for me to tell if its working but so far I have only had one pimple which I guess is amazing...but I want more. I want zero pimples forever! Maybe thats just a dream...I am on a 50mg a day dose of spironolactone. I also take 1,000mg a day of amoxicillin and tonight I switch for awhile to cephalexin at the same dose. On top of that is tretinoin and topical clindamycin. My skin is pretty clear but the moment I let up on any one of my creams, I get tiny breakouts. I want to be on the maximum dose of absolutely every drug available to me. I ran out of topical clindamycin so I am temporarily using benzaclin, a combination of 2.5% Benzoyl Peroxide and 1% Clindamycin. Its kinda weird cause it keeps in the fridge.