Today, I am on my 4th day of accutane... The first couple of days, I didn't notice any effects. No dryness or anything. But yesterday I did notice that my face was drying out considerably. And I am only on 20mg per day! Now, on the fourth day, the skin on my face is flaky and I have really dry lips.. I will have to discontinue the use of any cleansers for now.. it looks like it's going to be a long, miserable road to clear skin.. But hopefully it will be worth it!