The first few days on Accutane I had no appetite at all. I'm a pretty small person to begin with so not eating is definitely a concern! I made myself eat small meals frequently throughout the day and by the fourth day my appetite was back to normal.
There were no negative side effects the first week of treatment.
The only thing I did notice was that I had no new breakouts! Very nice for a change. My skin was less oily and looked quite healthy (besides the scarring of course!!)
I have been very diligent about washing my face with the mild cleanser (Vivier HEXAM) recommended by my derm and moisturizing with his own brand of cream. It's a very light cream, quite pleasant feeling and seems to be keeping my skin hydrated but not oily.