I went to an outdoor party this weekend and got eaten alive by mosquitos. I noticed some of the pumps were more red and some of them had a clear-yellow blister in the middle. I heard it is generally best not to pop your skin as this prevents bacteria from gaining access to open areas of your skin and causing an infection. It's best to allow nature to take its course and let your skin heal naturally. I couldn't resists popping just one but now it itches like crazy. Why did my skin make the yellow puss/blister on the mosquito bite?