i set my alarm for ten am to take my very first dose of isotrentinoin. i have been so excited for the past few weeks that every time i saw a new blemish in the mirror i would laugh in my own face, telling myself it was one of the last i would have to deal with. i bought a little 2-a-day weekly pill organizer and took the liberty of emptying the first box the day before i planned to start it. i made sure to swallow my first pill with a tall glass of water and chase it with a granola bar, since i'm not one big on breakfast. so far i have seen no changes, as expected. my only current worry is how much worse it's going to get before i'm going to notice a difference.