Well, I started Accutane on Feb 28th. Today is March 12th. By the end of week one, I had a major flare up. A lot of cysts. My face hurts horribly. (Oh, btw, I'm 28, female, african american, lots of active pimples, and lots of blackheads and scaring) Along with the flare ups, I got the expected very dry lips and skin. Last night I had my first nose bleed. Luckily it happened in the shower After the nose bleed last night, I took a cotton swab, swished it in some vaseline and rubbed it in my nostrils. I'm not sure if it'll help , but I repeated it again this morning. Today is day 13. I will keep everyone posted. Oh, I'm on 60mg, and taking Yaz for birth control.