I am currently taking 100mgs-50mgs of spirolantone. I have been on it for almost 3 weeks. However, I am still taking about 30 mgs a week of acutane to keep zits away. I figure I will take these 2 together for about 2 months then quit the accutane and see if the spiro is working. If soo great i have finally found my cure. When I first started taking the spiro my skin broke out a little. Im guessing an IB but lasted only a week and the accutane dryed it right up. I wont know the effects of the spiro until I stop taking them together. Im very nervouse to stop the accutane bc it has been my saftey blanket for about a year. ...keep ya posted!