Aspirin breaks down into salicylic acid—a well-known ingredient in topical acne products—when dissolved in water. However, getting salicylic acid this way and applying it to the skin can be unsafe. Salicylic acid products are widely available and inexpensive, so simply buy one over-the-counter.
Baking soda may be slightly antibacterial, but it is also abrasive and can cause skin irritation, which could lead to breakouts. Also, it is alkaline, and the skin is acidic, which is not a good match. Therefore, baking soda is likely not a good idea for an at-home acne treatment.
Increased calories might increase skin oil production, and thus make acne worse. Is this why most "acne diets" tend to work in the short term when "bad" foods are eliminated and calories end up getting reduced? Perhaps.
The Acne.org Regimen is a 3-step treatment that will completely clear even stubborn cases of acne. It involves using a Cleanser, Treatment (2.5% benzoyl peroxide), and Moisturizer in specific ways and at particular doses.
Accutane (isotretinoin) is a powerful medication that is approved for people with severe acne that is non-responsive to other treatments. It is the most effective medication on the market for acne, but also comes with a worrying list of side effects, some of which can be lifelong.
Acne dysmorphia is a rare but debilitating mental illness, linked to body dysmorphic disorder, and similar in psychiatric terms to Anorexia Nervosa. People with acne dysmorphia feel obsessed with skin imperfections and often damage their skin through picking.