My teenage daughter has suffered for acne for the last 4 years. Long term trimethoprim-sulfamethoxazole therapy failed.
My daughter started to suffer from nodulocystic acne. With a severity such that touching her face caused pain from nodules (everywhere,cheeks, chin, nose crease, forehead, even eyebrows and eyelids).
Minocycline didn't help even after 1 month. We were considering accutane but concerned about IBS and Crohn's.
Saw clinical studies about Patothenic Acid (B5).
After 1 week at 4.5 grams daily (1.5g 3 times daily) improvement was evident. After the next week at 6g (2g 3 times daily) her face is remarkable. You would not believe it is the same girl.
It may not work for everyone -- but it has for her.
It is like a miracle.
To keep surface acne down and keep comedones from forming, and also for scar remediation she is using BP and mild dermabrasion.