This medication saved my self confidence and sanity. I had previously been on Ortho Tri Cyclen for 15 years and had perfect skin. October 2011 I severely fractured my ankle which led to a blood clot in my leg. Due to the clot, I can never take hormonal medications again. So, on top of not walking and worrying about the clot, my face and body decided to explode with acne. I had it all over my cheeks, chin, forehead, neck, chest, back, butt, you name it and it was there. Pretty traumatizing when I never had acne before. I have fair skin that scars very easily, so now as soon as the old zits would leave, i had hyperpigmentation spots on top of new zits. I tried every topical I could think of, and nothing worked. My normally outgoing personality faltered as I was horribly embarassed to be around people and show my face. I felt like I couldn't wear low cut shirts and I didn't want to even leave the house. I cried myself to sleep every night. I finally managed to get into my dermatologist in March 2012. I had read all these reviews about Spiro and prayed that the dr would prescribe it and it would help. He took one look at my face and started me on 50mg daily of Spiro. At first I didn't see any changes, then about three weeks down the line my face and chest got even worse (which I didn't think was possible) then started to clear some. My body acne and chest cleared up at that point. In July, my face broke back out into large cysts. Luckily I went back to the derm a few weeks later and he upped my dose to 100mg daily. My whole face cleared up immediately. It was even a little dry, where I was used to having an oil slick on my face. I still saw improvement the last few months. I get a couple tiny pimples here and there but whatever. I can gladly deal with them! My chest still had a few, and I added in zinc for skin healing and now those are gone. I couldn't be happier and I finally have my life and self confidence back. It's amazing. I hope this helps anyone who thinks