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Active Ingredients:
25 mg, 50 mg or 100 mg of Spironolactone.

Inactive Ingredients:
Calcium sulfate dihydrate, colloidal silicon dioxide, croscarmellose sodium, crospovidone, hypromellose, lactose monohydrate, magnesium stearate, peppermint flavor, polydextrose, polyethethylene glycol, povidone, pregelatinized (corn) starch, sodium lauryl sulfate, titanium dioxide and triacetin.

Items marked with orange can be irritating and over-drying, especially to acne-prone skin.

The list of ingredients above is provided for informational purposes only. Always check the actual product label in your possession for the most accurate ingredient information due to product changes or upgrades that may not yet be reflected on our web site.


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Reviewed on September 8, 2015

I honestly cannot recommend this medication highly enough!

A bit about me....

I'm 24 and have been suffering with terrible acne since finishing birth control 3 years ago (Yasmin). Never previously suffered with it. Acne was destroying my life....I hated going out in bright sunlight, I couldn't look people in the eye and dating was out of the question. I spent most of this summer in hibernation...not living at all.

I was contemplating going back on Yasmin as a last resort...I had tried being dairy free etc and nothing worked. Finally I saw Spironolactone mentioned on a forum but I was really hesitant to give it a go - Reading reviews like this are what encouraged me but I was skeptical. I bought it online because it is really difficult to get prescribed it in the UK. I wouldn't normally recommend doing so but as a medical student I was confident with the research I had done and my understanding of how it works - Generally it is pretty safe (especially in comparison to birth control).

So how long did it take to work? 7 days.

Dose - 100mg every morning.

I was prepared to wait it out but it honestly had an instant effect for me...I haven't been on it long but so far so good.

After one week my skin was clearer than it had been in 3 years. My skin felt completely different, my pores were terrible cystic acne was healing and all the little tiny bumps all over my forehead were disappearing.

I'm still waiting to see if I get a delayed initial outbreak...but I don't think I will. My skin improves every day. I feel like I have my life back again.

Side effects:

Dizziness and nausea for the first few days.

Frequent urination (Make sure you drink plenty of water)

Fatigue - I am a lot more tired most of the time!

However, the pros far outweigh the cons and the side effects have only been mild for me.

If you're contemplating Spironolactone....Do it! It could be the best decision you ever make.

by jacqueline420 on 09/21/2015 20:52
would you mind please sharing where online you were able to obtain it?
On the fence
Reviewed on September 4, 2015

I did 2 rounds of accutane and it kept acne away for maybe a year. But it slowly starting coming back. I had a bad cause of acne but it wasn't cystic. Now i had 2 huge cystic zits that he actually gave me cortisone shot in. Ouchy! The derm put me on 100mg of spiro and now my face looks Bad!! I may have jumped the gun but I had 2 huge cystic zits that scared me. I think if I would've just let them be I would've been ok but I started taking the spiro and now I look like crap. Tons of tiny red pimples all over cheeks. Is this purging? I also just generally feel like crap. Headache, light headed, body ache, groggy. I hope this med pans out for me.

Skin looks great but losing hair
Reviewed on September 2, 2015

I have been on spiro 100 mg for about six months now and have seen great results; however about three months ago I noticed my hair hair really begun thinning. A little bit of history about myself. I am 47 years old and have suffered from cystic acne since a teenager. I have done several courses of accutane, which cleared my skin greatly only to go back to breaking out again. My new derm said I would love Spiro since my breakouts were hormonal. She was right. It reduced my oiliness and cleared up my skin. My skin never looked so good. I got so many compliments. However, then I started noticing the hair loss. So I do have some family history of hair thinning in women and had noticed that my crown had thinned in the last seven years or so. However this new hair loss has been pretty drastic. My scalp is really showing on the top of my head, and I seem to be shedding lots of hair when shampooing and throughout the day. I'm going back in to see my derm tomorrow hoping she may have some answers. I share this info in case anyone else has experienced similar symptoms. I've read up on it and can't really find that hair loss is a symptom rather quite the opposite as it's used for hair loss?? So if you don't experience the hair loss with it, I think it's great and would recommend trying it.

by aj12345 on 09/02/2015 16:00
I have been on spiro for three months and have noticed a drastic change in hair loss. My hair was very full and has thinned out dramatically. Very happy with skin though so far! Going to ask about the hair loss at my next appt....
This medicine totally works- be patient!
Reviewed on September 2, 2015

I am a 33 yr old female. I've been on this drug for three months now. I am finally so much happier with my skin! It was so depressing and awful to deal with months ago. I thought the acne wouldn't stop. And using a ton of makeup was disheartening and exhausting to cover everything up.

Note: I've been battling acne since I have been a teenager. With that said, I have taken antibiotics, tried face washes, creams, cleansing wipes, vitamins, you name it- even Accutane when I was 28. My skin was super clear from the accutane and stayed this way for a number of years. In the last two years, my skin started acting up again and in the last few months the hormonal cystic acne became really bad. When the new dermatologist I was seeing recommended spiro, I was completely on board after nothing seemed to help. she also prescribed oracea to take along with the spiro. I felt like while I was both that my stomach was upset. Anyway doc said Oracea would help speed up the process she said with the healing. I started the spiro at 25 mg and after a couple weeks upped it to 50 mg. I honestly didn't see much result in the first Month. And I was taking the antibiotics as well. It just takes a while for the med to work. So towards the end of my second month I was happier but not completely. The doc At the end of month said to stop the antibiotic and upped my spiro to 75 mg per day. Since then my Month 3 has been great! My skin is smooth,the scars are healing every day and I haven't had a deep cystic pimple in weeks!! I have been keeping a photo journal and it's crazy to look back and now at my skin. I'm not sure how Long I will stay on but I am definitely pleased. Along with the spiro I have been using a prescrip face wash, wipes, and adapalenegel at night. Keeping your skin clear is definitely a commitment and is worth all the effort when you see the good results. Because I've battled with this my whole life, I know how it feels to have bad skin and it's the worst feeling! I would definitely recommend spiro and im glad there was something other than accutane to take. Couple cons are feeling like you have to go to bathroom- this was more in beginning. Also Drink a lot of water !! And the one big one is hairloss. My hair has thinned out drastically. I'm hoping once I do stop that it regrows! But I will keep taking this drug as long as possible. It really saved me- I was a mess. ! I wish anyone that take this good luck and just be patient!

This stuff is awesome, but it's not a quick fix!
Reviewed on August 27, 2015

I am a 23 year old female who has been suffering from acne since before puberty. My acne runs the gamut from blackheads to whiteheads to severe cysts. I went on an oral contraceptive when I was a teenager and that helped keep my skin clear for a few years, but about a year ago my cystic acne returned with a vengeance. I would say it was worse than it had ever been, and nothing topical was helping, so I went to my dermatologist. She explained that spironolactone is a good option for women who are out of the teen years, but are still dealing with considerable hormonal acne. She started me on a dose of 150mg of spiro a day, along with a course of doxycycline and a topical retinoid (Ziana). The important thing to remember about spiro is it takes a while to kick in, so please don't get discouraged if you don't see results right away. I continued to break out pretty bad for the first two months I was on it, even while taking the antibiotic. But then suddenly it was like the spiro had just been building up and finally started to kick in and work its magic. My breakouts slowed dramatically, and I discontinued the doxy. I take 100mg of spiro in the morning and 50mg in the evening (it is a diuretic, so it's better to take your higher dose earlier in the day to prevent waking up at night to pee), and am using the retinoid twice a week. My skin hasn't looked this good in a long time. My skin's oil production has slowed down too, which is a great bonus. I still struggle with some blackheads in my t-zone, but my cystic acne is 99% gone, and that's my main concern (I can treat my blackheads, but cysts have always been an uphill battle).

Side effects (THAT I NOTICED):

*The biggest one for me is dizziness. Spiro lowers your blood pressure, which isn't dangerous in itself, but it's just something to be aware of because it can cause you to feel light-headed. If I am dehydrated when I take it, I can get dizzy and am prone to really bad head rushes when I stand up. But if I make sure to take my spiro with water and some food, I don't really have that problem. I have found that if I get dizzy, eating something salty helps a lot.

*The first few months I had some issues with tiredness for a few hours after taking my doses, but it seems I have gotten over that now.

*I drink a ton of water and I am used to going pee more than the average woman, so the diuretic effect doesn't really bother me. But I imagine it might be annoying for some people.

I would recommend this to anyone, but just know that it's not a quick fix! It will most likely take some time to work for you. Be patient and you will see good results!

by ko12345 on 08/27/2015 16:51
I am just at my 2.5 month marker (1+ month on 50mg, and now most recently 1+ month on a dose of 100mg). At what month marker did you start dramatically clearing?
Thank God for this medication
Reviewed on August 21, 2015

A year ago I had cystic acne around my mouth and chin. As many know, cystic acne does not respond to topical treatment 9 out of 10 times. (I would actually say 10 out of 10). Initially i thought it was my diet, so I cut out all carbs, sugars, dairy, etc. hoping that it would change something. I juiced every day, drank nothing but water, and still nothing changed. It got to the worst it has ever been last July. My entire skin broke out in a way that was unimaginable and quite frankly unbearable. My self esteem was so low and I spent months depressed and avoiding social interaction. I ended up diagnosing myself with PCOS after hours of research. I figured out that acne resulting from PCOS is due to increased androgen (testosterone) production and insulin resistance. Basically, sugar and testosterone together can lead to the perfect environment for acne to thrive. I went to my derm and OBGYN and found that indeed my testosterone was high. and my derm wanted to put me on accutane; but after doing research myself I realized that accutane does not target hormonal acne. Therefore I thought Spiro would be best, and he agreed after I asked his opinion at my next appointment. I was on 50mg a day at first but after a week or so decided to bump it up to 100 myself. It has worked miracles for me and I havent really noticed an negative side effects at all. Ive been on it for almost a year and have no complaints. I am beyond grateful for it. I have found that taking supplemental ZInc 30mg a day as well helps (read more for yourself. works like an antibiotic). Also, mainting blood sugar is so important in order to make sure you dont experience spikes throughout the day. I eat a lot of high protein food and do not eat any breads, pasta or things containing flour. NO sodas, sweets, or dairy really. Mostly salads and lean meat. Ill have a cookie every now and then though ONLY after Ive eaten a high protein meal so that it isnt the first thing to hit my stomach. Hope this helps!

[link removed] <---- great info about acne and PCOS as well as other hormonal issues

by ko12345 on 08/22/2015 00:51
How long until you saw real results??
Spiro worked, but cutting out dairy was the acne cure for me
Reviewed on July 28, 2015

I never ever write reviews, but I felt the need to share my experience on spironolactone. In my early 20s, I went on spironolactone as a last resort. I had terrible hormonal acne for years along my jawline and red inflamed skin no matter what I tried. Spironolactone worked like a charm for me, and I was on it for almost 4 years with absolutely perfect skin. However, after some time, I started to develop digestive issues and generally did not feel well most of the time. At the recommendation of a doctor, I decided to go off of Spiro at that time. After a few months off of Spiro my acne came back full force, but I remained off of Spiro for another two years. During that time, I coincidentally had food allergy testing done and found out that I had a mild dairy allergy. I cut most dairy out of my diet (not all, but definitely cut way back on dairy) and after about 6 months my skin became perfectly clear again (just like when I had been on Spiro). I've been off of dairy for almost two years now and my skin is still clear. For me, I believe dairy had been causing a hormonal imbalance which Spiro had temporarily covered up years before. While I don't know this for sure, I wanted to share my story in case it happens to be the same for any of you. A natural cure may be possible depending on your situation. Good luck to all of you in searching for an acne solution!

by ko12345 on 08/03/2015 20:18
How long did it take for you to see results on spiro? Also what was your dosage?
Reviewed on July 22, 2015

Spiro literally dried my whole body out! Sure it helps the cystic acne, but at what cost? In 4 months, I gained wrinkles, weight, cellulite, dry eyes, acid reflux and my stomach is constantly bloated. I play soccer constantly and was starting to feel weak....BAM ....muscle loss. I was randomly sweating, I was literally red all the time. I already had sufficient breasts, now they are huge, painful, and annoying! I have been off of this evil drug for 2 weeks and feel a ton better, but still have the bloating, cellulite, and dry eyes. Also, I have issues with anxiety, and this stuff made it WORSE!!!! My skin has NOT gotten worse since I stopped taking it, it has gotten BETTER. How long until all the side effects go away!!?!?!?!?! Anyone else hate their Dr for putting them on this????? I only gave this 1 star because it made me. Should have negative stars!!!!

by 1976SJG on 07/23/2015 20:48
How many mg did the doc put you on??
by Meredithdemp on 08/12/2015 14:01
When did u notice cellulite
I am finally happy
Reviewed on July 22, 2015

Hey everyone,

I am 16 years old and I have been on spironolactone for exactly 3 weeks now to treat my hormonal acne.

I've had acne for 2 years now but just this past year it's gotten dramactically worse. I was trying everything! No matter how much I cleansed my face, used on the spot treatment, or moisturized my face, there was no improvemnt. In a matter of 4 months, I had 2 cystic pimples underneath my eye that caused it to swell almost completely shut and even slight bruising. I had to miss 2 days of school because of terrible, swollen zits(EMBARRASSING)! I then got put on antibiotics for 10 days which cleared my face up both times, but unfortunately I couldn't use the antibiotic as a long-term acne medication. I got put on birth control 7 months ago solely for acne. Once again, there was no improvement. Each day my self confidence was slowly decreasing. My mom finally took me to the dermatologist when I had one of my breakdowns in front of her. She asked what was wrong and I told her I hated myself. The truth is, I didn't hate myself, but I was so upset and embarrased about my acne. I just wanted a simple clear face like all of my friends and relatives. In the morning I would spend almost an hour doing my makeup to cover up my scars and pimples and even with concealer you could see some blemishes.

Now back to spiro... I am SO HAPPY about the results I've already had! This has been the first time in forever the my forehead has been completely clear. The blackheads on my nose are going away more and more everyday. The white heads on my chin have decreased in size. The big zits I had on my cheeks are gone! GONE. I feel like some of the scars on my face are beginning to fade as well. I have 2 small pimples that are tolerable and coverable with concealer. I was actually able to go in public yesterday without foundation and using only a small amount of concealer. I was beyond excited about actually feeling confident with my face with hardly any makeup. I am out of my "hating myself" state and I can't wait to see better results in the next couple of weeks.

For anyone looking into this medication whether you're a teenager or an adult, I highly recommend it!! This medicine has helped so much and it's only been 3 weeks. (For anyone wondering, I have been on 50mg the entire time)

by kojak on 07/29/2015 23:35
What dosage are you using?
Day 38 -- trying to be hopeful
Reviewed on July 21, 2015

Background- my doctors believe I have an atypical case of PCOS (meaning I don't have many of the symptoms most women with PCOS have, but do have polycystic ovaries), found this out in March 2015.

Day 38 of 50mg/day of Spiro & just started my third pack of Beyaz BC pills. So needless to say my skin has been going through a rollercoaster of hormonal changes the last 2 months & I have been so depressed about it. Since starting both meds, I have had at least 2 active cysts on my face at all times (and many other acne spots that are scaring or trying to heal). I feel like I have been living at the derm office with all the weekly injections I am getting (really is the only way for my cysts to diminish). Yesterday, my derm agreed to up my dosage to 100mg of spiro a day. I am PRAYING this is what will do the trick. I know that I need to give the spiro & BC pills time to work (they say 3-4 months?). But I am sure others can agree that acne is so draining, it's all I can think about and has literally spiraled me into being depressed. Any words of encouragement? Do I just need to stick it out for results? Thanks so much for any responses :)

by ko12345 on 07/22/2015 14:39
I should mention that I am 28 years old, and always had moderate acne until I did a round of Accutane 6 years ago. It kept me clear for literally 4+ years until I made the decision to go off BC pill, and slowly everything came back. Did anyone notice a great difference when they upped spiro dosage from 50 to 100mg?
by Stallion07 on 07/26/2015 18:41
I didn't see results until upping the dose to 100mg (50mg twice daily). Maybe 3 weeks in on 100mg after 2 whole months on (25mg twice daily) 50mg. I don't take any birth control as I believe it is the devil that fluctuated my hormal acne I didn't have cystic acne until I tried the pill although I'd been battling acne for years. The pill and plan b made a monster. But my skin is doing great at 100mg no breakouts overall appearance has greatly improved I swear in the end of week 3 I wokeup one day and my skin just looked great and has gotten better day by day scars fading small pores etc. Currently a total of 3 1/2 months on spiro
by ko12345 on 07/28/2015 16:59
Stallion07 -- thanks so much for the positive reinforcement!! I will update my progress in a couple of weeks to let you know how I am doing on 100mg a day!
by Stallion07 on 07/29/2015 16:14
ko12345 Great keep me posted and have faith it'll get better I promise.
by ko12345 on 07/29/2015 20:57
So you said it was about 3 weeks after you started 100mg that you noticed a difference? Or was it gradual over the 3 weeks?
by ko12345 on 08/25/2015 16:50
Wanted to update my last post bc I know how much I appreciate when other gals update their posts. My last post was at 38 days (so just over 1 month). Here I am at day 73, so almost 2.5 months on spiro all together. During this time, I have most recently been on 100mg for 1 month & 5 days. I have noticed that cystic flare ups have diminished somewhat but I am still breaking out with normal acne & have a lot of scarring from the initial IB. It definitely has been a rollercoaster these past 2.5 months and I am doing my best to hold on tight and stick it out. Still have not reached the results I hope for and I realize that I need to give it at least 4 months from what I have read. Side effects: tender breasts, lack of motivation to work out (and I used to work out religiously) and some muscle fatigue. But these side effects are quite mild and I am determined to give this medication my best go! Here is to hoping for clarity in month 3 :)
by ko12345 on 09/15/2015 20:17
MONTH 3 UPDATE: here I am at month 3 and I have not reached the results I had hoped for. The cystic type acne definitely subsided when I upped my dosage to 100mg but the other acne did not stop, then right on the day of 3 month mark I got a big cystic one that came up. I wonder If I just need more time on the drug? I have made decision to do Accutane to stop my mild yet VERY persistent acne. It's been a long time coming and I feel like I really gave spiro a fair shot.
by TaneBabe on 03/03/2016 02:31
Hi there! I just wanted to let you know you are not alone. I never considered Accutane until I tried Spiro for about 3 months. This drug made my skin take a turn for the worse; I believe it was just another factor fluctuating with my hormones which caused actual acne for the first time in my whole life. I am not starting 'Tane in 12 days and have been off Spiro for about a month- my skin is already SO much better. I also think Accutane is better than Spiro because for most people (75%; but especially people with mild acne like me), it is only a 5-month process that lasts a lifetime without having to worry about taking a pill for years and years like spiro. If anyone actually reads this, please do not try this drug unless you are for sure PCOS or older. Young girls like me may experience a complete overdose of female hormones, and trust me, it is not pretty....