Page 4 of Spironolactone reviews

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Active Ingredients:
25 mg, 50 mg or 100 mg of Spironolactone.

Inactive Ingredients:
Calcium sulfate dihydrate, colloidal silicon dioxide, croscarmellose sodium, crospovidone, hypromellose, lactose monohydrate, magnesium stearate, peppermint flavor, polydextrose, polyethethylene glycol, povidone, pregelatinized (corn) starch, sodium lauryl sulfate, titanium dioxide and triacetin.

Items marked with orange can be irritating and over-drying, especially to acne-prone skin.

The list of ingredients above is provided for informational purposes only. Always check the actual product label in your possession for the most accurate ingredient information due to product changes or upgrades that may not yet be reflected on our web site.


Where to buy is not associated with this product. All proceeds from links go to charity.

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Pros and Cons
Reviewed on April 1, 2016

I've been on spiro for two years. I started at 50 mg and was quickly moved up to 100 mg the dosage which I have stayed on. It has cleared up my skin and greatly decreased oil production. I suffered from extremely oily skin all my life, and now my skin is mostly dry, sometimes combination, but I have to moisturize constantly. I hate to say it, but I almost miss my oily skin, because it gets too dry now. I've also noticed weight gain, around 20-30 lbs! I am 30 years old 5'8 and when starting spiro I was 125-130lbs now I am well over 150 and have a lot of cellulite! I'm also extremely emotional and moody especially the week prior to my period. I'm on Trinessa as well, so maybe that has caused some of these side effects. Has anyone else experienced this with spiro? I love how my skin looks as long as I moisturize, but I hate all these negative side effects. I'm kind of torn at this point.......

Love it
Reviewed on March 29, 2016

This has been amazing to my skin!!! Hadn't been able to leave my house without makeup for years!! Now I can go to work with a bare face!! Love it! Completely recommend it. Have suffered with acne for over 10 years. It took lots of trial and errors to finally find something that worked. I have oily skin with very acne prone skin. Any little thing would break me out. Now I don't stress about it.

by lyssgirl on 03/31/2016 22:36
How long did it take for you to see results?
by BoldlyBoundless on 08/21/2016 15:28
What mg did you take?
Spiro Review
Reviewed on March 17, 2016

I am a 30 year old female who went on Mirena IUD in August 2015. Before this I would say my skin was normal, mostly blemish free. A few weeks after having Mirena inserted I noticed a change in my skin. It was horrible :( I would get pea sized cystic bumps on my hair line, neck, chin and cheek and they were very painful.

I tried doxy, with no luck and also had peels etc... in an attempt to fix this. Like most others when the problem comes from the inside you can't fix it from the outside. After reading reviews I asked my doctor to prescribe me spiro. She was reluctant but I begged.

I started the end of Jan on 50mg once daily. I took this at night. At first I did need to go to the bathroom a lot more. But with time my body has become use to this and is retaining more fluids.

After two weeks I had a week of blemish free skin. This didn't last long though and came back with a vengeance. Every day I would have a new bump on my cheek or chin. After 4 weeks I upped my dose to 2X50mg a day. The next three weeks my skin was just as bad.

I am now at 8 weeks and I haven't had a blemish in 7 days. Fingers and toes crossed the worst is over and my body has adjusted.

My advice is to stick it out. Yes it will be hard and it will get worse but for a short term break out for clear skin it is amazing.

I will update my review at the three month mark.

by lorny on 03/21/2016 11:50
Hi I'm about to beg the Dr for 'spiro' , is it expensive? I can't seem to find the price of it anywhere. Thanks & I really hope it works for you. Cystic acne sux
by SMAUS on 03/24/2016 01:07
Not at all. My bottle of 25x 100 was under $10aud. I was excited too soon. I've got some bumps again on my neck. I'm seeing the dermatologist this afternoon so will see what he has to say about it all.
Spiro didn't work for me
Reviewed on March 16, 2016

I took Spiro for 7 months. It took me from mild/moderate acne to disfiguring acne. I am 28 yrs old, I hv both cystic acne & white heads/black heads. I also have EXTREMELY oily skin. My Derm said Spiro would be perfect for me. I "purged" for an entire 7 months. Spiro seems to work for wayyyy more ppl than it doesn't so by no means do I want to discourage anyone from trying it, however, after 7 months it just appeared that it didn't work for me.

by SZW on 04/09/2016 17:59
What was your dosage?
by BinkyBunny on 05/11/2016 17:51
I am on 100mg spiro for almost two months now. My acne actually got way worse. I don't know if I should stick with it or just try Accutane. So frustrating.
Hormonal Adult Acne: SPIRO 3 months noticeable results, 6 months desirable results. AND OTHER HELPFUL INFO.
Reviewed on March 14, 2016

I am a 27-year-old female that has had issues with adult hormonal acne since I was 22. My skin is a combination of dry and acne prone. My apologies for the lengthy post, but I wanted to include other info that I found to be helpful.

It wasn’t until September of 2015 that my cystic acne was unmanageable, painful, and damaging to my self esteem in way I have never experienced. The cysts were abundant in number and size, they were large and red, eventually turning to large scabs, covering my cheeks, jawline, and my neck. Makeup was necessary but didn’t help cover much of anything except for the redness, which then appeared yellow-ish due to foundation. I am not a makeup savvy gal, so makeup was not really my friend during this time. I became highly anxious when out in public. I was rushing through my errands. I didn't want to be seen or make eye contact. If being a ghost was an option, I would've chosen to be one.

Once I discovered that this is a true medical issue that required medical attention, I made an appointment with the dermatologist. I have been to the derm several times before, but I never felt confident about my visits and treatments. Nothing *really* worked. I tried 3 different birth control pills designed to tackle hormonal acne. I became a different person each time and my body didn’t feel like it was my own, nor did my mind. I felt neurotic and my body stayed bloated despite my efforts to alleviate that. So while it did help with manage the acne, it created other problems. After the 3rd time being on the pill, I swore it off forever. I tried multiple medicated creams and gels along with antibiotics. I had also been to a few aestheticians, which did help with the appearance, but was not a true fix when the root of the problem lies internally. There was no reason to continue with the chemical peels if it wasn't actually contributing to my "cure".

However, my new dermatologist had a different approach. I was involved in the choosing and planning of treatment. She explained and reviewed options with me (yes, she gave me options!) and provided me her professional input for guidance in my decision making. I didn’t think that my acne was Accutane worthy, and even if it were, I was very hesitant. After careful consideration, I decided to go with Spironolactone (50mg) taken once daily to and Tretinoin (retin-a) cream at night. I felt SO great about this and eager to start. After the first 6 weeks, I had to have my blood drawn and tested for normal potassium levels. I did notice breast tenderness and light headedness when not taken with food, so beware of that! These symptoms are common as you while find in the other reviews here.

In February of 2016, I had a derm appoint for a progress report. At that time, we decided to adjust the Spiro dosage to 100mg taken twice daily plus the Tretinoin cream applied a night. 

It is now the middle of March and *knock on wood* my skin has radically improved. I rarely ever get breakouts, except for PMS related. Everyone wants quick and perfect results, which might be an impossible achievement. I am very happy with the progress I have seen thus far and am willing to stay on the Spiro train. 3 months for noticeable results, 6 months for desirable results. BE PATIENT AND STICK WITH SPRIO!!! The next phase for me is to heal the discoloration and scarring.

I have not noticed a change in mood, but maybe I should ask my S/O for his observation. My menstrual cycle has always been regular on a strict schedule according to my body' natural clock. End of the month for 7 days. Now it's more like, ehhh every 2 to 3 weeks lasting anywhere from 4 or 7 days, but I don't necessarily consider that to be a CON. I just deal with it per usual. I have always drank a lot of water, consequently going #1 pretty frequently. I haven't noticed a change in my restroom habits.


Disclaimer: We are all delicate snowflakes and what works for me will most likely not work for anyone else quite the same way. Hopefully you can’t get some ideas from this though!

I also wanted to mention that I became mildly obsessed with ridding my acne because of the effects it had my self esteem. I would normally consider myself a social person, but became recluse when the acne was at it’s worst in September. Because of my obsession, I did countless hours of my own research. Which is how I came to find this website/blog fyi. I read review after review after review. I watched video bloggers that had videos related to adult acne. I read articles written by industry professionals and other blogs. I read product reviews on the internet. I arrived to the conclusion that hormonal acne MUST first be dealt with internally. 

After diving into my research, I reflected on my dietary habits. I always made an effort to eat relatively healthy, but zero effort to really say “no” to sugar, salt, and dairy. It was time for me to use my willpower and commit to sticking to a healthy diet rich in fruits, grains, and vegetables. I had to turn my back on my sweet tooth. No longer could I give into my chocolate, chips, candy, pizza, ice cream, cheese, pretzels, etc. Yes, I do eat these things still, but only on a rare occasion and not in excess. I used to eat an entire tub of chocolate ice cream in a few days time because #yolo.


Organic and natural products have lasted the test of time for a reason. If you’ve never done so, try an experiment in which you DON’T purchase or use products that have unnatural ingredients. If you don’t recognize the name of an ingredient, don’t buy it. If you don’t have a nearby store that offers these options, or maybe they do but they are pricey, try Amazon. You can also make your own products from a few simple ingredients! Remember, just because it’s a high-end fancy name brand jar or tube, doesn’t mean it works. There are ALWAYS natural inexpensive alternative options (that are usually must cheaper).

Other foods/products that help with acne:

Citrus fruits

Tea tree oil

Raw honey


High iron foods- mostly anything green (i recommend asparagus, kale, spinach, cucumbers)

Apple cider vinegar

Cayanne pepper




Egg whites

Ginger root

Jajoba oil

Shea butter

Coconut oil
Rosewater toner
Brown sugar (for scrubs)


Peppermint essential oil

Herbal tea

Baking soda

Red potato skins

Vitamin C products (serum, lotions)

Vitamin A products (ditto)

This list is a mix of things that can either be ingested, applied superficially, or maybe both. I found tons of uses for these from kind internet folks (ie.: make facial masks, wash skin, wash hair, skin care regimen, etc.). Youtube and Google has everything. Thanks internet!


OMG GET ONE. My derm recommended I look into this product. I knew some friends that had one and swore by it. The only thing is, they are costly. I’m the first to admit that I am a girl that balls on a budget and couldn’t justify the expense. BUT after Christmas I pulled all of my new and old Sephora gift cards together to buy the $150 item and ended up only spending $40 out of my own pocket to finally have one. I am telling you that Clarisonic WORKS. I use an all natural oil based facial cleanser with it twice daily and I immediately noticed the change my skin. If you are able to afford one, please do yourself a favor and get it. Other similar products from different brands could be just as effective, but I can’t vouch for those.

Lastly, before buying products online or in-store, I encourage you to read reviews, search for answers to your questions, look on youtube for product reviews before spending your money no matter the cost!

by BinkyBunny on 05/04/2016 23:01
Thanks for shareing. My derm gave me 100mg once a day plus Retain-A 0.0245% to use at night. It has been one month, and my acne has never been worse!! :( I got lots of big red ones around my mouth. I normally got one or two, but never this many. So frustrating. Did yous got worse before it get better? thanks!
by BinkyBunny on 05/04/2016 23:01
Thanks for shareing. My derm gave me 100mg once a day plus Retain-A 0.0245% to use at night. It has been one month, and my acne has never been worse!! :( I got lots of big red ones around my mouth. I normally got one or two, but never this many. So frustrating. Did yous got worse before it get better? thanks!
by BinkyBunny on 05/04/2016 23:01
Thanks for shareing. My derm gave me 100mg once a day plus Retain-A 0.0245% to use at night. It has been one month, and my acne has never been worse!! :( I got lots of big red ones around my mouth. I normally got one or two, but never this many. So frustrating. Did yous got worse before it get better? thanks!
My miracle
Reviewed on March 1, 2016

Don't know if anyone has checked this lately but honestly, I tried everything for my acne until I tried spironolactone(aldactone) my chin, cheeks, jawline and part of my neck were breaking out ... I hated my skin. I tried spiro and started at 25. then progressed to 100mg. A day.. My acne literally disappeared. My periods yes were irregular, and I did not gain any weight. I actually lost 10 pounds.. I went off of it for a year cause my skin was fine. I also already have low blood pressure and this medicine does lower it so I was feeling cold and sleepy at times. My skin was terrible the whole year I was off of it. I literally would not leave my house because I didn't want anyone seeing my face ... Went back on the Med only at 50 a day and I'm back to blemish free and have regular periods and only get tiny ones during my cycle. This has been the only medicine that's ever helped me and I've taken doxycycline, all the antibiotics, even regimens. Anyway, Come to find out I had cystic ovaries and my hormones were whack. So I'm happy i found this medicine because it helps my cramps and my skin 98 percent. Of the time :) also to mention; those who aren't seeing any results after 6+ months.. If your acne isn't hormonal, as in caused by your hormones being whacky, then this will not help. This medicine as my doctor said is; an androgen blocker, sebum (oil) is reduced because your testosterone (androgen) is being blocked. Excessive sebum is why your pores become clogged, and yes you must avoid excessive potassium because this medicine is potassium sparing( it stores it) so anyway. Everyone will have a different reaction, I did not gain weight like everyone else mentioned, I lost 10 pounds actually, and it helped with my cramps and periods. Although when I was on 100 mg a day I was having some off periods.. And was a bit sleepy and had to pee a lot!

But all in all this medicine has been amazing to say the least.

by tessie on 03/01/2016 07:46
Also to add, I've been on this for 5 months now.
by steefinkys on 03/02/2016 20:22
Are the cystic ovaries a result of the medication?
by lyssgirl on 03/03/2016 05:58
How long did it take for you to see results after restarting the medication for the second time? I made the mistake of going off of it, though only for 2 months, and started breaking out. I've been back on it for a month and praying it clears me like last time.
Finally something that worked!
Reviewed on February 11, 2016

After 14 years of struggling with acne and trying everything under the sun, I am happy to say that my acne is almost completely gone with the help of spironolactone. I am kicking myself for not visiting a dermatologist sooner. I have been taking this medication for three months now. When I first began taking the medication I was prescribed 50 mg a day, in addition I was prescribed a benzoyl peroxide face wash for the morning and a Aczone topical, and in the evening wash with a gentle facial cleanser (I chose Cetaphil) and Ziana at night. Prior to this regimen, it was not uncommon for me to wake up with a minimum of 3-5 new pimples, many of them deep and painful. Within 2 weeks there was a significant change with the amount, frequency and type of pimples I would have. I would wake up with a pimple or two sometimes. During that first month I think I only had six pimples maximum. And they weren't mostly cystic, it was primarily little whiteheads, one cyst during my menstrual cycle. After the first month my dermatologist kept my regimen almost the same, only increasing my dosage of Spironolactone so I can hopefully clear up completely, I take 50 mg twice a day. Luckily I have not yet experienced any side effects during the course of using this medication and breakouts are incredibly rare, only a cyst or two around my period. I am so thankful that I took my dermatologist's recommendation! This has greatly improved my confidence and drastically reduced the time it takes for me to get ready in the morning. I don't have to spend an hour just trying to cover up acne anymore, it takes me fifteen to twenty minutes to put on a full face of makeup and run out the door and I don't feel like I have to hide anymore.

My Deep Acne is Gone
Reviewed on February 10, 2016

I'm 24 and I've struggled with acne and cynical acne since puberty. And, as I've gotten older, it has only gotten worse. Most of the acne was concentrated on my cheeks, jawline, chin, and neck.

I started on 25mgs for the first three months. There was quite a bit of improvement, but I still had some breakouts. It seemed like with every period cycle I would breakout out before my period, but then after, it would be much clearer than before.

At my three month dermatologist appointment, they upped me to 50mg. Now, after six months on this stuff I'm completely acne free! And, it has been YEARS since my face has been this clear.

I'm also on Aczone in the morning and Epiduo Forte at night.

At the beginning, I did stuffer a few side effects like low blood pressure/dizziness and loss of appetite. But, by taking the medication at night, it reduced the side effects to practically nothing.

If you're struggling with hormonal acne, I'd really give this a go. It's helped me out tremendously. It takes awhile complete clarity, but the results are definitely worth it.

by ekrieger on 02/10/2016 17:37
did you have an initial break out?
Getting off after 2 months of non-stop break outs and mood swings
Reviewed on February 4, 2016

ADVICE/INSIGHT WOULD BE GREATLY APPRECIATED! I have been on spironolactone for 2 months now. Here is what my experience has been like: new breakouts every day (one pimple at a time, sometimes clumps), horrible mood swings, some depression, acne in places I've never had it before, slower healing skin, darkening of all the hyperpygmentation on my face, nausea, and that's just to name a few. Heres some background information about me: I am a 21 year old college student. I always had good skin, probably one pimple on my face normally, if not clear. Around my 21st birthday I began to get ugly, long lasting deep pimples (not cysts but under the skin) around my period. My derm prescribed me this and from the 2nd week I took it the breakouts started. Deep cysts, followed now by just pimples popping up everywhere. I can't keep up with my skin and the stress it has caused me. Tomorrow I am going to my derm and I am going to try Bactrim for a few months to combat the breakouts I will probably get from getting off the medication. I also started aczone which has helped prevent new breakouts so far. I believe spiro was too strong of a medication for me to be put on. It fluctuated my hormones so severly that I am not sure if I will ever feel/look normal again. My advice, if you are young (25 and below), your hormones may not need another factor effecting them. I am hoping the best for this antibiotic but if not I am doing a low dose round of accutane. I apologize if I seem negative, however this has been the roughest 2-3 months of my life, I have little self confidence and I find myself avoiding going to class, seeing friends, and even seeing my boyfriend. I am sure for PCOS and older women, this drug is a miracle worker. However for me, it amplified the awful hormonal imbalances that I am facing at this time in my life. If you have had a similiar experience, or are my age and having these problems, please reach out. I also understand this medication can take up to 6 months to work, however my skin has already completely changed from it. I can hardly keep my pores unclogged, and while it has cut my oil production in half, my skin looks like a hyper pigmented mess and still produces acne (cystic included). Again, I apologize for the negativity and I hope all of us can find a way to manage our acne.

by TaneBabe on 02/10/2016 01:16
Just wanted to update for any people looking at this: I stopped spironolactone about 5 days ago, started Bactrim 6 days ago and the breakouts have almost completely stopped. Not just a bunch of acne marks and PIH, ugh. So glad I found what was causing my acne!
by Bonnie Armstrong on 02/14/2016 02:41
I am currently going through this right now. Please keep me posted on what ends up working for you!
by TaneBabe on 04/07/2016 19:41
Hey Bonnie! I know it has been a couple months but I ran across my review and wanted to update. After stopping spiro, my acne and overall skin condition dramatically improved. I stayed on Bactrim for almost 2 months and am now 23 days into my course of Accutane. I have only a few congested pores and some red marks left now, but this experience taught me that this medicine is not for people as young as me (21) or people with no signs of testosterone imbalance. How are you doing?
Reviewed on January 29, 2016

Has cleared up all of my acne and I'm only on 50 milligrams. my scars are starting to fade too!! so happy with the results

by TaneBabe on 02/04/2016 22:04
I have a few questions: how old are you? do you just take it once a day? how long did it take you to see results?
by alysiajackson on 02/25/2016 18:34
ive read that it gets worse at first before getting better taking this medicine, did yours do that?