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Active Ingredients:
25 mg, 50 mg or 100 mg of Spironolactone.

Inactive Ingredients:
Calcium sulfate dihydrate, colloidal silicon dioxide, croscarmellose sodium, crospovidone, hypromellose, lactose monohydrate, magnesium stearate, peppermint flavor, polydextrose, polyethethylene glycol, povidone, pregelatinized (corn) starch, sodium lauryl sulfate, titanium dioxide and triacetin.

Items marked with orange can be irritating and over-drying, especially to acne-prone skin.

The list of ingredients above is provided for informational purposes only. Always check the actual product label in your possession for the most accurate ingredient information due to product changes or upgrades that may not yet be reflected on our web site.


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Takes a while and not without side effects
Reviewed on July 14, 2015

I started taking spiro at 25mg per day. I didn't see a bit of difference after a bunch of weeks, so I wondered if I should bump it up to 50mg. However, I read a lot of other reviews that advised waiting. So I waited and waited. I took like 4 months to start clearing. Finally 6 months later I am 100% clear, I never have to wear makeup, and I only get 1 or 2 little spots before my period, which I can live with. However, it is a diuretic - I get low blood pressure, have trouble standing up, and I have to pee like 14 times a day. I also got the worst cellulite on my legs - soooo bad. I personally wouldn't go higher than 25mg, it's an androgen blocker and my testosterone was extremely high and my other androgens were literally off the charts they were so high (I have PCOS). So if you are wondering if you need to go up, be patient, and be prepared for some pretty awful side effects. My thoughts are, I can cover up the cellulite on my legs by wearing pants, but its harder to cover up your face. That said I will probably stop taking it soon and try saw palmetto as some others have suggested.

Too soon to tell but hopeful..
Reviewed on July 2, 2015

I am a 22 year old female and have had pimples here and there for most of my teen years. December 2014 my skin was gorgeous, clearer than it has ever been and then came January.. All the sudden the skin around my mouth erupted in rash like bumps and then progressed to acne -looking bumps as well as cysts that moved down to my chin/ jaw and up along the sides of my nose & even under my eye ( which swelled shut at one point and turned black & blue due to a cyst). I was told by 4 different doctors that I had perioral dermatitis & was put on antivirals, antibiotics, topicals and had blood work and cultures taken of my skin. No luck. I finally saw a dermatologist who put me on more antibiotics (100mg) for 2 months which did nothing but give me UTIs. After a second visit with him last week, and zero improvement (despite trying every holistic treatment under the sun, including going sodium laurel sulfate -free) he put me on spironolactone. It has been 1 week and my skin is nightmare-ish right now. I have multiple cysts and my chin is covered in painful spots. I feel so depressed, my confidence is shot and most days I can't bring myself to leave the house. I hope and pray my skin starts to improve soon. After 6 months of this constant physical & emotional pain, I don't know how much more I can take. Anyone have a similar experience? Or advice?

by sbeanie82 on 07/04/2015 21:40
I had a terrible cystic breakout a couple weeks after I first started spironolactone (way worse than my usual cystic acne), but about a month in my skin started clearing up. My skin has been almost completely clear for months now!! I've heard it's common to have an initial breakout on spiro, so I'd recommend sticking with it. don't lose hope!
by ko12345 on 08/03/2015 20:19
Sbeanie82 -- what dosage were you on?
It's ok, but...
Reviewed on June 22, 2015

So I have been on it for over 11 weeks and there have been improvement in my skin however I have been getting my period every other week, not exaggerating! Then after my last period it went 8 days and started up again! I stopped taking it for a few days and I have been getting really bad headaches, not sure if that's related. I see others comments but no one really stated about if they have had messed up cycles and if that went back to normal...

Incredible results!!! Finally cured.
Reviewed on June 10, 2015

I have struggled with acne for 10 plus years, with waxing and waning severity. At 23 years old, I was tired of always being self conscious of my face. After only 2-3 months on Spironolactone, my skin became completely clear. Now almost 6 months later I have perfect skin. I barely need to do anything to it anymore, just simple washing and mosturizing. I have had almost no side effects, some mild light headedness in the beginning. Also, I finally shed the extra 15lbs I had gained over the past few years! Now I look and feel amazing, and recommend this treatment to any of my female friends who stiff suffer from acne after their teenage years. :)

by ko12345 on 07/21/2015 16:33
How many mg are you on?
Very good at clearing acne, but the side effects are terrible.
Reviewed on June 7, 2015

Well, sprionolactone did work well for clearing my acne. I've been on it for almost two months, and my face is completely clear and was completely clear towards the end of the first month. But I'm now having to get off of it because of the serious side effects I've had. The less serious side effects started as soon as I got on the medication, but I brushed them off in hopes that they would subside as I continued the medication. But as I started the second month, almost two weeks in, I got up one morning and my right leg was completely numb. Not asleep or tingly, completely numb. Hahaha. (It's really not funny, but it's making me laugh now because I was in a huge rush, so I JUMPED out of bed, and fell immediately to the ground. Several times hahaha.) Anyway, It's so easy to stay on meds for acne cause it sort of feels like a one stop shop. No need to change your diet, don't have to be too careful about what you wash your face with, at least that's how it was for me. I've always been a natural person, trying to cure anything I had with natural remedies, supplements, internal cleanses, all that good stuff. And it all worked until my skin decided to go absolutely crazy. I started breaking out like normal, probably something you could clear with a good cleanser, but then it started getting progressively worse. It started to be more cystic, and then really before I could even keep up with it, I had horrendous cystic pimples everywhere, and I mean everywhere. Shoulders, down my arms, all over my entire face, even sometimes on my thighs. It was ridiculous and I always felt gross. So I broke down and gave up my ideas for natural cures for a while, and got on the meds. They cleared me right up! About one month and almost everything was gone. But then of course I had the terrible side effects, which is why I'm now having to get off. My sister on the other hand had no side effects at all. Everyone is different. So, hopefully I can find a natural way to keep it clear from now on. Good luck to anyone trying:)

Better but not perfect
Reviewed on June 4, 2015

I have moderate stubborn acne and even though it didn't clear me up, it did make my breakouts less frequent. At any given time I would have about 10 pimples on my face and while this I'd only have about 4 or 5. It's definitely for hormonal acne though. I did only take it for a month though before trying something else so maybe I just didn't give it enough time.

This medication saved my life. Figuratively, but almost literally.
Reviewed on May 27, 2015

I've suffered from adult hormonal cystic acne for the last 7 years, ever since my senior year of college. I've tried absolutely everything: all kinds of topicals, supplements, birth control... nothing worked. For a couple of years, the regimen kept me somewhat in check, but I still got big, painful, itchy zits. At one point when I went off the regimen, my face broke out so badly that I went back on the regimen and completely overdid it, far beyond Dan's recommendations. Well, I ended up with an actual chemical burn on my face that caused EXCRUCIATING pain for 3 months. Yes, you heard me. 3 months. And then, the acne started coming back, and I couldn't cover it with makeup. I was mortified. I didn't want to live anymore. I ended up on disability from work due to severe anxiety and depression due to an acne dysmorphia that caused massive breakdowns throughout the day. I couldn't focus on anything. I felt so lost and hopeless, like no doctor would ever help me figure it out, and the pain on top of it was unbearable. I tried to kill myself, it was so bad.

Now, in June before the chemical burn happened, a new doctor had started me on 50mg of Spironolactone. I'd been on it for only 2-3 months at the onset of this disaster, so I knew it wasn't likely to be working just yet. I was in agony, constantly praying it would start to work. After around month 3, I asked my doctor to up me to 100, which had about the same results. Finally, in month 7, she agreed to up me to 150mg. Within weeks, I had stopped producing new pimples. I had finally found my magic number. I watched as my face began to clear, and my scars continued to lighten with it. At the same time, my chemical burn had stopped hurting and was starting to show slight improvements. I had already started to get better about my acne dysphoria, but finally seeing the itchy, painful, unsightly problem go away took so much stress and worry off of my mind.

I do still get small pimples here and there--even some that are fairly deep, but there are days where I will miss taking my spiro, as well as times I pick at things I shouldn't, so I completely blame those on myself. I do still have some healing to do from the chemical burn as well as some indented scars and hyperpigmentation that has been present for over a year since the initial big breakout, but I've been working on them with a dermaroller and vitamin C serum. Not sure if the roller really does much, but the serum definitely has improved things for me. I highly recommend it as part of anyone's nightly routine.

Anyway, it is so much better than it was, if I think about it too much I could cry at the relief. I can scratch my chin mindlessly if it itches, now. I can snuggle up to someone without worrying that their dirt will give me a zit (which didn't turn out to be true, anyway). I can run to the store for something I forgot without feeling like I have to endure a 20-minute makeup routine just to feel okay enough to go.

I ABSOLUTELY recommend trying spiro if your acne appears to be hormonal (around the chin and mouth, possibly deep and cystic feeling, painful, spiking at a certain point in your cycle, etc.), and if you're not planning on getting pregnant (it's not good for the baby/pregnancy, as it directly affects the expression of hormones. I was fine with this, as I'm in a lesbian relationship and have no intentions of ever carrying a child via artificial means). It took me about 5 months to find the right dosage with my doctor and see the real results, and trust me, it was HORRIBLE having to wait. But it was so, so worth it. Please try it, please stick to it. It saved my life.

by Brittz0rz on 05/27/2015 19:48
I should note that the reason I went off the Regimen in the first place was due to some dehydration that was going on that no amount of moisturizer would help. I wanted to not only cut out the BP (which my skin was clearly too sensitive for in the long-term), but also cut down the amount of time it took me to get ready for work/bed.
by KlC89 on 05/31/2015 17:19
Reading this has given me some hope in this long and painful acne situation I have been stuck in for 14 years. Very much similar to my situation including the body dysmorohia associated with the worsening of acne and not wanting to go to the store because of the make up routine beforehand. Spiro is really my last hope
by KlC89 on 05/31/2015 18:06
Reading this has given me some hope in this long and painful acne situation I have been stuck in for 14 years. Very much similar to my situation including the body dysmorohia associated with the worsening of acne and not wanting to go to the store because of the make up routine beforehand. Spiro is really my last hope
Works, but at a cost
Reviewed on May 12, 2015

My derm put me on Spiro to get rid of the cysts on my chin after switching from birth control pills to an IUD.

I hated it. It worked, after two months I had no cysts, but I was SO dehydrated. I could not keep enough water in me. Felt like I had to pee all the time, was constantly worried I had a UTI, etc. Went to my primary care physician twice because I was convinced I had a UTI, and both times it came out negative. I stopped taking it after 2 months and thankfully, the cysts were completely gone after that.

My Spiro Journey (weekly update)
Reviewed on February 21, 2015

I'm really hoping it works! I've been on Accutane, but that was 5 years ago. Since then, my skin never came back to what it used to be. For 4 years i had pretty flawless skin, but this last year i had a hard time trying to fix my skin. So here i am, still trying to fix it . Let's see if it works!

Keep in mind i have fair to medium skin, with yellow undertones and it used to be SUPER (cant stress this enough) oily skin, but thanks to Accutane i have combination skin now.


***WEEK 1: breaking out a little more than usual; no noticeable reduction in oiliness; pimples healing INSANELY fast even though i get new ones almost everyday; terrible headache in the first day (so i don't even know if it was because of spiro)

***WEEK 2 (PMS week): at the beginning of this week i was breaking out like crazy but in the last 4 days i got only one small pimple; NOTICEABLE reduction in oiliness; pimples healing reeeally fast; terrible stomachache yesterday

***WEEK 3: skin was doing GREAT at the beggining of this week, but 3 days ago i started breaking out again, it's not a huge breakout though; NOTICEABLE reduction in oiliness; pimples healing fast; my period didn't come this month

***WEEK 4: skin was doing GREAT but today i got a new pimple, a big one, but it is smaller than the huge cysts i was getting before i started Spiro; noticeable reduction in oiliness; pimples healing fast

***WEEK 5: skin healing from horrible breakout i had this last weekend (maybe beacause i upped my dose to 150mg); noticeable reduction in oiliness; pimples healing fast

***WEEK 6 (PMS week): skin is doing GREAT, it feels like it was purging and now there is nothing more to come out; INCREDIBLE reduction in oiliness; pimples healing fast

***WEEK 7: skin was almost flawless in the beginning of this week but since yesterday i got 2 pimples (one medium and one small); incredible reduction in oiliness; pimples healing fast

***WEEK 8: awesome skin!!! NO new pimples this week (since i haven't reached the 3 months mark, there's a chance i break out again though); oiliness is GONE; pimples healing fast

***WEEK 9: FLAWLESS skin ( better than when i was on Accutane!!!!!!!!!); oiliness is gone; can't tell if pimples are healing fast because i haven't got any new pimple this 2 last weeks

***WEEK 10 (PMS week): Awesome skin (no new pimples at all); oiliness is ok (maybe beacause is pms week); once again cant tell if pimples are healing fast because I haven't got any new pimples this last 3 weeks

***WEEK 11: after weeks without having any pimples i got a little one yesterday but it's already clearing up (but this was one of the most stressful weeks of my life, so keep that in mind); pimple is healing pretty fast; terrible stomachache (but i also think is stress related)

***WEEK 12: got a new pimple this week, but its a little one; oiliness reduced; pimples healing pretty fast

by adwhite17 on 02/22/2015 00:22
I started Spironolactone a little more than month ago for my hormonal acne, and I was told by my doctor to be extremely patient with it, as it could take months before I see any effects. As far as your breakout, it seems a bit soon and could just be your skin misbehaving. Good luck and do keep us posted!
by Natalia P on 04/18/2015 22:00
Hi I was just wondering did you experience any weight gain, at all, from the spire?
by robertathaise on 05/13/2015 23:01
eu acabo de descobrir que tenho ovario policystico , esse eh o problema da minha acne, depois de deixar de tomar diane 35 . estou usando accutane por quase 2 meses e estou gostando… minha boca fica seca e tenho que beber muita agua , quando minha menstruacao vem minha pele piora um pouco e por isso estou tomando a spirolactona….
20yo on Spiro feeling impatient
Reviewed on November 22, 2014

Hello so I will be 30 days on Spiro 50mg a day on 11/27/14 I haven't noticed an impact yet but I am trying to stay patient even though their are days I feel hopeless.. a bit of background of myself I will be 21yrs old in December I was on the birth control implanon (implant on arm) since 2012 of june recently got off of it in May 2014 because I wanted a break from b.c but I have never suffered from acne problems just the normal breakout (2-3 small ones a month) just started breaking out in the end of august 2014 lower of my face mild acne around mouth on jawline n chin so I figured it had to be hormonal sincr I got off the implanon so my gyno put me on orthotricyclen lo I been on that since Sept 21, 2014 but I still have mild acne on lower of my face get new pimples evevery day can SOMEONE give me SOME ADVICE OR SHARE THEIR EXPERIENCE WITH spiro. Please and thank you I have become so unhappy and my confidence has decreased alot!

************8months on pill

Hello everyone so I have now been on spironolactone 50mg a day for about 8 months now i did have an initial break out but after the 4month on it i cleared up i didn't have any breakouts just a few small ones that werent noticeable i do still have my red n dark marks from post acne but recently i have noticed that i have been gettin new ones out of nowhere and Im scared that my skin will go back to what it was..I only missed one pill which was on april 27th so what i did was take 2 pills the next day since i missed one the day before..could that have anything to do with why im starting to break out? Can someone plz help me or give me some advice, im freakin out

by hll406 on 11/22/2014 15:25
I am 35....benn on Siro 50mg 2x/day for 1.5 months and have noticed nothing except constipation and about a 2 pound weight loss. Should I really keep going?
by brinyoung on 11/23/2014 05:46
Spiro notoriously takes a while to kick in, just like any hormonal treatment. But keep going! Spiro is the only thing that eventually cleared my acne completely.
by bm93 on 12/01/2014 05:27
I still keep getting new acne and have many red and dark blemishes from the cystic acne that I was gettin everyday..just trying to hang in there! I hope to see results soon! Today marks my 33 day n spiro 50mg
by gmailgrl on 12/05/2014 04:14
stay hopeful! 6 months after starting, along with yaz and I haven't had a breakout since! it's been over a year now! I still take it faithfully!
by bm93 on 12/12/2014 05:13
I hope too see full results soon staying Patient!!! Also my dermatologist prescribed me bactrim its an antibiotic pill that im taking twice a day she says it should help speed up the process plus im using retin-a at night! I hope this works, good luck to everyone!
by tbos94 on 12/13/2014 03:58
Stay patient! This medicine worked really quickly for me, but this medicine works for females with hormonal acne. My acne was severe, so if yours is mild and have been experience some acne it may just be because of getting on and off birth control. But, give it more time!! Don't be impatient because all medicines especially acne topicals and medicines take weeks to a few months to really start working.
by bm93 on 12/13/2014 19:07
Sinve alot of ppl on here are taking 100mg a day should I tell my dermatologist to put me on a high dose since im jus on 50mg a day or stay at 50mg because im pretty small I weigh 115lbs and im 4'11 in height