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#3443186 Questions For Fredthebelgian About Vit A

Posted by Jofo on 24 July 2014 - 01:46 PM

Jofo, what would your opinion be on this Vitamin A supplement? http://www.nowfoods....00-Softgels.htm


I'm just about to start taking them, was wondering if I should be worried about anything?

Thanks a lot


That's the brand that I'm taking (except mine is 10,000 IU per pill), and it's also the exact supplement that FredTheBelgian said he has been using for a couple of years with no side effects. I emailed Now Foods and they said that it is 100% fish oil sourced Vitamin A, not synthetic. So I think it's a pretty safe bet as far as vitamin A supplements go, but if you have any reservations you can of course let me be the guinea pig here and see how my body responds to the supplement before trying it yourself.

#3441900 Questions For Fredthebelgian About Vit A

Posted by Jofo on 17 July 2014 - 11:10 AM

On July 2 I started taking 1 tsp. of cod liver oil per day, then one week later I decided to add 20,000 IU of Now Foods Vitamin A (the brand that FredTheBelgian uses) to help speed up the process. I haven't seen any changes yet, but back when I was on isotretinoin it took 3 weeks for the sebum-reducing effect to kick in, so I'm going to be patient with this regimen.

#3440016 Questions For Fredthebelgian About Vit A

Posted by Jofo on 07 July 2014 - 11:33 PM

Yes, I just started taking cod liver oil. There's no way to tell exactly how much vitamin A I'm getting but I'm shooting for at least 20,000 IU. I'll definitely update with my results in the coming months.


Have you had a look at these Vitamin A drops, Jofo? http://www.amazon.co...words=vitamin a


The 'Most Helpful Customer Review' explains why he/she thinks this is one of the best types of Vitamin A available and it's quite convincing- just wanted to know your opinion on it? smile.png


To be honest, I only just started looking into vitamin A a few days ago so I'm not an expert by any means. That particular supplement may very well be totally safe in large doses. Personally I'm trying to stick mostly to natural sources for my vitamin A, at least until I can do some more research.




Jofo, do you plan to try taking vitamin A? If so, please let us know how it goes! I was concerned about toxicity, but now it sounds a lot less harmful than I thought.


Yes, I just started taking cod liver oil. There's no way to tell exactly how much vitamin A I'm getting but I'm shooting for at least 20,000 IU. I'll definitely update with my results in the coming months.

Are you concerned at all about vitamin D toxicity? I was deficient in vitamin D and started taking it every day and my levels became too high. I'm nervous the same would happen with the cod liver oil.


No, I'm not concerned. As a general rule, your body handles vitamins from natural food sources much better than it handles synthetic vitamins in supplements, so the toxicity threshold is much higher. Most vitamin D overdoses come from the synthetic supplements.

#3439080 Questions For Fredthebelgian About Vit A

Posted by Jofo on 02 July 2014 - 04:30 PM

Would you happen to know approximately how much Vitamin A is in each Green Pastures supplement that you've started using? I can't seem the find any actual amount in units on their site :/


Green Pastures stopped listing vitamin content on their labels because it varies from batch to batch, but I did find this snippet from an article on their website:


"The final category is the fully cleaned and deodorized product with natural vitamins added back in. This is the so-called high-vitamin cod liver oil, standardized at 2340 IU vitamin A per gram (11,700 IU per teaspoon) and 234 IU vitamin D (1170 IU per teaspoon). This is the type of cod liver oil I imported into the U.S. and sold under the Blue Ice label"



My guess is that the amount is probably less precise than that, so I emailed the company and asked if they could provide a general range of vitamin A content. If I hear back from them I'll give an update.

#3439068 Questions For Fredthebelgian About Vit A

Posted by Jofo on 02 July 2014 - 03:18 PM

Excellent post Jofo! That should shut up some of the scaremongers who think you're going to kill yourself if you take vitamin A megadoses.


Thanks! Yeah that study definitely helped put my own mind at ease.


And I should point out that some fish/cod liver oils have the natural vitamins removed and then have synthetic vitamins added back in, which means they could still become toxic at relatively small doses. So to anyone considering a vitamin A megadose, don't assume that a particular supplement has naturally occurring vitamin A just because it's from a fish oil. I believe the Carlson brand, for example, sells cod liver oil that contains synthetic vitamin A. I'm using the Green Pastures brand because they specifically state on their website that the oil contains natural vitamins.

#3438960 Questions For Fredthebelgian About Vit A

Posted by Jofo on 02 July 2014 - 01:50 AM

For anyone who is interested in vitamin A megadosing but is worried about toxicity, I found an interesting study that should help allay your fears. The study performed a meta-analysis of around 250 scientific papers related to retinol, and there are basically 3 important takeaways:


1. Naturally occurring oil-based vitamin A is roughly 10 times less toxic than synthetic vitamin A.

2. The upper limit of oil-based vitamin A for an individual is about 6666IU/kg/day. In my case, for example, this comes out to just over 453,000 IU.

3. Vitamin D dramatically reduces the toxic effects of vitamin A, and consequently raises the safe upper limit of vitamin A that you can take. The study unfortunately doesn't specify how much vitamin D is needed.


Personally I've chosen to go with fermented cod liver oil in liquid form for my source of vitamin A.


Some choice quotes from the study relating to what I paraphrased above:

  • "water-miscible, emulsified, and solid preparations of retinol are ≈10 times as toxic as are oil-based retinol preparations.”
  • “Chronic hypervitaminosis A is induced after daily doses of 2 mg/kg/day of retinol in oil-based preparations for many months or years”
  • "Clinical studies of secondary cancer prevention indicate that daily doses of 90 mg retinol in oil-based preparations in adults (≈1–1.5 mg/kg) are well tolerated for many months or years”
  • “Vitamin D appears to protect against retinol toxicity because the median dose was significantly higher when the vitamins were combined (0.7 mg/kg; P = 0.020; 95% CI: 0.082, 1.56 mg/kg).” [that's 2333 IU per kg more]


#3438166 Questions For Fredthebelgian About Vit A

Posted by Jofo on 26 June 2014 - 09:20 PM

I saw it was decreasing then it stayed pretty much steady so I take my 25000 IU and don't worry about it.


I will try to take only 10000 IU in a few months and see if it's still effective.


If you do try the 10,000 IU dose, please report back with your results because I'd love to know if it works. It's funny, I've seen lots of your posts around here but somehow missed your thread about vitamin A curing your oily skin, and it just convinced me to try vitamin A for myself.

#3437539 Very Low Dose Accutane For Oily Skin

Posted by Jofo on 23 June 2014 - 07:38 PM

It worked for me. I took 10mg of Isotretinoin every day and my oil production decreased dramatically. I made a log 3 years ago describing my experience: http://www.acne.org/...-for-oily-skin/

#3377801 Summary Of The Solutions Proven To Work For Oily Skin

Posted by Jofo on 25 August 2013 - 01:44 PM

I’ve compiled a list for my own research regarding topicals that may help reduce sebum, and I decided that I may as well post it here since it might be helpful to others.


I’m about to start using a combination of two shampoos and a cream that contain a number of these ingredients, and I will of course make a thread if I see a reduction in my sebum. If anyone else is feeling adventurous, please consider trying some of these topicals for yourself. The only way we will ever find a solution for oily skin is if we experiment.


Green tea (camellia sinensis)

60% reduction of sebum after 8 weeks using a formulation containing 3% green tea extract:



“Twenty mg of (-)epigallocatechin gallate (EGCG) in 0.2 ml 70% ethanol was applied to the left forehead twice a day for 6 days (FIG. 25). The L/R ratio decrease from 1.20±0.02 to 0.71±0.04 during this period . . . Clearly EGCG was more effective in reducing the sebum production from forehead than (-)epicatechin.”



“we examined the effects of EGCG, the major polyphenol in green tea, on human SEB-1 sebocytes and in patients with acne. In SEB-1 sebocytes, we found that EGCG reduced sebum”



 “Steady and statistically significant reductions in sebum secretions were noted for mono (green tea) and combined treatments (green tea plus lotus) compared to placebo treatment.”



Ketoconazole (Nizoral)

“The sebum casual level appeared to be decreased by KCZ”

“A 19.4% decrease in the mean sebaceous gland area was observed in the KCZ group”

[Yes, the ketoconazole decreased the actual size of the sebaceous glands.]



“The sebum excretion rate is reduced with ketoconazole (-6.54%)”



Sea buckthorn (hippophae rhamnoides)

“Concentrated sea buckthorn (H.rhamnoides) fruit extract was entrapped in the inner aqueous phase of w/o emulsion. . . the Formulation showed statistically significant (P < 0.05) effects on skin sebum secretion.”



Licorice (Glycyrrhiza inflata or glycyrrhiza glabra)

Among the herbal extracts tested, polyol-soluble licorice extract P-U (product name) derived from Glycyrrhiza inflata showed the most potent testosterone 5 .ALPHA.-reductase inhibition, androgen receptor binding inhibition and antimicrobial activities, which are closely related to sebum secretion. In addition to the findings on polyol-soluble licorice extract P-U, clove extract and peppermint extract showed testosterone 5 .ALPHA.-reductase inhibition, arnica extract and rose fruit extract showed androgen receptor binding inhibition




Licorice study.



Licorice study.


Rose hip/fruit

Licorice study.


“Effects of rose fruit extract on sebum secretion were evaluated by determining the inhibitory effect on TSR activity and androgen receptor binding. Rose fruit extract showed inhibitory effects on TSR activity and androgen receptor binding.”



Saw palmetto (serenoa repens)

Study: " The study participants applied a cream containing saw palmetto extract, sesame seeds, and argan oil twice daily for four weeks. . .  a significant reduction of sebum levels was noted—up to 42% in oily spots."



“In a study of 34 men and 28 women (18-48 years) topically applied SR [serenoa repens] extract in lotion and shampoo base for three months led to 35% increase in hair density and 67% increase in sebum reduction”



Sesame seed

First saw palmetto study.


Argan oil

First saw palmetto study.


Cedarwood oil

"The two extracts- cedarwood and poplar bud extract retained their activity at 0.5%. and effectively reduced the sebum levels."

“Cedar wood and elubiol application led to a significantly greater fall in the sebum reading at 6 weeks as compared to 3 weeks”




“After a couple of weeks, I noticed the chin was "dryer", indicative of less sebum being secreted than the other side . . . I can certainly assert that cedarwood alone helped that side of my chin to make less sebum."




 “topical in vivo application of a formulation containing 2% L-carnitine for 3 weeks significantly decreased the sebum secretion rate compared to the treatment with vehicle.”



Hydrolyzed wheat and soy protein

“Mean sebum readings charts showed Hydrolyzed Wheat Protein and Hydrolyzed Soy Protein exhibiting similar profiles versus Elubiol, with sebum readings decreasing with time, from 124-138 mu g/cm<2> at baseline to 68-81 mu g/cm<2> at week 12.”

“a similar trial in Australia on Australian teenagers . . . again showed Hydrolyzed Wheat Protein and Hydrolyzed Soy Protein exhibiting similar profiles to elubiol with sebum readings decreasing from 145-155 mu g/cm<2> at baseline to 117-124 mu g/cm<2> at week 12”



"We have demonstrated the inhibitory activity of [soy] isoflavone . . . suggesting that genistein and isoflavone would be used as an effective agent for androgenetic acne and for the inhibition of secretion of sebum by modifying androgen conversion"




"Transactivation of the MMTV-luciferase reporter plasmid by 0.1 nM DHT was inhibited in a concentration-dependent manner by both lavender oil and tea tree oil"




"About a month-6 weeks ago I started using about 1 drop or less of lavender essential oil in my nightly moisturiser (Neutrogena Essential Moisture) . . . Since I made this change (and I have pretty much kept everything else in my pretty simply routine the same) I have noticed a huge difference- I now don't get shiny skin at all, but it doesn't really feel dry.”


“I noticed that Lavender oil helped reduce the oiliness. But it also dries out your skin if you don't moisturize.”



Tea tree oil

Lavender study.


Seaweed extract (laminaria digitata)

“The findings taken together suggest that SOZC can significantly ameliorate symptoms of acne vulgaris, particularly in terms of reducing sebum production and populations of Propionibacterium acnes.”



Green apple rind extract

 “These results suggest that GAR-E can be applied in cosmetics to reduce facial pore size and sebum secretion.”




“Zinc displays 'in vitro' some antiandrogen activity through an inhibition of the 5 alpha-reductase activity”




“The results of the Japanese study demonstrated that the SER of the two groups was not significantly different at baseline, but the 2% niacinamide treated group demonstrated significantly lowered SER after 2 and 4 weeks of application. The results were somewhat different in the Caucasian study. After 6 weeks of treatment, the CSL was significantly reduced, but the SER was not significantly reduced.”



Pumpkin seed oil

“The oil fraction of pumpkin seed has been shown to inhibit 5 alpha-reductase. The mixture of delta 7-sterols has been shown to inhibit the binding of DHT to androgen receptors.”




Other ingredients that are purported to have an anti-androgenic or sebum-reducing effect but don’t have studies or significant anecdotal evidence to back them up (that I can find).


Topical: Thyme, sage, nettle, rosemary, pygeum.

Oral: Curcumin, resveratrol, magnesium, lithium.

#3339538 Vitamin D Has Cured Me Of Oily Skin And Acne

Posted by Jofo on 09 April 2013 - 01:28 AM

Just wanted to update and say that I have not seen a reduction in oil after taking 6,000IU of vitamin D3 for one month. I'm glad it worked for SebumSucks but I would be surprised if it worked for many other people.