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Member Since 17 Mar 2006
Offline Last Active Jul 13 2014 09:41 AM

#3328352 'recent' Advances In Acne Pathogenesis Information

Posted by sepsi on 20 February 2013 - 09:43 PM

And this forum is filled with people for whom it didn't work. And with people who chose not to use medicines that cause harm.


This forum is also filled with people who haven't made much progress with their acne in years. So not much of an argument.

#3328107 'recent' Advances In Acne Pathogenesis Information

Posted by sepsi on 20 February 2013 - 01:58 AM

Many things are anti inflammatory. So why apply something that causes harm?

BP never reduced my acne. And it increases redness and irritation. The forum is filled with people that say the same.


There's little evidence that BP, when used properly, causes any harm. And just like every other medicine out there, BP has both positive and negative effects. The art of medicine comes in choosing medicines that do more good than harm.


If BP reduced your acne, then you are among the minority. The other sections of this forum are filled with people who say that BP indeed has reduced their acne and skin redness. Not to mention tens and tens of clinical studies that show efficacy from BP.


Why use BP? Because at the moment it's one of the best anti-acne topicals. No 'natural ingredient' has similar demonstrated efficacy. Some antioxidants, like niacin and vitamin C derivates, show promise and might even turn out to be more effective than BP. That's for the future science to show. But it doesn't take away the fact that BP does work.

#3327859 'recent' Advances In Acne Pathogenesis Information

Posted by sepsi on 19 February 2013 - 01:45 AM

Also, because oxidized lipids in the skin are considered a culprit in acne formation and benzoyl peroxide is an oxidizer, I decided to look up some studies:


This one is about topical spearment reducing the harm from BP in mice:

http://www.ncbi.nlm....pubmed/11039327  "The result suggests that spearmint is an effective chemopreventive agent that may suppress BPO-induced cutaneous oxidative stress, toxicity and hyperproliferative effects in the skin of mice."


And this one is about retinoic acids reducing the harm from BP




I think it's a little simplistic to shun away from BP just because its oxidizing effect. Yes, inflammation is very bad for the skin and probably the very thing that triggers the acne formation process.
At the same time BP can reduce inflammation in the skin. It destroys the bacteria that escalate inflammation and also the cells that initiate the inflammatory process in the skin. 
Not to mention the fact that BP reduces acne and redness of the skin. Though, when used improperly, it can also damage the skin.
Also, if you want to reduce inflammation, why bother with spearmint oil or other herbal stuff? Straight vitamins B3, C and E are likely to be much more effective - not to mention easier to find in products.

#3321433 Green Tea/sea Salt Toner. Effective And Easy To Make

Posted by sepsi on 24 January 2013 - 09:35 PM

I noticed that somebody asked about how long this kind of toner stays good. A while back I looked at some research related to this. Unfortunately the catechins in green tea degrade quite rapidly. Under normal conditions you would find at home 50% were gone within the first 7 hours. Now, that's 50% starting from a lower concentration than what you get with so many teabags in a cup of water. Regardless, I wouldn't expect any tea to retain antioxidants for very long. You can extend the shelf-life somewhat by adding some vitamin C powder into the mix.

#3278886 Take Probiotics For How Long?

Posted by sepsi on 21 August 2012 - 07:31 AM

We still don't have enough reliable data to say much about probiotics. We know they work in some conditions, but the problem is that the benefits can be strain-specific, meaning that one strain works while other has no effect.

Many probiotics also cannot colonize the digestive system. They just pass through but have little long-term effect on the gut flora.

This is why I prefer to eat fermented foods daily. You'll often get a wider intake of probiotic strains, and you know you'll get live bacteria. With little regulation on supplements there's no way to say that those supplements have any viable bacteria.

#3278487 Homeopathy For Acne - Has It Worked For Anyone?

Posted by sepsi on 20 August 2012 - 02:23 AM

Homeopathy is to medicine what Deepak Chopra is to quantum physics. The fact is that most homeopathic "medicines" are diluted to the point where they have not even a single molecule of the active ingredient left. They are pure water (plus the contaminants that got in during the manufacturing process) infused into sugar pills.

And even if they would have active ingredients in them it wouldn't be much better. Because of the, quite frankly, ridiculous theory homeopathic "medicines" are based on. For example, a homeopathic drug for celiac disease would be manufactured like this: Take little bit of wheat and dilute it with this ratio, 1 part wheat and 100 parts water. Remember to shake vigorously. Then take 1 ml of that solution and mix it with 100 ml of water. Again shake. Repeat that dilution 30 to 200 times, always remembering to shake vigorously with each dilution, and you'll have your medicine.

It's based on sympathetic magic and that water supposedly has memory (makes you wonder what water remembers during all its passes through the toilet!).

Homeopathy has been studied a lot, there's your tax payer dollars at work. While poorer quality studies show mixed results, some even positive because of laws of statistics, higher quality studies show homeopathy is no better than placebo.

So yes it can work for some people, but that's because of placebo effect and not because of any healing property of the "medicine".

#3256566 Has Anyone Overcome Oily Skin Through Diet?

Posted by sepsi on 17 June 2012 - 11:38 PM

The best diet for reducing oily skin is one that keeps insulin and IGF-1 levels low. Both of those hormones boost the effect androgen hormones have on the skin, and they also stimulate the release of androgens from the lives. Androgens are the main hormones behind acne. There's not much you can do to affect androgen levels, therefore you best option is to reduce insulin and IGF-1 as much as possible. Full story here: http://www.acneeinst.../hormonal-acne/

In my books the best way to do that is by eating a balanced diet (such as 50/30/20; carbs/fat/protein) with emphasis on low GI carbs and monounsaturated fats. In most studies I've seen that sort of diet does better than low-fat diets in reducing insulin resistance and triglyceride levels.

To my knowledge it's high-amount of fats in the blood that cause insulin resistance and high insulin and blood sugar levels. This can happen as a result of eating a lot of fat OR carbs. Hence my preference of balanced diets. This one study (PFD) found that lot of free fatty acids in the blood (basically triglycerides prevents transfer of glucose to muscle cells and also reduces the amount of glucose the muscle cells burn)

Low carb diets can also work. They tend to reduce insulin, but you have to stick to them religiously for them to work. Eat a bit of carbs and your blood sugar levels are likely to go crazy.

I'm not sure your point because of how you worded it.  I was on fruititarian diet for 4 months.  I have horrible acne.  There is not even epimedeological data to support this diet.  Just a chiropractor who wrote a convincing book.

well because you are convinced it isn't for you then move along...

This is such a religious attitude. If you don't believe my chosen dogma then I'm not interested in talking to you. If you want people to take you seriously then please let evidence do the talking.

#3252902 How To Permanently Cure Your Acne!

Posted by sepsi on 06 June 2012 - 09:50 PM

Your claims are ridiculous do you honestly believe that acne is solely affected by genetics? My aunt and uncle both have acne but my cousins do not.Not any 4 of them.

Very nice straw-man argument. If you want to be taken seriously at least you should argue against what I actually said, not against a weak straw-man construction. Anyway, I never said acne was solely due to genetics. Just that genes predispose people to acne. The skin reacts more strongly to hormones (even at normal levels) and it has stronger than normal immune response against bacteria.

I hope you also realize that acne has not always existed. The first very few cases of acne were recorded in Ancient Greece. Next you are going to tell me that diseases are solely genetic and cannot be cured but only treated.

Keyword being recorded cases. There's no reason to believe acne did not exists prior to that time. Probably to much, much lesser extent than today due to our diet and lifestyle today.

By the way, if you do not believe any of these claims here is something. Go on an apple diet for three days eating only organic apples and filtered water. You must also have enemas done. See what happens.
I honestly understand where you are coming from, acne is a terrible condition and it ruins peoples lives. After many failures and attempts people become very skeptical of many things. But I atleast insist that you try he apple diet for 3 days.You will only see results on the 4th or 5th day.

And here you assume you are privy to some knowledge many veteran people in this board don't know. As I mentioned in the opening statements of my previous post, I was where you are 5 years ago. I did it all. Apple cleanses, 7 day water fasts, colon cleanses, liver flushes, urine therapy. I did all that. Many times.

Yes, apple diet may help. But only temporarily. And not because of any cleansing effect, but because of well-known and documented effect caloric restriction has on insulin resistance and systemic inflammation. Possibly also due to elimination of allergenic foods.

Isn`t there a quick fix? Although is healty and great to live by the rules you posted is hard and kind of controlling the way you live and as normal as it would be to eat the natural products you said it`s hard and expensive.

I've done all and everything posted by MysteryTutor. Sure it helps, at least a bit. But you don't have to go to the ridiculous extent he proposes. You can get the same results with a more moderate effort once you actually understand what and how you need to do.

#3252460 How To Permanently Cure Your Acne!

Posted by sepsi on 05 June 2012 - 09:56 PM

MysteryTutor, the reason the more veteran people give you hard time is that most of us been in the same place where you are now. I used to believe into that stuff 5 years ago, and you'll see it if you browse my older message.

I've since realized how ridiculous what you claim is. Let me just highlight a few gross mistakes and misunderstandings you made.

Acne is not a disease but a result. ( I will get into this later).

Pedantic and largely meaningless fluff statement. Depends on how you define disease.

Acne is correlated with genetics but only to some extent meaning genetics does not play a huge role.

This is demostrably and massively wrong. Having a 1st degree relative increases your risk of getting acne by 4 times. It's also been demonstrated in many studies that genes alter acne-prone skin so that it becomes more sensitive to androgen hormones. Conversion of testosterone to DHT in the skin is overactive in acne patients, thanks to genes. This causes excess sebum production, hyperkeratinization and excess growth of skin cells.

We also know the skin immune system in acne patients is reacting too strongly to bacteria and pathogens, and this creates the inflammation that triggers acne.

So genes affect ALL the pertinent factors in the acne formation process. This has been shown in many studies, and those evil pharma companies are even developing drugs that could do something about the problem.

Acne is not solely caused by sex, stress, hormones, oily skin, exercise, and fast food.

You got that one about 20% right. Sex has nothing to do with acne. Stress and hormones are among the most important factors in acne. Add inflammation (external and internal) to the mix and you've got the whole recipe.

Acne can be cured not just treated.

This is so wrong it's almost not even wrong. There's nothing we can do at the moment about the genetic disposition to acne we have. We can mitigate it with smart topical treatments, but that's all. The program you outlined does nothing to genes, which is the only way to cure acne.

I'm not saying that what you outlined wouldn't help. It would (especially if you skip the irrelevant cleanses and other nonsense), but all the relavant parts are already discussed here many times over.

This program is not a quick fix, and will be permanent.

Again, so wrong it's not even wrong.

The information I provide here may be a bit overwhelming but I advise you to bare with me, remember if you skip out on this you may still have acne and what is hurtful in reading this?

Not a fact, but marketing pitch for your post.

They will not advertise cures because if there are cures there will be no money in their pockets.)

Conspiracy mongering. False. And bad understanding of market economy. Do you really believe that if one company could develop a permanent cure for acne they would just hold it secret? Because they want to keep selling their cream in an intensly competitive market (and most likely go bankrupt doing it).

You don't see that if a company would develop a permanent cure that works that they would make billions overnight. Can you imagine how much they could charge for it? Most of us would gladly pay thousands of dollars for it. But no, instead they will hold it secret because they will make more money selling creams???

Acne is an internal problem not an external problem

50% correct. Acne is partly internal, but also partly external problem.

Anyway, most of the 'facts' that your theory stands on are false. So the whole thing falls apart like a house of cards.

As a closing statement, please don't take these comments as personal criticism or attack. I appreciate that you are trying to help people, and you should be credited for that.

It's just that ignorance combined with entusiasm is a dangerous combination. I know because I pretty much wasted 7 to 8 years of my life in that natural and alternative nonsense. Not saying all alt-med is bad, but that you have to be discerning and very skeptical of what's promoted there.

#3252113 How To Permanently Cure Your Acne!

Posted by sepsi on 05 June 2012 - 09:31 AM

I think one other reason people ignore this is that every few weeks somebody comes and posts the same thing. Acne is caused by toxin overload and other nonsense. This same story has been circulating for tens of years.

#3252022 Demodex Truly Is The Answer To Acne, Rosacea Etc.

Posted by sepsi on 05 June 2012 - 06:19 AM

It's not highly overlooked fact that demodex mites cause acne. The research on this topic is very scarce. The few studies I did see showed that acne patients may have higher rates of demodex than those with healthy skin. While that's interesting you can't make much out of it.

I can see a role for demodex in causing acne, though. Basically anything that irritates and causes inflammation in the skin can cause acne. But a lot of things have to happen (such as genetics and hormones) before demodex can cause problems.