I have been using Epiduo once before and It worked very good. I switched from the regimen to Epiduo and had no big problems whatsoever. I decided to quit the regimen because of the dryness, redness and all the time you'll spend on applying all the stuff to your face twice a day. I wanted a more simple routine and Epiduo gave me that.
After a couple of months on Epiduo I had to renew my prescription but It never happened because of laziness and I thought my acne was under control. I decided to replace the nightly Epiduo with the regimen once a day. After a couple of months my acne was back.
I got a new prescription and i'm back on Epiduo for a week now. Right now my skin is in the purging-state and my skin looks terrible. I'm looking forward to clear skin again I hope it works this time as well.
My current routine
Acne.org moisturizer + Jojoba Oil
I'll do some updates in this thread.