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Member Since 09 Aug 2013
Offline Last Active Apr 11 2015 06:00 AM

#3476003 Scarless Healing

Posted by cycloverid on 26 March 2015 - 02:46 PM

What about nanoparticles?





The nanoparticles with their siRNA cargoes were then tested by topically applying them to mice with either skin excisions or burns. In both cases, the wounds closed more than twice as fast as in untreated controls. "Not only did the cells move into the wounds faster, but they knew what to do when they got there," said Dr. Sharp. "We saw normal, well-orchestrated regeneration of tissue, including hair follicles and the skin's supportive collagen network."


They are moving to pig trials soon too:

"Dr. Sharp plans to start testing the therapy on pigs, whose skin closely resembles that of humans, within months."

#3475240 Acne Scars And Genetic Predisposition?

Posted by cycloverid on 19 March 2015 - 06:15 AM

Missamua,  you are speaking the TRUTH.  I'm all for natural living, but I have noticed the exact same thing with these health / holistic  super militant, vegan types who ALWAYS exaggerate their supposed health issues.  


What I think is happening is that

1) these people want to push an agenda and exaggerate to build a more convincing case for their world view

2) They attract a particular kind of person that is distrustful of the medical community at large


Theses are the same kinds of people who refuse to have their children be vaccinated because of unproven fears of health problems like Autism.  They are super militant and just attack anyone that asks them to back up their claims with cold, hard empirical evidence.  

   Yes.... those militant Vegans.... very dangerous for the world!!





Misinformation can be dangerous and really shouldn't be taken lightly. Look at the anti-vaccer movement, global warming denouncers or any religious movement, etc, etc, etc. We should always strive to apply science to everything we do and eliminate ignorance and misinformation.

#3467275 Scarless Healing

Posted by cycloverid on 09 January 2015 - 07:58 AM

Anyone who hasn't read this article yet should do so immediately:




It's an older story (2013), but this particular site just posted it now which prompted me to relay it to you.


It's well-written, a fun story to read, and has some amazing insights into what the future may hold for regeneration. The researcher, named Michael Levin, has been studying how electrical signals can be used to tell the body to start regenerating limbs and organs. So far he has only been able to get it to work on frogs, but the article states that his next project, which he is supposedly working on last year to current, is testing mammals - starting with mice. The initial test they are conducting is attempting to regenerate a mouse's digits completely after they have been cut off.

#3467114 Scarless Healing

Posted by cycloverid on 08 January 2015 - 02:52 AM

I've tried Co2 ablative and it caused some serious problems. I've also tried 4 fraxel restores, 4 repairs, and 4 rounds of subcision. 


I'm wary of try-it-yourself solutions as I could just make things worse. Also, I'm not sure they're more effective than what I listed above.

#3460087 Scarless Healing

Posted by cycloverid on 16 November 2014 - 07:25 AM

Actually it is injectable..

Atrophic scar equals missing flesh

Just inject something like dextran hydrogel and be done with it

Why do we need to excise something if its already sunken?

Just my opinion btw


Your opinion doesn't matter in this case because the literature is out there and it simply doesn't work the way you describe.

#3450330 Scarless Healing

Posted by cycloverid on 03 September 2014 - 01:48 AM

Here is another recent wound healing article:



This one is interesting because it allegedly treats the following (listed in the link):

  • burn wounds,
  • split-thickness skin graft donor site wounds,
  • aesthetic treatment wounds (caused e.g. by dermabrasia ablative laser, deep chemical peel),
  • radiation wounds,
  • skin lesions caused by toxic epidermal necrolysis and
  • skin lesions caused by genetic diseases such as epidermolysis bullosa.

So it looks like they're maybe aiming for post-laser, post-dermabrasion application which is somewhat exciting.


This article is also interesting if you're into general regenerative medicine:


#3446623 Scarless Healing

Posted by cycloverid on 11 August 2014 - 04:41 AM

This particular discovery was in the news a few months ago, but here's a new article on it: 



It's called LLLT low-level light therapy (also referred to as photobiomodulation - PBM). They were able to get dentin in teeth to regrow, and they are talking about it possibly working on the skin.


Here's the pertinent quotation: 

"The research promises a broad range of clinical applications in restorative dentistry and regenerative medicine, including wound healing and bone growth. And it hints at dramatic changes for dentistry and other disciplines."


Just thought I'd share some promising news since there's no word about Dextran Hydrogel.

#3442136 Scarless Healing

Posted by cycloverid on 18 July 2014 - 04:00 PM

#3430266 Scarless Healing

Posted by cycloverid on 05 May 2014 - 07:51 PM


#3423270 Scarless Healing

Posted by cycloverid on 30 March 2014 - 01:44 AM

This post is endless, isn't it?


... Either then or when we all get sick of waiting. 


Well, we have received bread crumbs of news, so it's totally feasible that the large animal trials really will wrap up in a few months. This will be a big day for Dextran Hydrogel. Don't give up yet. We need a large community working together to expedite getting this into doctors hands.

#3423178 Scarless Healing

Posted by cycloverid on 29 March 2014 - 12:58 PM

So the large animal trials should be done by summer. 


Back in November they said they'd be done in 3 to 6 weeks. Where did you hear that they'd be done in the summer?

>Lapis that was in 2010 and it was a future sounding statement. It is also a statement by authority, which is a highly unreliable way to judge any information, it is open to human biases. However, since then there have been two or three testable scientific documents that show results. We have the hydrogel which beat the control, and got compete regeneration and is advancing. We have the msc whartons jelly which regenerated appendages which is not advancing yet, as far as I know.


Seems unlikely to me that all her work is basically going to be proven to be pointless just because the hydrogel has come along.



From the Facebook page:

 Hi Bart sorry for the late reply. Gemstone Therapeutics (the investors) have stated the trials are midway and they hope to have results by the summer.

#3421394 Scarless Healing

Posted by cycloverid on 19 March 2014 - 10:47 PM

This argument seems utterly pointless. Seabs is right when discussing to the scientific data, which is incomplete in regards to answering the question of whether or not it will work for *humans*. We must wait for that. We don't know the answer yet...

#3409713 Scarless Healing

Posted by cycloverid on 22 January 2014 - 01:30 PM

From wikipedia:

Scarless wound healing is a concept based on the healing or repair of the skin (or other tissue/organs) after injury with the aim of healing with subjectively and relatively less scar tissue than normally expected. Scarless healing is sometimes mixed up with the concept of scar free healing, which is wound healing which results in absolutely no scar (free of scarring). However they are both two different concepts.


I think this has been discussed already, but it's happening again... I think it's still really confusing that posters are still using the phrase "scarless healing" when that's not really what anyone wants. Scar free healing is what this thread *should* be about, as per dextran hydrogel.


I'm afraid that scarless healing, being a *subjective* measurement of "less scar tissue", is highly likely to just be a waste of time to get excited about. I'm sure all of those silicone gel and derivative treatments out there could claim to be scarless healing.


Most scar treatments nowadays seem to frequently yield a placebo result than something objective and concrete. The only thing I'm actually excited about anymore is something that truly promises objective results, i.e. scar free healing.