Jump to content


Member Since 04 Mar 2013
Offline Last Active Sep 20 2014 03:29 PM

#3451854 Understand & Cure Acne- The Skin Is Used For Excretion!

Posted by Quetzlcoatl on 13 September 2014 - 08:01 AM

This is mostly voodoo. There is a lot of science behind and, and it's becoming apparent that the cause is almost always immune dysfunction in some form.


what if my blood is great and i have no inflammation and have good immunity?


Then you don't have acne

#3450742 Y Does It Take 666 Million Years To Fade Redmarks ?

Posted by Quetzlcoatl on 05 September 2014 - 05:22 PM

Diet looks great.  I'm still on accutane so the reddishness is still here, but I have no doubt it will go away. I do basically paleo but I consume a lot of fermented dairy. I recommend yogurt as it is highly insulinogenic and will increase the turnover rate of your skin.

Vitamin D can potentially help as well, as can mild sun damage/tanning.

Many vitamins take ages to accumulate (like vitamin D), so keep going strong with the diet and you may see improvement with time.

#3450051 Age Blocker

Posted by Quetzlcoatl on 01 September 2014 - 10:49 AM

So I looked into this a little bit and I think it would be worth it to clarify what benfotiamine actually does.


Benfotiamine is a synthetic relative of thiamine. It's been modified to be more lipophilic, which allows for greater biodistribution in tissues. Thiamine, on the other hand, is entirely water soluble, which means that overdosing on it will not really lead to much of a therapeutic benefit as it will be cleared from the blood very quickly. This is the only difference between the two compounds; once thiamine/benfotiamine is inside the cell, the mechanism of action is the same.


The mechanism of action is basically increasing sugar metabolism, which raises the threshold for glucose toxicity (glucose toxicity is the state in which the glucose concentration of a media/cell is high enough for proteins to become randomly glycosylated without the need for enzymes. Glucose toxicity directly results in the formation of AGEs).


What does this mean? It means that if you are on benfotiamine, it could allow you to eat more sugar without experiencing the negative effects. However, it also means that benfotiamine will not remove AGEs that are already formed. There is no known compound that is able to cleave AGEs at any therapeutic level, but a lot of research is currently being done in this area.


That being said, the body naturally metabolizes and excretes AGEs over time. If one were to take benfotiamine for a long period of time to limit the formation of new AGEs, eventually one might see a decrease in total tissue AGEs. This does carry an unknown risk with it, though, as benfotiamine is not thiamine, and could cause unforeseen complications when taken for an extended period of time. This is my conjecture, and I have no evidence for negative side effects, but I think it's worth it to caution against the unknown.


A small final point I would have is that using benfotiamine as an excuse to consume extra sugars would result in no net benefit. If one were to aim to reduce their tissue AGEs, they would need to reduce their sugar intake/glycemic load of foods and take benfotiamine at the same time.

#3449249 1500 Negative Posts About Accutane

Posted by Quetzlcoatl on 27 August 2014 - 12:01 PM

Side effects arise and become permanent for a few reasons. If you have a pre-existing autoimmune condition or a family history of such, your risk is probably much higher. If you have mutations in the pathway that metabolizes the drug, your risk is much higher. If you have poor nutrition, your risk is much higher.

Preexisting conditions and family history are easy to decipher. Nutrition is a bit harder, but it can be improved and then excluded as a risk factor. Genetics are the most difficult to deal with, but are also the rarest.

It's important to not that the incidence of side effects is not cumulative. Certain people are at risk for many side effects, whole others are at risk for very few. You need to with that risk for yourself; for most people, it works out, and most people don't give a single damn about recognizing any of the things I listed.

#3447787 Overdosing On Vitamin A, Good Idea Or Nah

Posted by Quetzlcoatl on 18 August 2014 - 07:15 AM

The rate limiting step is the enzyme that converts vitamin A into its derivatives. Overdosing on A will simply allow the vitamin to accumulate in your tissues and possibly lead to some unwanted side effects. Accutane gets around the enzyme issue by being a downstream non rate-limiting metabolite.

There is no such thing as accutane without the side effects.

#3444706 If Acne Was Caused By Diet Why Would It Only Start At Puberty?

Posted by Quetzlcoatl on 31 July 2014 - 07:52 PM

It's more than diet, though. It's also environment, immune system development, and epigenetic inheritance. I think one should be careful of suggesting a single causal factor for the myriad types of acne.

#3444419 Acne Doesn't Signal Illness

Posted by Quetzlcoatl on 30 July 2014 - 04:10 PM

Acne can certainly be an indicator of illness. Chloracne, for example. But even normal acne is present for a reason. At the simplest baseline, having acne means that something is not functioning as it should. In most cases, it's immune system related (though the causes of immune dysfunction are many). Does this mean we have an illness or a flaw? Certainly at least the latter. Can it be fixed? Probably. Is it in our genes? Ultimately, everything is.

#3443843 If Acne Was Caused By Diet Why Would It Only Start At Puberty?

Posted by Quetzlcoatl on 27 July 2014 - 07:12 PM

These are studies not facts. Not every study is right actually many are absurdly flawed (vaccines cause autism ect.). 


I think what you're trying to say is that acne is really an immune system issue. If that were the case wouldn't that spread over into other aspects of the immune system? Wouldn't acne patients be sick all the time if they were so immune impaired. 


I have had acne since I was 12 which warranted Accutane at 17 and have always had a normal immune system. Even as a now ventilator dependent quadriplegic I rarely ever get sick with UTI's or upper respitory infections. Why is that? 


Nothing is really a fact, but we have occam's razor for that. Acne has nothing to do with having a 'good' or 'bad' immune system. It has to do with having parts of your immune system dysregulated. And yes, sometimes you will see bleedover effects - people with acne are more likely to be diagnosed with celiac disease, IBD, and dandruff, for example. These same people might have perfectly aligned immune responses to unrelated threats - maybe they have shitty skin, but never catch a cold. Is their immune system good or bad? Neither, really. They just never learned to tolerate a particular microbe that lives on their skin because somewhere along the line, something interfered with the development of a normal immune response to that one microbe.

#3443833 If Acne Was Caused By Diet Why Would It Only Start At Puberty?

Posted by Quetzlcoatl on 27 July 2014 - 06:46 PM


.. Also if acne was an immunological condition like some of you are saying why don't they just treat it with steroids? They don't, because it's not. 


no derm considers acne an "inflammatory disease" it's considered hormonal and tends to be hereditary. 



Meh I tried. Believe whatever you want. 


You could try reading this article, since I know you will not take my word for it: http://www.medscape....warticle/448506


Dermatologists today were educated with principles decades now outdated. Recent research shows that acne is an outcome of immune dysfunction:


Isotretinoin normalizes TLR2-mediated immune response: http://www.nature.co...id2012111a.html


Correlation between certain immune factors and acne severity: http://eng.med.wanfa...e=zhpf201102017


Microcomedogenesis driven by immune factors: http://europepmc.org...ct/MED/23986176



The information our medical practitioners have is from time to time outdated.

#3443806 If Acne Was Caused By Diet Why Would It Only Start At Puberty?

Posted by Quetzlcoatl on 27 July 2014 - 05:01 PM

wow i actually wanted to ask the same exact question like a day ago! :0
what is in our bodies before puberty that allows it wont be inflammed then?
why do other ppl dont even get no acne during puberty?
the same goes with allergies and intolerances that are popular here, dont u have those from when ur born not appearing some random time at ur life? 
when i was small could eat dairy, grains etc just fine somehow..only had somekinda alergy from oringes (but not allways either?), would break out everywhere, but those were not acne nd it wasnt just on face (like usually it is first and only place where acne starts)
now ill do diff crazy health cleanses and do clean diets, supplemetns etc etc and still break out like its nothing. max few days without new breakouts. but then again i was on bad diet and also will get good skin days. diet improves skin quality a bit i think but it seems so freaking useless for acne..


It's the immune system. At some point, the immune systems of most people who have acne gets messed up. There are lots of ways to accomplish this. And the immune system is so modular that it is conceivable that these problems can just pop up out of seemingly nowhere (though I doubt this is the case with acne). 


I think it's useful to catch a glimpse of the broader picture here. Acne starts at puberty for many people - but not for all people. Let us assume that there is something about puberty that allows for acne to form, given the right conditions (a fair assumption I think). For those people who begin to get acne right as they hit puberty, it follows from the model I describe that these people were suffering from pre-existing immunological conditions - an immune response that was always there, but could not manifest itself until the crucial puberty factor came into play. 


Now the other people - those who get acne at some later age, be it 14, 15,18, or 25. These people already have the puberty factor. So when these people get acne, the model would predict that the cause is a 'random incidence', by which I mean an immunological change that occurs, as you describe, seemingly randomly. If we consider for a moment that these 'random incidents' are actually randomly happening, the model would predict that most acne sufferers begin to get it around puberty, because puberty would essentially be revealing 12 years of random immunological incident. So you see, it does make sense.

Exactly. People for the most part when they're allergic to something have the allergy rear during childhood - not adolescence. I think it's pretty clear for those of us with good common sense that acne isn't a good allergy. 


I could be be wrong but I think a lot if the theories coming from this section of the forums are propelled by pseudo science. 


Acne is certainly not an IgE-driven allergy such as a peanut or egg allergy seen in childhood. But there are many other antibodies involved in immunity, and whole sections of the immune system that don't bother to use antibodies. There are even other types of hypersensitivity - types 1 through 4. It is conceivable that acne, which is without question a physical manifestation of an immune response, could in some cases be propagated by food antigens, even using one of our existing definitions of hypersensitivity.

#3443535 My Way Too Clear Skin.

Posted by Quetzlcoatl on 26 July 2014 - 01:56 PM

Naturopaths, I think, are useful for diagnoses. The tests they can order are extremely extensive and can tell you all about the state of your vitamin and mineral levels, gut flora, and immune responses. However, I am not so sure that naturopaths are particularly useful when it comes to remedies. Other than following a paleo-esque diet and taking a good multivitamin (and maybe vit D), there isn't a lot a naturopath can offer - and none of these solutions require a naturopath. I would be wary of any herbs prescribed, too, as some can be dangerous.

#3428497 Vegan Diet For Acne?

Posted by Quetzlcoatl on 25 April 2014 - 12:22 AM

I am quite against vegan diets. Animal products have so many nutrients, and the macromolecular composition is much safer than plant products (fat is the safest macromolecule). While it's true that plants have a far superior antioxidant profile, they also have a lot of dangerous proteins that are specifically produce to interfere with our digestion, from taste to inhibition of nutrient absorption. They are also almost universally higher in carbohydrates, which leads to more oxidative damage.


There are plenty of arguments from evolution that also do not favor a vegan diet, but I won't begin to mention those. What is worth mentioning, however, is that a vegan diet is essentially impossible without supplementation due to a lack of vitamin B12 in plants. Several vitamins are also only fat-soluble, which makes it a little more difficult to get the most out of your meals, especially when your digestive enzymes are being inhibited by plant proteins commonly found in things like nuts, seeds, and legumes.


I would say, though, that plants have a necessary role in any diet. They are incredibly rich in many nutrients, and the antioxidants help to dampen the negative consequences of eating meat (these consequences are mostly present in modern meats because of how the animals are fed and processed. Feed crops absorb toxins from the environment (including pesticides and heavy metals) and are fed in massive quantities to the animals, which accumulate the toxins in addition to some of their own (vaccinations and antibiotics). Humans then eat the meat, and accumulate these toxins over many decades. This is not a detriment of the meat itself, but rather a consequence of being an apex predator in polluted land and sea).


A vegan diet for general health would probably lead to malnourishment unless one makes concessions, such as eating large quantities of legumes (take a careful look at this picture of a soybean; those are not hairs on the pods, but razor sharp spikes. Walk through a soybean field around the time of harvest and your legs will bleed: http://thenaturalfar...es/SoyBeans.jpg), excessive polyunsaturated vegetable oils (easily oxidized, quite bad for you), or egregious quantities of yeast (gotta get those B vitamins). For acne, I can't see it helping much either. In fact, because acne is a disease driven by a dysregulated immune system, a vegan diet might cause more damage in certain people because of all the antigenic foods (wheat, soy, peanuts, etc). If someone is getting acne because they are deficient in a particular vitamin, a vegan diet *could* help, but so too could any diet with that has plants as a part of it. Steamed meats are incredibly safe to eat; think about it - how many people have made the observation that their breakouts may be tied to unseasoned chicken, or white fish? And how many have made the observation that it's a plant food - citrus, strawberries, wheat, nightshades, nuts, soy, etc? The balance is shifted in favor of animal products.


But of course, as with all things, moderation; if all you eat is salami, you'll have a much higher chance of ending up with hypertension and colon cancer.

#3426960 Please Help, Any Suggestions

Posted by Quetzlcoatl on 18 April 2014 - 01:43 AM

There are a lot of things you could do. You could take an IgG sensitivity test to see if you're sensitive to particular foods. You could also do vitamin testing to see if anything there needs correcting. Lots of oil, red marks, and a few spots here and there sounds like it could be related to vitamin D, or perhaps another vitamin imbalance.


It seems like your diet is mostly carbohydrates, which are known to aggravate acne. You could try switching out some of the starches for whole cuts of fish and chicken. I would also try to add in some good fats like coconut oil and ghee. Fat is the safest macromolecule. In general it's best to get most of your calories from fat, and then have relatively equal portions of protein and carbohydrate.


I would stay away from most of the topical stuff. Acne is an internal condition. If all of the above fails you, I would recommend a low dose of isotretinoin, no more than 10mg/d.

#3426080 Anyone Solved Acne From A Dermatologist?

Posted by Quetzlcoatl on 13 April 2014 - 03:51 PM

The dermatologist will not tell you anything you can't find online. Here's the advice I will give, and if it doesn't work, then go see the dermatologist.


Adhere strictly to a paleo diet with plenty of vegetables and fish (potatoes don't count) and bone broth meat and vegetable soups. Wash your face only with a mild cleanser and water, once a day. Get sleep and sunshine. Take 5000iu vitamin D3. Do this for at least 2 weeks. While 2 weeks is not long enough to get clear, you will probably start seeing improvement by then. If you see no improvement, go to the derm and ask if they think a low dose (10mg) isotretinoin course is reasonable.


If you really want to solve this problem, continue the paleo diet while on the isotretinoin course, keep taking the vitamin D3, and keep getting sleep and sunlight. I 98% guarantee that your acne will be gone in 3 months of this plan.


Don't use antibiotics. They will cause more damage in the long term. Don't bother with topical treatments. Acne is an internal problem.

#3425961 Please Help With Diet

Posted by Quetzlcoatl on 13 April 2014 - 02:16 AM

Sounds like you could have a few different things going on. I would start by switching out all legumes - chickpeas, mung beans, dosa, lentils, etc - for non-processed meats. I would recommend chicken and fish.


Soup is a wonderful healing food. If you use a whole chicken to make bone broth and add in some rice, vegetables, and herbs, you'll have a complete and incredibly nutritious meal.


I would also recommend that you increase your fat intake. Fat is the safest macromolecule, especially if it's saturated. Coconut oil and ghee are the best. If you eat some fat with your vegetables, you'll get more nutrition out of them.