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Member Since 15 Apr 2012
Offline Last Active Oct 25 2014 10:41 AM

#3315017 Gut Flora And Leaky Gut. After 5 Years I Finally Found The Root Cause And I...

Posted by BSider on 02 January 2013 - 12:05 AM

Again, I do think there is potentially something to aspects of the gut diet, based on the evidence that I've been looking at (no thanks to you linking the same thing over and over). However, because these studies are not in humans, you cannot conclusively state that probiotics will cure humans of intolerances.

I haven't looked to see if there are any studies to see if probiotics affect food intolerances, but there are quite a few studies on how probiotics and prebiotics affect intestinal permeability.  Below are some of the ones I've found that were performed with humans or mice:
  • Lactobacillus casei Shirota (probiotic) at 3x6.5Billion didn’t seem to improve leaky gut, but maybe a higher dosage would help.  Link
  • Probiotics seemed to improve leaky gut in mice.  Link
  • 2 weeks of 16g of prebiotics (Orafti Synergy1) helped glucose regulation, lowered hunger and increased activity of gut bacteria.  Note: Jarrows InulinFoS contains Orafti Synergy1  Link
  • 2 weeks of 6g/day of prebiotics didn’t help improve intestinal permeability in burn victims.  These results were explained with the lower gut bacteria mostly benefit from prebiotics, not the upper gut bacteria. Link
  • 1 week of probiotic/prebiotic didn’t improve gut barrier function but increased beneficial bacteria in upper gut.  Link
  • Probiotic/prebiotic (synergy1) helped improve inflammation markers. Link
  • Probiotic Lacto bacteria (200 M) for 8 weeks increased pH and decreased pathological bacteria to 1/10 the previous level. Link
  • Probiotic in yogurt (10e12 cfu) in Egyptian children significantly decreased intestinal permeability (42 days).  Link
  • Probiotic fermented milk for 4 weeks (Streptococcus thermophilus, Lactobacillus bulgaricus, Lactobacillus acidophilus and Bifidobacterium Longum) significantly improved mucosal barrier function. Link
  • Grapeseed extract may help intestinal permeability.  Link
  • Inulin pasta significantly decreased intestinal permeability and significantly increased zonulin over two 5-week study periods (unsure about exact% from abstract) Link
  • High fat diet increased intestinal permeability in mice.  Link
  • Probiotic supplementation over 14 weeks helped decrease gut permeability markers  (> 20%) in trained men.  Link

Overall, studies with longer duration and higher probiotic/prebiotic amounts reported better results with improving intestinal permeability.