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Member Since 19 Nov 2011
Offline Last Active Oct 23 2014 04:51 AM

#3421214 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 19 March 2014 - 04:04 AM

** The regimen: 
wake sunrise
eat pot: 1x chicken breast, 1.5-2 cups rice, 1-2 handfuls small shrimp, bottled water. take with .5-1g UDCA (for liver damage) and thumbnail (dead nail, not cuticle) of Blue Ice. Stir Blue Ice well into pot, take UDCA separately. Reuse same pot and spoon to avoid dishes.
afternoon: eat pot (same)
pre-sundown (optional): pot 1 cup plain rice
blue blocker glasses sundown
start winding down.
blindfold and bed early enough to wake without alarm
This gets me a baseline with no cyclicality. Last pieces were figuring out bottled water and taking small dose Blue Ice with meals to dilute. 
Optimized for those with severe fat malabsorption and IBS/IBD. But it doesn't seem anyone else here is still suffering from gastro.
Agree that Cannabis is wave of the future. Smoke em if you got em. Drink em if you're Heisenberg. 

#3395303 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 17 November 2013 - 08:08 AM

no joint pain, no. 
Agreed Nick Ryan, except that it does not logically follow that an epigenetic change induced by environment is therefore reversible by environment. Humpty Dumpty, bullet to the head, etc. 
Dubya B, you are on point today. Brainfog clearing?
Judging by your second post, yes, undoubtedly. 
"Something I find very interesting is the few recoveries resulting from water fasting. It has been shown in vitro, that if a cell is starved for long enough, it will begin shedding epigenetic tags and makes its way back towards pluripotency."
Damn, but...
" I'm not sure if this has anything to do with the fasting recoveries since it would be difficult to accomplish the level of "starvation" as in the in-vitro experiments while still living, but it is something to think about.
I have completed a 7 day water fast, and a couple other sufferers have gone 21 and 28 days without remission of symptoms, so it is not a sure thing."
Ouch. Mega ouch. 
Still. "This kind comes out only by fasting and prayer." Something to think about.
"She eats organic, makes a living from organic farming, and basically lives organic, but still suffers severe side effects. ...It only helps so much. I will try to get her on this board if I get a chance to speak with her again soon."
I'm fascinated by such cases. I wonder how much vegetables and fat she eats. One million percent organic of either would slay me. 
Anonyy is probably wonderful to talk to in person. Disorganized posters typically are lively, engaging conversationalists. But not useful on forums. 
Ouch, MovingOn. I continue to do quite well on my regimen. Just need the blue blockers to cut the fluorescent light and I'll be 100%. Standing desks help quite a bit with nap adherence and productivity. 
Can you summarize Accutaneispoisons recommendations, TaneAbomination? Ah, Rick Simpson oil, yes legit. 
"Excerpt: " The following adverse effects have been reported to persist, even after discontinuing therapy, suggesting persistent (or perhaps slowly-reversing) gene expression changes and epigenetic effects: alopecia, arthralgias, ocular abnormalities, inflammatory bowel disease, keloids, osteopenia, hyperlipidemia, erectile dysfunction, and psychiatric disturbances. Isotretinoin is postulated to have complex effects on the brain and central nervous system.""

#3394161 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 11 November 2013 - 08:23 PM

I managed to eliminate the cyclicality and fragility!


First I got a healthy, controlled baseline: rice and lean shrimp only. Then I introduced new things. First I tried free range lean chicken breast. Worked fine. Then same chicken type but drumsticks, and yogurt. Gradually proceeded to meltdown. Cannot tolerate fat. Dialed back to lowfat chicken breast, rice and shrimp. Worked again. 


Adding the chicken breast makes the diet more stable:

1.I can overeat without abnormal consequences.

2. The abnormal compulsion to overeat is gone

3. I have more energy and better mood


I theorize this is because the chicken breast gives me sufficient protein, and a little bit of very diluted fat. 


I now know for sure that fat quantity alone is a trigger. This confirms the general trend of the dirtier data I accumulated in the past.


I'm now able to make zero-variance clean experiments, because simply staying healthy and on regimen is no longer a struggle. Even when you factor in life/job interruptions. 


Regimen summary:

Eat only

1. true free range lean chicken breast (expensive)

2. Lean white-tail shrimp (moderately expensive)

3. Glutinous rice gruel (very cheap)


All ad libitum, minimum 150g shrimp/d. 



1. Blue Ice CLO / Butter Oil blend

2. Udca ~1-3g /d

3. Source Naturals Essential enzymes 2x per meal

4. Symbiotics Colostrum ~1/8 scoop per meal

5. Cycled topical testosterone cream

6. Topical ACV, tea tree oil (morning) and benzoyle peroxide 10% (night)



1. Aim to nap every 3 hours for 20 minutes

2. Match light exposure to sunrise, sunset

3. Match meals to sun

#3389648 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 20 October 2013 - 12:39 AM

Still here, still healthy, still working full time, still improving. 


Eating only whiteleg shrimp and white rice and water. Moderate portion control is sufficient. 


Try to avoid eating after sundown. Avoid protein late at night. Take 1.5g/d UDCA +. Two source naturals essential enzymes pills with rice. Also take UDCA and colostrum powder with rice. Cycling testosterone cream. 


Fixed weekly fatigue cycle by not sharing bed with gf on weekend visits. Now at 7d/week uptime. 


Blue Ice Fermented Cod Liver OIl / Butter Oil blend in mornings. 


Limit light exposure after sundown. Get light exposure at sunrise. 


That's it. Regimen is now pretty robust and fault tolerant. Model accurately predicts tomorrow's health. 


KPI tracking switched from dumps to daily uptime, because IBS no longer central. 

#3383336 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 18 September 2013 - 03:07 AM

Still taking Blue Ice, still seeing full benefits. 
Switched from yogurt to true free range chicken and rice. With portion control, am normal. Portion control no longer an extreme hardship. Just have to eat reasonably. 

#3380217 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 03 September 2013 - 06:34 PM

Have all those genes. Have the MTHFR mutations as well. Will try methylfolate.


Very bad reaction when changed shrimp brands to vietnamese tiger prawns. Back on whiteleg shrimp and doing fine. Continuing career progression, life progression. 

#3378510 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 28 August 2013 - 07:25 AM

Maybe you should sashimmy off the stage instead. 


Watch the additives in dried seaweed and the bacteria in sushi. I find I'm sensitive to both, probably. Or maybe with the sushi it's fat, can't tell. 


Tons of shrimp makes me a happy camper. 

#3375512 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 17 August 2013 - 01:47 AM

Your absence will be as welcome as your reading comprehension is absent. 


"a particular supplement containing potentially toxic doses of vitamin A are being repeatedly promoted as innocuous"


Nowhere have I said that Blue Ice is innocuous. In fact, I have warned that taking a high dose is rather uncomfortable.


I have said:

1. It is DIFFERENT THAN regular cod liver oil. 

2. It is, by hard repeated experimental evidence, extremely beneficial FOR ME. 

3. It MAY BE extremely beneficial for others here.


I have further encouraged someone else here to test a LOW DOSE, ONE TIME. Preferably, NOT someone with a previous or suspected history of reactivity to vitamin A. 


Now, please calm down and exit the building. 

#3375485 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 16 August 2013 - 10:25 PM

So? Academic journals are funded directly and indirectly by pharmaceutical giants. 
Sponsorship != affiliate link.
You might as well say we can't link to the Indy 500 because they have sponsors. Or Youtube videos, because they have ads. Or Google, because it has ads. 
Unable to argue the substance, a petty fellow resorts to rules lawyering, in an attempt to shut down speech he does not like. 

#3374990 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 15 August 2013 - 08:31 AM

I agree. This thread is no longer useful to me, and I will be leaving. Linking is fundamental to providing value on the internet. Congrats to dubya for finally finding a way to destroy the thread. 


If you would like to continue what this community once was, PM me. I'll set up our own forum. 


All decisions occupy a location on a spectrum from brilliant to abysmally stupid. This moderation decision is somewhere on that spectrum.


Clearly this is a place for empty whingeing and specious pdfs, not concrete solutions. 

#3373940 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 12 August 2013 - 06:06 AM

I am at health lvl 6, Nick. Thanks. 
I don't think it's valid to say that your cod liver test indicates cod liver oil will not be powerfully beneficial for everyone. 
While I have not tried plain cod liver oil, I have tried fish oil and krill oil with no effect. This mirrors your experience - omegas alone don't do anything.
When I say I am using cod liver oil, that is actually shorthand for Blue Ice fermented cod liver oil and grassfed butter oil blend. The processing method used by that brand, and the addition of grassfed butter oil (vitamin K2), make it a completely different supplement. 
I look forward to seeing whether my results are reproducible for others here. We will know when someone buys and tries one of the recommended cod/butter oil blends here: *Moderator edit, URL removed – please read the board rules*
That site has a full explanation as to why plain cod liver oil != what I am taking.

#3371787 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 04 August 2013 - 11:16 AM

Upping the ante for uselessness, Camaroz now cites the gruesome extraction process for natural UDCA, as some sort of indictment of synthetic UDCA. By similar logic, nobody should wear synthetic diamonds because the natural diamond trade causes war in Africa. 


The skull in my avatar represents the pitiless reality of biological law and physical pain. It is indeed an emblem of fear - but intended as a reminder to myself, not as a way to impress others. It is what *I* fear, above all else. And I have earned the right to that fear, by countless long, slow, unbearable, hopeless hours of torment. 


The amusing thing about your effeminate narcissism is that when called on it, you proved the point by having a meltdown and getting yourself banned. Then you reconfirmed it by working even harder to win back the approval of the group and take down your perceived enemy. It's undignified and unbecoming, but a narcissist shunned will go to any lengths to regain the acceptance of the group.


Even if, as in this case, it means creating unnecessary work for the (likely unpaid) moderators of a large and charitable forum.

#3371667 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 03 August 2013 - 11:37 PM

# of cases of cancer attributable to UDCA: Zero. 
# of adverse reaction reports for UDCA in HK, where it is OTC: Zero. 
Value of the umpteenth iteration of Camaroz's contributions to this forum: Zero. 

#3370508 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 31 July 2013 - 12:21 AM

Natto is dairy free. Butter oil obviously is dairy.
Just figured out the cause of the last two episodes. It wasn't a refrigeration fuckup. It was a different brand of shrimp. 
Sometimes my usual frozen source runs out, so I found a stopgap - chilled shrimp at another grocery store. First episode I wasn't sure of the cause, yellow listed the chilled shrimp and redlisted sloppiness on milk refrigeration for yogurt prep. Second episode hit despite perfect yogurt prep. Both episodes 24 hours after eating the chilled shrimp.
The second time, I'd smell tested the chilled shrimp, cooked immediately, consumed within one day. Didn't matter. 
I'll check the label and see if they're adding sodium triphosphate or something. But I suspect it's just a quality issue. It's "pre-frozen" and from china, and tastes mushy compared to my usual zesty perfect flavorful frozen source. 
This is another confirmation of previous observations on the importance of meat quality. Organic free range chicken vs. regular makes the difference between IBS attack and healthy for me. Apparently a lot of the meat out there is quite poor quality, even at respectable supermarkets. 
Damn this hypersensitivity. I'd say that mercifully it's over, and mercifully it wasn't anywhere near as bad as it's been in the past, but there was still nothing merciful about it. 
Just goes to show the importance of experimental hygeine and journaling. This could've kept happening if I hadn't been carefully tracking. It would've been easy to blame on the attendant mild overeating and poor sleep, but those were merely symptoms, not the cause. 
Lesson learned. If shrimp is mushy and bland, do not eat. Should be frozen until cooked, then eaten immediately, zesty snap crunch, nothing added. 

#3369243 Repairing the long-term damage from Accutane

Posted by JosephBuchignani on 26 July 2013 - 01:02 AM

Of course you're moving on. One doesn't leave a dead mouse in the trap to stink up the place. 
I have no problem with those suffering from severe male sides obsessively focusing on androgen receptors. I think they might benefit from a more holistic approach, but I fully acknowledge theirs is a hard problem which I am very glad I do not have to solve. So I am content to leave them to it, figuring that they know best. And I am happy to take what is cross-applicable from their findings.
Meanwhile, I obsessively focus on the gut. But I've learned not to insist that my gut specific solutions, such as extreme elimination diet, are universally required. 
As the Fox0 paper makes clear, Accutane can do lots of different things, and what it does is unpredictable and selective for each individual case. Androgen receptors are only one of several things that can go wrong. So while it MIGHT be justifiable to warn away androgen cripples from green tea, it is ludicrous to insist that the general accutainted population must do so. 
The only real thing that exists for this community is cure case studies. Everything else is speculation. I am delivering; you are not. 
It is absurd to suggest that I am not dealing with an Accutane side effect, since it is IBD, not chemical castration, that was the side effect that forced Roche to pull it off the market. You consistently oppose things that work very well, and (as far as I know) none of your dire predictions have ever materialized. That is why people try my ideas and ignore yours.
The fact that you have to create a new user name each time to even get people to read your posts should tell you exactly how valued your contributions are.