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righthandman

Member Since 20 Sep 2011
Offline Last Active Yesterday, 01:06 PM

Topics I've Started

Inositol Abolished My Acne, But With Drastic Side Effects

23 October 2014 - 02:38 PM

I won't detail my full acne history here and save that for another thread.

 

I started using myo-Inositol from a health food store, and my skin cleared quickly and dramatically. It cleared on my back, my face, and my chest, even most of my blackheads were gone. At the time I was using many other supplements, I was exercising and adhering to my personal acne diet (no soy, low sugar, emphasize vegetables, etc) so I was unsure of how much Inositol really contributed to the improvement. One by one, I stopped taking supplements, and then slowly I stopped exercising and returned to a junk food diet with lots of Burger King and Ice Cream. I may have had a few small pimples but It still remained clearer than ever. now hold your horses on buying it just yet. At first Inositol improved my mood and energy but then after a week it deteriorated. My side effects included:

-brain fog and short-term memory problems

-anxiety

-shaky hands

-adhd type behavior

-difficulty reading, drawing, writing

 

These were so bad that I could not function as a normal person at work, at school, or in my personal life. I don't think I could live with being that shaky weird guy with beautiful skin.

 

myo-Inositol is complex in that it is converted to Inositol Triphosphate which is a signaling molecule involved in many reactions in the body, and it is also a brain osmolyte which can affect cell pressure in your BRAIN! It is also closely involved with insulin which I suspect is it's mechansism of action in clearing my acne.  If someone asks I can post quite a few studies to back up these statements, or you can search inositol+insulin on google scholar or jstor.org

 

 

Many people use Inositol at super high doses over 10 grams a day to successfully treat conditions like depression and OCD. The women over at soulcysters.net, myfitnesspal.com, and other forums use myo-Inositol & D-Chiro-Inositol to treat PCOS side effects like acne, excess hair growth, abnormal cycles, etc. Also for some it successfully resensitizes their serotonin receptors. However some of us have reactions like mine. My dosage was only around 2-3 grams a day which I brought down to 500mg with no change in side effects.

 

My experience won't necessarilly mirror yours and could be the exception. However please do your research before supplementing!


Vitamin A, Desiccated Thyroid, Sunlight

07 December 2013 - 01:38 PM

I just wanted to write out my new theory here in case anyone is interested. This is totally half baked though. A little pretext first: I found that I became clearer when supplementing with an animal sourced Vitamin A & D (without soybean oil) & eating a sweet potato or some carrots daily, and was getting a decent amount of natural sun exposure as well as going to a tanning salon twice a week. My purpose wasn't to get tan but to stimulate Retinoic acid and its metabolites in the skin. Alternativista posted about it here: 

 

http://www.acne.org/...to-acne/page-11

 

This led me to investigate hypothyroidism as I found out that hypothyroid patients cannot convert beta-carotene to its active vitamin A form. This led me to do more research in which I found out this:

 

http://www.nature.co...s/340653a0.html

and

http://www.ncbi.nlm....cles/PMC364826/

and 

http://www.ncbi.nlm..../pubmed/1331778

 

To sum up, the abstracts explained to me that a deficiency of thyroid hormone, thyroxine, in the body results in a retinoic acid deficiency. This is because the thyroxine accepting hormone receptor and the retinoic acid hormone receptor are similar in shape and can bind to each other in what is known as heterodimerization. The Vitamin A and UV combo worked well for me most of the time but I continued to breakout. (I would like to note here that my acne is moderate now but it was at one point very severe on my face, back, chest, and neck). My new theory that I will attempt is to supplement with natural dessicated porcine thyroid hormone which contains both T3 and T4, supplement with Vitamin A and occasionally eat beta carotene food sources (i also read that eating too much beta-carotene can suppress thyroid function. who knew?) and to also expose myself to uv light in order to stimulate the production of retinoic acid in my skin. Maybe since the thyroid hormone receptors will be in use by my thyroid hormones that I will be supplementing with, my body will be able to better synthesize retinoic acid from my vitamin a intake and sunlight exposure. THis all runs consistent with my philosophy on health and nutrition. In our most prime healthy form, humans would be eating nutrient dense food, would be exposed to constant natural sunlight, and would have a healthy operating thyroid. To me, the correlation between lack of sunllight and my acne is apparent since acne is most commonly found on the face, shoulders, neck, back and chest. These would be the areas most exposed to sunlight in the wild. 


Thyroid, Arachidonic Acid, Beta-Carotene, And More That I Have Learned...

23 November 2013 - 08:34 PM

I just wanted to update anyone interested in holistic methods for acne what I have been doing recently. I learned about Arachidonic Acid (AA) which is highly inflammatory and what Omega 6 is converted to in the body. AA metabolizes into all the inflammatory compounds; especially leukotrienes and prostaglandins. I learned that you need to redirect how your body deals with PolyUnsaturated Fatty Acids (PUFA's) towards the anti-inflammatory compounds. I realize that there is a balance. We already know that Omega 6 or Linoleic Acid and Arachidonic Acid are plentiful in the American diet (found in butter, olive oil, nuts, seeds, any vegetable oils, animal fats) and that lowering Omega 6 while raising Omega 3's is beneficial towards acne or any inflammatory condition. But I have also learned from paleohacks.com that too much PUFA's of any kind can result in acne. So this may be why some people supplement with Fish Oil and find that their acne worsens. They point to rancid oils but it may also be that they need to drastically reduce their Omega 6 intake and only raise their Omega 3 intake slightly like eating a portion of Wild Salmon (emphasis on Wild) every other day. Arachidonic Acid is more inflammatory than Omega 6 (Linoleic Acid) and is therefore best avoided. I learned that it is found extremely high in chicken, egg yolks, pork, and farmed fish. I also learned that it is low in naturally raised chicken and their yolks. Basically the diet that your meat ate is important. Many chickens are fed high soy and grain diets which of course is going to change their tissue composition to make them more inflammatory. I have eliminated egg yolk and chicken with some success. I found that I was eating alot of eggs and chicken as part of my paleo diet and was still breaking out alot. Farmed salmon is extremely high in Arachidonic Acid (AA).

 

I still have acne, there is no doubt about that. I feel as though I am so close to finding a solution because I have been trying for years. The second thing that I have been learning about is Vitamin A and sunshine. There was a previous post by autonomous and also alternativista (both are very knowledgeable and helpful contributors here) that stated that UV light combined with vitamin A intake stimulated retinoic acid production in the skin. Alot of studies have related an overactive gene, i think it is CYP26ai, in acne patients which breaks down retinoic acid faster than it can be produced. Retinoids are directly related to the acne condition. For example, Accutane is a Vitamin A derivative. I noticed that when I have prolonged sun exposure, my acne improves alot. I started to go out in the sun alot and also tanned twice a week, and take a Vitamin A/D supplement sourced from a fish, maybe cod liver and then also eating foods high in beta-carotene, like carrots, sweet potatoes, kale, and spinach. My skin started to do alot better. I found though, that when I stopped my vitamin a supplement but continued to get high amounts of beta-carotene in my diet, my skin started to do worse. I have read that excessive beta-carotene can be inflammatory in the body, especially when you cannot convert it to its active Vitamin A metabolites. I also read that those with hypothyroidism have a harder time converting beta carotene to Vitamin A. This is worse when you consider that most people can't efficiently convert beta-carotene to Vitamin A at all (i think like 4% conversion rate). Also it is important to point out that Beta-carotene supplements are generally not effective. Alot of studies recently have shown they have a negative effect on cancer rates in smokers. I think its much better to get your beta-carotene from whole food sources because it will be more natural and complete instead of isolated and synthesized from lab chemicals. So what my current regimen is to continue to take Vitamin A, about 30,000 IU daily, tan twice a week/get more sun, eat paleo-ish diet, meaning no vegetable oils, chicken, egg yolk, sugar, wheat, dairy. But I will still eat some rice because I get too exhausted on a Low Carb Diet. I am going to eat lots of Wild Canned Salmon, rice, vegetables, coconut oil, garlic etc. I just ordered Dessicated Porcine Thyroid Capsules from Nutri-meds which apparently are not as potent as Syntheroid or Armour or any other prescription thyroid medication. I hope that these thyroid supplements, which are obtainable without a prescription, will be my last push towards clear skin.

 

The reason I suspect hypothyroidism is because of the following:

1. I breakout from any soy products (also any Omega 6's) which suppress the thyroid. 

2. I breakout from raw cabbage and broccoli which are goitrogens and are bad for the thyroid.

3. My acne improved a lot when I supplemented Olive Leaf Extract (OLE). Oleuropein, the active compound in OLE, stimulates thyroid activity surprisingly.

4. I have brain fog, depression, anxiety, lethargy, an inability to lose weight, a white tongue, dandruff, a smelly scalp, and acne. I have read various sources online which states these are general symptoms of hypothyroidism. Though I have never had cold hands or feet which is usually a strong indicator of hypo. There are also alot of symptoms of hypothyroidism and they are very general and I feel as though anyone could potentially self diagnosis themselves as hypo.

 

(Please don't criticize me. I cannot afford a trip to the endocrinologist, and I know for certain that any doctor would not prescribe me a thyroid medication for acne. My self-diagnosis is not meant to teach people anything. I am not a doctor and everything I say here is particular to my situation. Please do your own independent research!)

 

Please feel free to ask me questions or give suggestions! THank You!


Autoimmune Paleo & Pufas

31 August 2013 - 10:54 AM

Hi,

I've been around acne.org for quite some time now and still haven't gotten clear. But I have picked up alot of information about diet, hormones, skin care and more. The first culprit I found for my acne was soy & flax. Both are goitrogenic and also contain high amounts  omega 6's (linoleic acid) and also phytoestrogens. It has always been hard for me to pinpoint which aspect of soy is so bad for my acne. It may be a collective effort. Regardless, I never eat soy or flax as I breakout severely from both.  I have been paleo on & off with some success but never close to what I wanted. Recently I read about a much stricter version of paleo called AI Paleo (autoimmune) which eliminates eggs, nuts, seeds, and nightshades. Thats the gist of it although there are a fewer other things to eliminate. Google it if you are interested. I realized that I ate eggs and nightshades (tomatoes, potatoes, eggplants, and any peppers except black pepper) limitlessly through the whole time I have had acne. The whole nightshade aspect seems strange to me though, aren't we supposed to be eating fruits, vegetables, and tubers? Aren't those the healthiest foods? I have always looked at diet with an evolutionary spin. We didn't eat grains because we couldn't process them, or we didn't eat dairy because cow breast milk is meant for the calf only. These are just assumptions though. So I began to investigate why eggs break some people out. Please don't deny this, as many people on acne.org and also paleohacks.com find that eggs contribute to their acne. But that doesn't mean that eggs break everyone out. Personally I believe egg yolks are super nutritious, but theres alot of debate. In my research I found that egg yolks are super high in arachidonic acid (AA) which is inflammatory, also organ meats and chicken fat. I eat a lot of chicken. I again saw online that some people breakout from eating too much chicken. Arachidonic Acid (AA) is derived from Linoleic Acid (LA), an omega 6, in your body. There is a lot of controversy over how much AA is necessary. Some websites claim that it is the source of all inflammation, whereas others say it is completely healthy in normal amounts. It is known that AA converts into many inflammatory metabolites in the body, some that contribute directly to acne like. These include the 4 series leukotrienes (LTB4, LTC4, LTD4, LTE4). There might be more, please research into it yourself. It is also already known that the Standard American Diet (SAD) is overloaded with omega 6’s which are inflammatory. I find that even canola oil can break me out. Recently I ate half a chicken, and a carton of eggs and I have been breaking out.

 

 

Let me get to the point. To test my theories, I am going to continue with a paleo diet, limiting grains, dairy, sugar, and legumes but I will also cut out eggs, chicken, avocados, organ meats, nuts, seeds palm oil, olive oil, and anything that could have high amounts of Arachidonic Acid or Linoleic Acid. Before, my paleo diet didn’t focus on this aspect, I still ate a lot of eggs, chicken, avocados, and olive oil every day. Basically I am going to try cutting my Omega 6 intake as much as possible. This may seem extreme to some, dietary changes have always been easy for me since I cook my own food. This leaves me to eating beef, fish, coconut, vegetables, and fruit.  To me this seems to run parallel with my evolutionary mindset towards food. The following shows AA and LA content of common foods.

 

http://wholefoodcata...cid/foods/high/

 

http://wholefoodcata...d/foods/high/1/

 

I believe that some intake of Omega 6 is natural, such as that in grass fed meats or wild fish, but maybe our ancestors ate almost none in comparison to what we consume today. I don’t know if there is a name for this diet, but I am ultimately trying to cut my AA and LA intake by a lot while also focusing on other things such as consuming mostly nutrient rich vegetables such as asparagus, sweet potatoes, spinach, lettuce, zucchini and so forth. I don’t want meat or fruit to dominate my diet. 


The Superoxide Theory

19 April 2013 - 04:25 PM

Please read this previous thread for info before commenting:

http://www.acne.org/...o-inflammation/

 

I am confident, after years of dealing with acne that there is one fundamental difference between acne sufferers and those with clear skin. But this idea doesn't dismiss the fact that acne is multifactorial and I am not dismissing healthy eating, exercise, antibiotics, benzoyl peroxide, etc. I believe that all the different manners of treating acne work by affecting one thing but in different ways. I thought at one point that it was DHT, a more potent form of testosterone. Many of you may have read this thread entitled, DHT the sole creator of acne:

 

http://www.acne.org/...reator-of-acne/

 

While I do believe that DHT contributes to acne, I don't think it is what we should be focusing on. I personally use borage oil with lecithin to keep my acne under control. The mechanism here is GLA which inhibits DHT production. But this hasn't cleared my acne completely. I also only masturbate at most twice a week because I know that excessive masturbation/sexual activity can exacerbate acne.

 

My newest theory is that the production of superoxide anions triggers acne. Superoxide dismutase is a "scavenger" of superoxide anions, meaning it destroys the superoxide anions. Either acne sufferers don't produce enough superoxide dismutase in the skin, or we produce too much superoxide anions.

 

http://www.ncbi.nlm....29/?tool=pubmed

 

Vitamin E potently reduces superoxide anion when applied topically. THis may explain why so many benefit from Vitamin E oil. I did a bit of researching and found that there are 8 different isomers of Vitamin E; alpha, beta, gamma, & delta tocopherols and  alpha, beta, gamma, & delta tocotrienols. Most vitamin E's sold are of the tocopherol kind. I found out that the tocotrienol forms are generally higher in antioxidant power:

 

http://www.sciencedi...009912099000272

 

Recently I have applied a full spectrum vitamin E capsule topically making sure to get a significant source of tocotrienols. I do so before bed each night because it leaves my face red during the day. This helped my situation so I continued to research and found this abstract:

 

http://www.ncbi.nlm....pubmed/16972004

 

It basically states that a certain plant known as Chinese Knotweed, Fo-Ti, Fallopia Multiflora, or Polygonum Multiflorum, strongly inhibits the destruction of SOD1. I forgot to mention that SOD1 is superoxide dismutase in its zinc form. The zinc form is the one related to acne. I went to chinatown and found Fo-Ti for very cheap. Its in a pill form which I crush up. I make a mixture with it along with vitamin e from my capsule, some water, and a little bit of hemp oil. I always use hemp oil as it is non comedogenic and has always helped me. These two things together have been tremendously helpful. 

 

The reason I am posting this is to share my knowledge but also to ask for help from fellow acne researchers. I have had, at many points, severe acne. I wasn't able to leave my room in fear of being seen in public. I skipped classes, have missed countless social opportunities, and become severely depressed. Acne holds me back from the person that I want to be and I know when I have a clear face and body, I will embrace life in all its glory. I have tried all diets ranging from sugar free, gluten free, dairy free, raw, vegan, vegetarian, paleo, and wai. I have supplemented with green tea, resveratrol, magnesium, vitamin d, fish oil, iodine, chromium, cinnamon, the list is too long.

 

 

I am trying to find one extract, oil, herb, drug, or vitamin that can be ingested or applied topically that treats my acne by either effectively increasing zinc superoxide dismutase (SOD1) or inhibiting the production of superoxide anions and reactive oxygen species (ROS) in the skin.

 

 So far Fo-Ti and Vitamin E work but not well enough. I want to see if anyone wants to help me out on this theory of mine. Fo-Ti isn't the best solution because its very dark to apply on the skin and you must leave it on, vitamin E makes my skin bright red, and I still have acne. 

 



Here are some promising abstracts/studies involving the antioxidant activities of certain herbs/drugs/vitamins/extracts. I would appreciate it if someone helped by trying one of these and documenting your successes/failures here.

 

 

 

Cocoa polyphenols inhibit phorbol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NF-kappaB and MAPKs in mouse skin in vivo.

 

http://www.ncbi.nlm....pubmed/16614396

"The levels of COX-2 expression induced in mouse skin after 4-h treatment with topical TPA (10 nmol) was also diminished significantly by pretreating CP (40 or 200 mg/kg) for 30 min."

 

 

 

 

Changes in Zinc Levels
and Superoxide Dismutase Activities in the Skin of Acute, Ultraviolet-B- Irradiated Mice After Treatment With Ginkgo Biloba Extract 

 

http://link.springer...ER:80:2:175.pdf

"The Zn levels changed in the same pattern as the SOD activity values. "

 

 

 

Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4).

 

http://www.ncbi.nlm....pubmed/20083859

"The same resveratrol regimen upregulated the mRNA expression of SOD1 and GPx1."

 

 

 

Ozonized sunflower oil reduces oxidative damage induced by indomethacin in rat gastric mucosa http://link.springer...-7034-1?LI=true "It was concluded that cytoprotective effects of OSO in rat gastric mucosa are mediated at least partially by upregulation of the antioxidant system and mainly SOD."

 

 

Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: implication for prevention against inflammation-related carcinogenesis 

http://carcin.oxford.../4/567.full.pdf

"We demonstrated for the first time that the pre-treatment with BITC 40 min prior to each TPA treatment significantly inhibited the number of papillomas per mouse. "

 

 

 

 

Highly galloylated tannin fractions from witch hazel (Hamamelis virginiana) bark: electron transfer capacity, in vitro antioxidant activity, and effects on skin-related cells.

 

http://www.ncbi.nlm....pubmed/18311930

"...we hypothesize that the final putative antioxidant effect of polyphenols may be in part attributed to the stimulation of defense systems by mild prooxidant challenges provided by reactive oxygen species generated through redox cycling."

 

 

 

Sesamol inhibits UVB-induced ROS generation and subsequent oxidative damage in cultured human skin dermal fibroblasts.

 

http://www.ncbi.nlm....pubmed/20697726

"On the other hand, sesamol pretreatment significantly decreased cytotoxicity, intracellular ROS, lipid peroxidation, oxidative DNA damage and apoptotic morphological changes in sesamol-pretreated and UVB-irradiated HDFa cells."

 

 

Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulation.

 

http://www.ncbi.nlm....pubmed/20211546

" Genistein exerted dramatically protective effects on HDFs in a dose-dependent mannerz"