I won't detail my full acne history here and save that for another thread.
I started using myo-Inositol from a health food store, and my skin cleared quickly and dramatically. It cleared on my back, my face, and my chest, even most of my blackheads were gone. At the time I was using many other supplements, I was exercising and adhering to my personal acne diet (no soy, low sugar, emphasize vegetables, etc) so I was unsure of how much Inositol really contributed to the improvement. One by one, I stopped taking supplements, and then slowly I stopped exercising and returned to a junk food diet with lots of Burger King and Ice Cream. I may have had a few small pimples but It still remained clearer than ever. now hold your horses on buying it just yet. At first Inositol improved my mood and energy but then after a week it deteriorated. My side effects included:
-brain fog and short-term memory problems
-adhd type behavior
-difficulty reading, drawing, writing
These were so bad that I could not function as a normal person at work, at school, or in my personal life. I don't think I could live with being that shaky weird guy with beautiful skin.
myo-Inositol is complex in that it is converted to Inositol Triphosphate which is a signaling molecule involved in many reactions in the body, and it is also a brain osmolyte which can affect cell pressure in your BRAIN! It is also closely involved with insulin which I suspect is it's mechansism of action in clearing my acne. If someone asks I can post quite a few studies to back up these statements, or you can search inositol+insulin on google scholar or jstor.org
Many people use Inositol at super high doses over 10 grams a day to successfully treat conditions like depression and OCD. The women over at soulcysters.net, myfitnesspal.com, and other forums use myo-Inositol & D-Chiro-Inositol to treat PCOS side effects like acne, excess hair growth, abnormal cycles, etc. Also for some it successfully resensitizes their serotonin receptors. However some of us have reactions like mine. My dosage was only around 2-3 grams a day which I brought down to 500mg with no change in side effects.
My experience won't necessarilly mirror yours and could be the exception. However please do your research before supplementing!