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Chico Esposito

Member Since 02 Aug 2011
Offline Last Active Yesterday, 06:25 PM

#3469533 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 26 January 2015 - 05:00 PM

I understand why you do it accutanereallysucks, but i find it in poor taste. Lots of the people on this site have spent thousands upon thousands in the hope that they can get a handle on the side effects caused by this drug, yourself included. Charging people that have suffered enough is not fair game as far as i'm concerned. Your a dermatologist, you don't need the money. Any information that can help those suffering with these debilitating side effects should be out in the public domain, especially seeing as the plight of said people is wholly ignored by the medical establishment. The same establishment that caused the problem in the first place.




#3469099 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 22 January 2015 - 07:40 PM

http://liweilab.gene...gi=1592&ti=9606

 

This is the main enzyme responsible for metabolising accutane, is there any way to induce it?




#3468605 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 19 January 2015 - 02:24 PM

I personally wouldn't use the denatured whey because of the retinol content. Rather use n-acetylcysteine, liposomal Vitamin C or alpha lipoic acid...... but fascinating post chung*pao non the less. Also i've read that milk thistle is a potent CYP3A4 enzyme inhibitor, likewise grapefruit juice so it'd be best to stay away from them. Why the use of T4, whats the theory behind that?




#3468562 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 19 January 2015 - 07:41 AM

Modeaa's post on the other page is brilliant. CYP3A4 is the main enzyme used to remove excess retinol and it's involved in the metabolism of All trans retinol and retinoic acid. It a heme enzyme which means it needs iron to be created. Iron also needs copper to metabolise. Vitamin C increases iron uptake as does folate and B12. But the most important thing is iron itself.




#3468392 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 17 January 2015 - 02:51 PM

You guys have been saying how bad you react to vitamin A, to be honest never happened to me after Accutane.

My fatigue and gut problems are at their worst when I'm really stressed about university and job hunting. I do wonder whether it is chronic anxiety or stress which caused all my problems or is it the fact that they caused Accutane to cause me problems. I didn't read the whole thread but i wonder why only some of us are affected by the drug so badly.

 

For a sufferer like me who has been having severe anxiety problems for three years, I do want to know whether I am curing myself in the right way. Is it really Accutane?

 

Colon cleansing doesn't work, it's bogus. The concept of mucoid plaque is also bogus. It's just the Psylium in the product mixed with the charcoal and other bulking ingredients that form those muciod looking things. Actually the whole thing is potentially harmful. It's just a money making scam. The whole idea behind parasite cleanses is also bogus. 

 

Hulda Clarke believed that parasites were the cause of cancer, she thought intestinal flukes made there way to the liver and caused liver cancer, again utter rubbish and 100% scientifically wrong. Same with Moritz and the liver flush.... the stones are olive oil and lemon / grapefruit juice mixed with the epsom salts and a little bit of the apple juice you've been ingesting for days. It's totally fake. 

 

Theres nothing wrong with colon hydrotherapy, it'll remove a lot waste from the colon and make you feel better. But it's not long lasting. It may help active crohns or colitis if you do a colon hydrotherapy session then replenish the gut with aloe and probiotic rich foods, but it's not going to cure you. If it's intestinal and you know that 100% then you'd be better off adding raw sauerkraut and other healthy plant based probiotics to your diet. Eating a very clean diet, looking at raw foods, blending smoothies and so forth. But if i was you i'd pay for the dance classes.




#3467277 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 09 January 2015 - 08:41 AM

Accutane healing - 2nd link

Accutane repair - 1st link

Accutane - recover 5th link

Roaccutane repair - 1st link

Roaccutane chronic side effects - 6th link

Roaccutane healing - 3rd link

Healing Roaccutane side effects -7th link

 

Every one of those word search shows this site and this topic on the first page. 




#3466132 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 31 December 2014 - 05:38 PM

Have a Happy New Year everyone. 




#3465301 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 25 December 2014 - 08:06 AM

Hope everyone has a good christmas. Thinking of you all and praying for a cure someday soon.




#3457204 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 23 October 2014 - 02:26 PM

Chico youve been on this forum since its inception. By now you would have gained much experience.

Can you tell me what supplements have helped and what you take currently if any?

 

Cheers

 

I don't take any supplements anymore. I've taken them all, i mean you name it and i've taken it, but i don't see things in that way anymore. There was a time were it was "just let me find that one supplement that cures this" that was my approach, i've spent tens of thousands on supplements, it just doesn't work like that. You take something, the power of placebo, you think it's working, then suddenly it stops and you go back to the way it was before.

 

There are broadly two types of people here, ones the flat out react to vitamin A in food and people that don't....i'm in the former. Vitamin A in the form of retinol is poison to my body. The best advice i can give for those people is you must avoid ALL forms of retinol completely. I still eat kale and spinach and high beta carotene foods but egg yolk, butter, milk, cheese, meat, fish - i don't touch it, you can't heal if you don't remove it, you'll just keep adding to the toxicity.

 

Now you might be the type that doesn't react to vitamin A, either way stay away from cod liver oil, just eat what you normally eat. When i was 1-3 years post accutane i could eat whatever i wanted, i didn't react to vitamin A, but the more i ate, the worse it got, now it's 11 years post accutane and i cannot eat it at all, it accumulates.

 

So my advice would be sort out your diet, eat fruits, vegetables, soak nuts and seeds, eat quinoa, lentils, beans etc. Understand nutrition, dry skin brush, yoga, weightlifting, lymph based herbal teas, kidney herbs, echinacea, cleavers,  i drink a tea from Dr Stuart called skin purify it has nettles, red clover, burdock root, dandelion root, drink lots of water. I have a vitamix, i make 1-2 green smoothies a day, i strongly recommend that above juicing for the fiber benefits. Just healthy lifestyle choices really, no isolated supplements, just foods.

 

If you've got dry skin try natural moisturisers like Jojoba oil, grape seed oil, coconut oil, apply argan oil to your hair, explore them. Hope that answers your question timatron, obviously it's not for everyone but that's my honest opinion.




#3456428 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 17 October 2014 - 11:49 AM

Firstly i'm not irrational, the only time i've been irrational on here has been one time to Crank and i've apologised to him for that. Secondly I don't object to other peoples theories, in fact i like reading tryingtohelp and Dubya's posts. I'm interested in the methylation and homeopathic imprint theories, i like reading anonyy's post's and what he has to say on the matter.  

 

I'm just sceptical when someone says "hey i've cured myself by applying grape seed oil once" and then everyone goes out and buys grape seed oil, and then it's "hey i took 15mg of biotin and all my side effects like aching joint's, dry skin, hair loss, it all went away" and then everyone goes out and buys biotin and so on....

 

It's a perpetual loop where it's about buying supplements and not about understanding the root cause. Most of us have hypervitaminosis A side effects, most of us do not disclose the length and severity of side effects we have, so when someone cures something, what have they cured? and what did they have in the first place? 




#3455408 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 10 October 2014 - 01:51 PM

A deficiency of vitamin b12 or folate doesn't cause a reaction to eating foods with any retinol in it, nor does a slow methylation pathway cause aching creaking joints, or exfoliative cheilitis of the lips that crack and bleed at night without vaseline. What we're talking about here is a condition of toxicity not deficiency.

 

Taking B12 or folate is not going to suddenly awaken the liver into purging the toxicity. Nor is taking D3 or K2 going to do anything to the side effects in the short or long term. What Anonyy's talking about is terrain modification of the body, what your talking about is supplement cure alls and you can ask virtually any of us what's the net result of all the supplements we've taken and it'll probably be close to zero. I've taken D3 for nearly 2 years, i've taken vitamin K2 in the form you talk about, i've taken b complex and isolated b12 in really high amounts, did any of them work? no. Did they cost a lot of money? yes.

 

Unless there is a study on 100 people with post accutane side effects ranging from mild to severe in a double blind placebo setting with a cure then i'm not interested because they aren't relevant to us. You have to understand that we are the real 'blank generation' just like Richard Hell sang about. There is no foundation (like ALS) set up in our honour researching a cure for us, you either turn your back on the allopathic community and go it blind or go back to them and get the same results you've always gotten.




#3454793 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 06 October 2014 - 10:42 AM

Durian rider is a complete sociopath / psychopath and thinks everyone that doesn't follow Doug Graham is a quack. The man has about the same amount of intelligence as a plank of wood and bans people from his charlatan site at the first consideration of eating meat, or doing something he doesn't 100% agree with. He charges people hundreds of dollars for a single skype session informing them to eat more banana's, the man is the very definition of charlatan.  He's also been known to send death threats to defectors of his ideology and harassed prominent paleo youtuber’s into getting restraining orders taken out against him, such is the level of abuse. He certainly doesn't deserve to be held up as any sort of truth gauge unless the gauge itself, was a mentalism gauge.

 

Robert Morse sells herbs at exorbitant prices, he doesn't live the lifestyle he preaches, but his information is actually very good. Don't get me wrong, he can be perceived as a charlatan as well and i suppose there is an aspect of that, like with all healers in the sense that he's selling his own product, but i think his intentions are very much noble.

 

About the vitamin A thing, maybe, possible certainly, but then again why would the skin condition completely go away when fasting?

 

As for the ad hominem attacks on your person i do apologise for that, i apologise for discrediting your character, that wasn't called for. i don't however apologise for calling it bs and it does irritate me that this site is used as a 'cannabinoid' research centre, but then again people are probably fed up of my long winded diatribes about accutane, so i can see it both way's. Will you accept my apology Crank?




#3454439 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 03 October 2014 - 07:26 PM

Ha witnessing: 'tryingtohelp2014' vs. 'anonny' brings about a profound sense of deja vu.

I've grown tired of bickering about who's right or wrong, but this thread definitely needs sub-sections so we can debate our hypotheses with like-minded individuals. Rather than concomitantly discussing topics as diverse as methyl regulation as well as eating more apples...

Anyway, now that I've got a functioning internet connection once again I'll post up my 1 month review of RSO in the next couple of days.

Of note, when I'm doing the most exercise I'm feeling at my best. Ahhh the idiosyncrasies, so frustrating in their diversity. 

 

 

Why don't you create a Accutane side effects RSO sub forum, to flog your bs cannabis oil and take your little minion's with you, so the people that actually have problems beyond semi erect penises can debate with each other rather than some Rick Simpson sales man trying to peddle his wears on everyone like it's the gospel truth for 100% of the people.




#3454290 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 02 October 2014 - 01:49 PM

 

 

You don't understand what is detoxification. Detoxification is eliminative. You explain me how some methylation issue within the brain (caused by a congested environment btw) will drain the lymph from the kidneys?

 

Listen, this stuff is not stored in your brain... or your kidney.  thats #1.    you have to ELIMINATE IT from the body by whatever means necessary(synthetic or otherwise.)  The kidney is  just one elimination route.... but treating the kidney or lymph nodes wont mobilize the metabolite thats stored in the fat or the liver.  you have to deal with the enzymes and genes that deal with the liver detoxification pathways imo.

 

i think #1 you have to get to a state where the drug metabolite is circulating again... either thru fasting or extreme exercise, and then hit the metabolite with everything to eliminate it.  That being all of the active forms of B  along with other supportive minerals that deal SPECIFICALLY with your bodies WELL KNOWN methylation processes.

 

 

And to say you dont care about the medical studies.... why the @#!%$ am i even arguing with you?????

 

I don't know where you got the methylation idea from but accutane's removed through glucuronidation, it's bound to a glucuronic acid molecule and removed principally via the kidney's, so again anonyy actually knows what he's talking about. Granted it's also removed in the bile as well but glucuronidation is the process of making a fat soluble compound more water soluble so it can be excreted via that pathway.

 

Secondly the idea that it's stored in the liver is also wrong, accutane is not retinol, retinol is stored in the liver, retinoic acid is end chain, it doesn't store in the liver, categorically, 100%. One of the things anonyy talks about is drinking kombucha, kombucha is the only known food source of glucuronic acid, it also inhibits the cleaving of glucuronic acid via beta glucuronidase enzymes, these enzymes break the bond between the glucuronic acid molecule and the toxin and force the toxin back into the system, kombucha helps prevent this.

 

I believe you about it being stored in the body, i have very similar experiences whilst fasting to your own and i'm in complete agreement with you there, others don't believe it, that's fine we can have differing opinions on things, it's not the end of the world. The lymphatic system is very important when dealing with accutane side effects though, you shouldn't poo-poo that idea, the lymph transports fat soluble vitamins to and from the cell, accutane is a fat soluble vitamin so it's transported through the lymph, the lymph removes fat soluble compounds, the lymph has a lot to play in this, anonyy knows.

 

In fact anonyy deserves more respect than he's being given around here, just because he talks about the bigger picture doesn't mean he's not referencing intuitively the concepts that you are talking about like detoxification pathways, enzymes, etc, he just looks at it more expansively.

 

 

if its not stored in the liver, where is it being stored...because we both know its stillin us...in one form or another.... is it stored in the fat itself...is it constantly being recycled?

 

i read what he said about calcium d glucorinate.... you would have to  take 30,000 mgs to have any effect.  the amount of glucuronic acid in kombucha is negligible 



One of the things Roaccutane (or Accutane or isotretinoin or 13-cis retinoic acid) does is to raise the gene expression of the enzyme glycine N-methyltransferase. This enzyme normally limits the ratio of SAMe to SAH in the methylation cycle. When the activity of this enzyme is increased, the ratio of SAMe to SAH is decreased, and this causes a methylation deficit, so that the many methyltransferase reactions in the body are downregulated. I think this is the connection to ME/CFS. Over the past few years, I have heard from several people who developed ME/CFS after being treated with Accutane. I don't know why this happens to some people, but not to most. I'm aware of one case in which testing indicates that glycine N-methyltransferase has remained upregulated even years after Roaccutane treatment was ended. I don't know why. 

Glycine N-methyltransferase is normally inhibited by 5L-methyl tetrahydrofolate, which is a form of folate used in the methylation treatments. If glycine N-methyltransferase is responsive to it, as it normally is, the methylation treatment should downregulate it. In the case I refer to, this doesn't seem to work, and I don't know why. Perhaps there is a genetic polymorphism in glycine N-methyltransferase in some people that causes it to be unresponsive to methylfolate.

Best regards,

Rich

 

 

 

It's stored in the fat and no it's not constantly recycled, the only time it comes out is during juice fasts or water fasts when you lose body weight really quickly, the fat is being used as energy and it can come out into the circulation, hence the feelings of being on accutane again (dry skin, cracked lips, flushed skin). From my experience it's much better off being left there, detoxifying the lymph is important, if it gets moved it goes to the lymph, remember all cells, even fat cells take in nutrients from the blood and excrete toxins via the lymph.




#3454050 Repairing the long-term damage from Accutane

Posted by Chico Esposito on 30 September 2014 - 08:15 PM

You don't understand what is detoxification. Detoxification is eliminative. You explain me how some methylation issue within the brain (caused by a congested environment btw) will drain the lymph from the kidneys?

 

Listen, this stuff is not stored in your brain... or your kidney.  thats #1.    you have to ELIMINATE IT from the body by whatever means necessary(synthetic or otherwise.)  The kidney is  just one elimination route.... but treating the kidney or lymph nodes wont mobilize the metabolite thats stored in the fat or the liver.  you have to deal with the enzymes and genes that deal with the liver detoxification pathways imo.

 

i think #1 you have to get to a state where the drug metabolite is circulating again... either thru fasting or extreme exercise, and then hit the metabolite with everything to eliminate it.  That being all of the active forms of B  along with other supportive minerals that deal SPECIFICALLY with your bodies WELL KNOWN methylation processes.

 

 

And to say you dont care about the medical studies.... why the @#!%$ am i even arguing with you?????

 

I don't know where you got the methylation idea from but accutane's removed through glucuronidation, it's bound to a glucuronic acid molecule and removed principally via the kidney's, so again anonyy actually knows what he's talking about. Granted it's also removed in the bile as well but glucuronidation is the process of making a fat soluble compound more water soluble so it can be excreted via that pathway.

 

Secondly the idea that it's stored in the liver is also wrong, accutane is not retinol, retinol is stored in the liver, retinoic acid is end chain, it doesn't store in the liver, categorically, 100%. One of the things anonyy talks about is drinking kombucha, kombucha is the only known food source of glucuronic acid, it also inhibits the cleaving of glucuronic acid via beta glucuronidase enzymes, these enzymes break the bond between the glucuronic acid molecule and the toxin and force the toxin back into the system, kombucha helps prevent this.

 

I believe you about it being stored in the body, i have very similar experiences whilst fasting to your own and i'm in complete agreement with you there, others don't believe it, that's fine we can have differing opinions on things, it's not the end of the world. The lymphatic system is very important when dealing with accutane side effects though, you shouldn't poo-poo that idea, the lymph transports fat soluble vitamins to and from the cell, accutane is a fat soluble vitamin so it's transported through the lymph, the lymph removes fat soluble compounds, the lymph has a lot to play in this, anonyy knows.

 

In fact anonyy deserves more respect than he's being given around here, just because he talks about the bigger picture doesn't mean he's not referencing intuitively the concepts that you are talking about like detoxification pathways, enzymes, etc, he just looks at it more expansively.