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Green Gables

Member Since 06 Jun 2011
Offline Last Active Yesterday, 11:32 PM

Topics I've Started

Acne And Insulin Problems

05 August 2014 - 06:31 PM

This was started with brenmc in mind, but I'd like to hear from everyone else.

 

Are any of you type 1 or type 2 diabetic?

 

How about pre-diabetic or insulin resistant?

Insulin resistance — also called syndrome X or metabolic syndrome— is so pervasive today that we evaluate nearly every woman who visits our clinic to determine her level of risk. Most are taken aback when they learn they either already have insulin resistance syndrome (or as I call it pre-pre diabetic) or are well on their way to developing it. Experts estimate that 25% of all Americans suffer from insulin resistance. We believe the percentage is much higher among perimenopausal women.

 

Because insulin is one of the “major” hormones, it’s also impossible for your body to balance its “minor” hormones (estrogen, progesterone and testosterone among them) until your insulin metabolism is balanced first. To put it simply, if you have hot flashes and you are insulin resistant, it’s going to be nearly impossible to cure the hot flashes without first healing the insulin resistance. Cortisol is also a “major” hormone – to understand it’s role in hormonal balance, read our related articles on adrenal fatigue.

 

The "symptoms" of insulin resistance are not well defined. However:

 

Insulin resistance is a clinical feature of type 2 diabetes mellitus and metabolic syndrome. In the early stages of insulin resistance, symptoms may not be apparent but when type 2 diabetes or metabolic syndrome develop symptoms may include:

 

A raised blood sugar level that may cause increased thirst (polydipsia), frequent excretion of large amounts of urine (polyuria) and increased hunger (polyphagia). In addition, there may be weight gain or weight loss.
Weakness and unexplained fatigue.
Difficulty in concentrating and poor mental stamina - An individual may be sleepy and drowsy during the day time. This could be caused by insulin resistance or by nightly awakenings triggered by the need to urinate. Sleepiness is more pronounced after a meal that is rich in carbohydrates.
Overweight or obesity - Consuming large amounts of carbohydrates can lead to insulin resistance and individuals with the condition may be overweight or obese. The weight gained due to insulin resistance is usually difficult to lose. Typically, the fat is stored around the abdominal organs.
Excess carbohydrates in the diet may also cause other symptoms such as intestinal bloating, flatulence, constipation, diarrhea, nausea and vomiting.
High blood levels of cholesterol and triglycerides. These increases may not cause overt symptoms but in, severe cases, fatty deposits around the eyes may manifest.
Dark skin patches may be visible on parts of the neck. This is called acanthosis nigricans. Dark patches may also be present on the elbows, knuckles knees or armpits.
The hyperglycemia seen in insulin resistance may also cause frequent genital infections, such as thrush.
Raised blood pressure.

 

 

Also, Paleo, primal, or otherwise lower-carb diets do not always solve insulin resistance. The research is in flux. I have seen studies published that outright contradict each other. Some claim that the only way to "naturally" improve insulin resistance is to eat low carb. Some have found that in some people low carb at a certain point actually makes insulin resistance worse.

 

Maybe that's why for me, after years of eating Paleo, generally living a healthy lifestyle ,and exercising like a beast, my fasting blood glucose is still on the high end of normal. But who knows.

 

I definitely think there is a connection between how our body handles insulin / glucose and our skin, though. 

 

 

Also to brenmc, are you on Metformin? This article compares berberine to Metformin and came out in favor of berberine. http://www.tahomacli...erine-diabetes/


Adrenal Vs. Ovary Androgens

15 July 2014 - 11:13 AM

I was reading some endocrinology research in AMA which specifically talks about acne and elevated androgens / androgen sensitivity in women.

 

It says you can have an androgen problem initiating from the adrenals or the ovary, or both.

 

Glucocorticoids are best for adrenal androgen suppression (spironolactone)

"[For adrenal androgen suppression] At this time, spironolactone is the most useful anti-androgen."

 

Birth controls with anti- or low androgenic progestins are best for ovary androgen suppression (e.g. Yaz, Diane)

 

Sometimes you need both.

 

The article also confirms what I've been saying since I started spironolactone: that androgen changes occur very slowly. It recommends a minimum of 2 years of anti-androgen therapy. It says that after 2 years with good results, some people can slowly taper off their dose in 6 month phases (so if you clear on 100mg...imagine cutting down to 75mg after 2.5years, then 50mg after 3 years, then 25mg after 3.5 years...), but recurrence is common, and some will need lifetime anti-androgen therapy. 

 

More interesting tidbits from the article

 

  • Ketoconazole (anti-fungal) and cimetidine (a h2 blocker) have anti-androgenic effects. 
  • "Seborrhea occurs soon after androgen levels rise; consequently, acne is usually the first androgenic skin manifestation."
  • "The acne process begins when androgen action increases sebum production by the 
    pilosebaceous unit. Without androgen action on the sebaceous gland, acne does not occur."
  • "Both ovary and adrenal glands secrete androgens, and it is important for diagnosis and treatment selection to determine the relative contribution of each to circulating androgen levels in an individual patient. Both are important as sources of andro- 
    gens, but the proportion of androgens secreted by each varies in individual women. Ovarian pre-dominance is suggested by young age, oligomenorrhea, obesity, and more severe hirsutism. Because there are many exceptions to these generalizations, the relative ovarian and adrenal contributions should be determined by suppression testing. Tes-tosterone and androstenedione can be of either ori-gin, but DHEAS is almost exclusively adrenal. However, when DHEAS is elevated along with other androgens, it cannot be assumed that the ad-renal is the source of the other androgens. "

Spironolactone Generics With Pictures And What Pharmacy

14 July 2014 - 10:51 AM

Found this page the other day that has pictures of all the generics of spironolactone. If you click on "view images and details" under the picture that looks your pill, you can find out the ingredients and manufacturing details.

 

Reply with the specific number your pills are branded with and the pharmacy you get them from.

 

Rite-Aid

Qualitest / White / 58 81 V

 

Kmart

Amneal / Yellow / AN 514

 

Canadian Pharmacy?

Teva-Spiro / Peach / N | N on the side

 

Walgreens

Amneal / Yellow / AN 515


Favorite Sunscreen For Wear Under Makeup

05 July 2014 - 09:17 PM

What sunscreens have you found work well under makeup?

 

30 SPF or higher only please. 

 

 


Can I Have Acne From Low Progesterone / Estrogen Dominance?

20 December 2013 - 03:07 PM

Now, I'm going to preface this by saying that I have dabbled in progesterone myself (not for acne specifically, but for other health issues), and some of the literature out there for "low progesterone / estrogen dominance" makes sense to me, even though estrogen dominance is not recognized by mainstream medicine.

 

HOWEVER, there is very little scientific evidence out there showing that low progesterone = acne or that high estrogen = acne. Yes, some books and a lot of naturopaths say that it does. Yes, some people have anecdotally experienced clearance of acne from estrogen dominance protocols (and I applaud their success).

 

I've been bamboozled by it all a little myself, until you realize that most of these naturopaths basically claim that progesterone fixes every possible symptom of any health problem you could have.

 

So I'm writing this post to explore what literature is (or isn't) out there that actually supports "low progesterone / estrogen dominance = acne."

 

Basically...what is progesterone? 

 

Progesterone is a precursor in the steroid hormone cascade. It can be converted to testosterone and estrogen as needed, among other things. 

 

 

 

Image171.gif

 

 

 

So, as progesterone is also a precursor to testosterone/estrogen, if your progesterone is too high, progesterone itself can potentially cause testosterone/estrogen hormonal imbalances down the steroid hormone path. 

 

Similarly, though, if progesterone is too low, it can cause a number of deficiency problems because progesterone is needed to complete various pathways. Could possibly a deficiency of progesterone lead to a hormonal imbalance that causes acne? Yes, I suppose it could. However I couldn't find any studies showing that particular outcome.

 

What does progesterone do for the skin?

 

Let's first go through what all the hormones do for the skin. 

 

Estrogen:

  • Thins sebum secretions
  • Reduces size and activity of sebaceous glands 
  • Increases activity of hyaluronidase (related to hyaluronic acid, related to skin moisture content)

 

As far as acne production goes, thinning sebum and reducing sebaceous activity is a HUGE positive.

 

Testosterone:

  • Increase sizes and activity of sebaceous glands
  • Increases rate of cell turnover in the basal layer which thickens the skin around the sebaceous duct

Increasing sebum production is bad when it comes to acne, and so is thickening the skin around the sebaceous duct because it makes a sebum plug -> acne more likely. If you've forgotten how that links together, see this image:

 

 

Acne-pimples.jpg

 

Progesterone

 

Okay, but what does progesterone do? The short answer is that the direct relationship between progesterone and the skin has not been studied much. The skin has progesterone receptors. Their action is mostly unknown.

 

It does seem to have some anti-inflammatory effects on the skin. Not necessarily directly related to acne, but conceivably could have an effect since acne involves inflammation:

 

- Progesterone regulates lipid peroxidation (free radical cell damage) 

- Progesterone regulates lysosomal activity (sort of like garbage disposal for your cells)

 

Again, is that directly related to the sebum plug -> acne chain in the picture? No, but some anti-inflammatory action on the skin could still help.

 

- May temporarily reduce sebum secretion in females

 

There is evidence that anti-androgens may help in the treatment of acne vulgaris. We therefore performed a double-blind trial to assess the effect of topically applied progesterone on sebum excretion rate. Thirty-eight patients took part in the trial which was for 3 months. The preparation had no etfect in males. However, a signiticant reduction in sebum excretion rate was found in females, the etfect being maximal at the end of the second month. There was a significant loss of effect at the end of the third month and this was not related to deterioration of the progesterone preparation.

 

I got bad side effects on anti-androgens like spironolactone or saw palmetto. Does progesterone have anti-androgenic effects?

 

Natural progesterone (and SOME types of synthetic progestins) has a high affinity for 5 alpha reductase, which means that it competes for 5 alpha reductase with testosterone. Why is this a good thing? Because testosterone uses 5 alpha reductase to convert to dihydrotestosterone (DHT) which has been implicated as a potent factor in acne. 

 

I really want to stress this point, because some who use progesterone claim that "reducing androgenic activity doesn't help my acne." BY USING PROGESTERONE you are exerting an anti-androgenic influence on your body!

 

Perhaps progesterone's particular mechanism worked well for you and spironolactone's didn't. But please realize that we are still attacking the same thing here, which is an ANDROGENIC problem -> acne. 

 

Can HIGH progesterone cause acne?

 

We are talking about natural progesterone here. (Many synthetic progestins, have been shown over and over again to have androgenic activity.)

 

- Progesterone can increase sebaceous hyperplasia (at least in rats -- see Haskin's study)

- Progesterone as effective as testosterone in stimulating sebaceous glands (at least in the elderly -- see Smith's study)

- Progesterone CREATED acne in females

 

However, these studies have been countered by other studies (Strauss and Kligman) that say that natural progesterone is largely "sebaceous gland neutral." So the jury is still out on this one.

 

How does progesterone reduce estrogen?

 

PROGESTERONE has long been considered an antagonist of oestrogen action1. The delicate balance and interactions between these ovarian hormones are essential for many reproductive functions. Early studies in chick oviducts and uteri of rats and mice have shown that the simultaneous administration of progesterone and oestrogen resulted in inhibition or modification of oestrogen-induced growth of these target organs2–5. One possible mechanism by which progesterone could be antagonistic to oestrogen is by suppressing the quantity of cytoplasmic oestrogen receptor. It is generally held that the mechanism by which oestrogen, O, stimulates uterine growth depends on the binding of O to cytoplasmic receptors, Rc, to form RCO complexes6. These RCO complexes are translocated to nuclear sites where they probably stimulate nuclear events that cause the uterus to grow7. Translocation and nuclear accumulation of receptor–oestrogen complexes, RnO, are accompanied by a concomitant decrease in the quantity of Rc (ref. 8). During the period when Rc is reduced, the uterus is insensitive to additional exogenous oestrogen9. Gradually Rc is replenished by processes which may involve reutilisation and/or resynthesis8. Work from our laboratory indicates that the mechanism of action of non-steroidal oestrogen antagonists resides in their inability to stimulate the replenishment of the cytoplasmic oestrogen receptor, Rc, thereby rendering oestrogen responsive tissues less sensitive to oestrogen10,11. The possibility that progesterone might also act as an oestrogen antagonist by reducing the amount of oestrogen Rc has been suggested12,13. In this report, we demonstrate that progesterone does decrease the quantity of oestrogen receptors by interfering with the replenishment of Rc and that this decrease results in a reduced sensitivity of uterine tissue to oestrogen.

 

Does high estrogen cause acne?

 

I could not find any studies linking high estrogen levels to acne. If anything, most research indicates that while excessively high estrogen has other side effects (such as weight gain), estrogen overall is extremely beneficial for acne. 

 

 

Does lowering androgenic activity or raising estrogenic activity change the menstrual cycle, via spironolactone? 

 

The reason spironolactone is indicated for messing with the menstrual cycle is, as far as research has shown, because of its PROGESTOGENIC effect. Not to get huffy on this, but people keep stating that "lowering androgenic activity" or "raising estrogen" changes the menstrual cycle, and then point to spironolactone as proof. It is the progestogenic activity that is most likely to blame (citation). Also think: you can have a progestin-only birth control pill. Why? Because progesterone is ultimately what controls the cycle. 

 

Another point here, is that Finasteride, which has been often compared to spiro, is very powerful anti-androgen but does not have progestogenic effects. As such, Finasteride does not interfere with the menstrual cycle (citation). So again, it is not the testosterone or the estrogen that really messes with your periods, it is progesterone. This is also why some doctors recommend cycling spironolactone for patients who are very sensitive to the weak progestogenic effect. 

 

Conclusion

 

So from my (admittedly limited) study...

 

High estrogen does not cause acne.

Low progesterone does not cause acne (at least not directly).

High progesterone can potentially cause acne. 

Progestogenic effects are responsible for major menstrual cycle changes. 

Androgens can cause acne.

Progesterone's anti-acne mechanism is primarily its anti-androgenic action. 

If one is progesterone deficient, progesterone may potentially solve health problems (possibly including acne) via its general ability to create and regulate other hormones.