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Member Since 31 Dec 2010
Offline Last Active Jul 02 2014 02:12 PM

Topics I've Started

Acne Is A Disease Of Western Civilisation Probably Mediated Through Mtorc1 Protein

07 March 2012 - 03:36 AM

The purpose of this paper is to highlight the endocrine signaling of Western diet, a fundamental environmental factor involved in the pathogenesis of epidemic acne. Western nutrition is characterized by high calorie uptake, high glycemic load, high fat and meat intake, as well as increased consumption of insulin- and IGF-1-level elevating dairy proteins. Metabolic signals of Western diet are sensed by the nutrient-sensitive kinase, mammalian target of rapamycin complex 1 (mTORC1), which integrates signals of cellular energy, growth factors (insulin, IGF-1) and protein-derived signals, predominantly leucine, provided in high amounts by milk proteins and meat. mTORC1 activates SREBP, the master transcription factor of lipogenesis. Leucine stimulates mTORC1-SREBP signaling and leucine is directly converted by sebocytes into fatty acids and sterols for sebaceous lipid synthesis. Over-activated mTORC1 increases androgen hormone secretion and most likely amplifies androgen-driven mTORC1 signaling of sebaceous follicles. Testosterone directly activates mTORC1. Future research should investigate the effects of isotretinoin on sebocyte mTORC1 activity. It is conceivable that isotretinoin may downregulate mTORC1 in sebocytes by upregulation of nuclear levels of FoxO1. The role of Western diet in acne can only be fully appreciated when all stimulatory inputs for maximal mTORC1 activation, i.e., glucose, insulin, IGF-1 and leucine, are adequately considered. Epidemic acne has to be recognized as an mTORC1-driven disease of civilization like obesity, type 2 diabetes, cancer and neurodegenerative diseases. These new insights into Western diet-mediated mTORC1-hyperactivity provide a rational basis for dietary intervention in acne by attenuating mTORC1 signaling by reducing (1) total energy intake, (2) hyperglycemic carbohydrates, (3) insulinotropic dairy proteins and (4) leucine-rich meat and dairy proteins. The necessary dietary changes are opposed to the evolution of industrialized food and fast food distribution of Westernized countries. An attenuation of mTORC1 signaling is only possible by increasing the consumption of vegetables and fruit, the major components of vegan or Paleolithic diets. The dermatologist bears a tremendous responsibility for his young acne patients who should be advised to modify their dietary habits in order to reduce activating stimuli of mTORC1, not only to improve acne but to prevent the harmful and expensive march to other mTORC1-related chronic diseases later in life.


Natural mTORC1 inhibitors are: EGCG, Resveratrol, Curcumin

New Antimicrobial Peptide Could Be an Excellent Therapeutic Agent for Acne Vulgaris

02 August 2011 - 11:52 AM

Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. Cathelicidin-BF has been purified from the snake venoms of Bungarus fasciatus and it is the first identified cathelicidin antimicrobial peptide in reptiles. In this study, cathelicidin-BF was found exerting strong antibacterial activities against Propionibacterium acnes. Its minimal inhibitory concentration against two strains of P. acnes was 4.7 µg/ml. Cathelicidin-BF also effectively killed other microorganisms including Staphylococcus epidermidis, which was possible pathogen for acne vulgaris. Cathelicidin-BF significantly inhibited pro-inflammatory factors secretion in human monocytic cells and P. acnes-induced O(2) (.-) production of human HaCaT keratinocyte cells.

Source: http://www.ncbi.nlm....pubmed/21789223

New study explains the possible connection between isotretinoin and IBD

24 March 2011 - 02:53 AM

New study explains the possible connection between isotretinoin and inflammation of the colon in people suffering from celiac disease.

It seems that apart from regular blood tests, liver enzymes and sugar level people will also have to check if they don't suffer from celiac disease, because otherwise they might end up with inflammatory bowel disease induced by 13-cis-retinoic acid.

When the researchers upregulated the levels of intestinal IL-15 to levels comparable with those found in human celiac disease patients, they found that the mice began to exhibit signs of celiac disease, such as villous atrophy, when exposed to gluten antigens. Adding retinoic acid to the intestinal environment caused an exaggeration of this effect.

Writing in the journal Nature, Jabri and colleagues say: "These observations caution against the use of vitamin A and retinoic acid for the treatment of autoimmunity and inflammatory intestinal disorders associated with high levels of IL-15.

"Indeed, a causal relationship between retinoids used in the treatment of acne and inflammatory bowel disease has been implicated in a subset of patients."

I might add that many people don't even know that they are suffering from celiac disease, because their symptoms are very mild. Maybe that's why a lot of isotretinoin takers who developed IBD during the course claim that they never had any previous colon issues.

If other recent studies continue to show such "interesting" data on isotretinoin, then soon u will have to do 20 different tests before u will be allowed to "safely" take the drug.

Source: http://www.medwire-n...evelopment.html