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Member Since 31 Dec 2010
Offline Last Active Jul 02 2014 02:12 PM

Topics I've Started

New Antimicrobial Peptide Could Be an Excellent Therapeutic Agent for Acne Vulgaris

02 August 2011 - 11:52 AM

Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. Cathelicidin-BF has been purified from the snake venoms of Bungarus fasciatus and it is the first identified cathelicidin antimicrobial peptide in reptiles. In this study, cathelicidin-BF was found exerting strong antibacterial activities against Propionibacterium acnes. Its minimal inhibitory concentration against two strains of P. acnes was 4.7 µg/ml. Cathelicidin-BF also effectively killed other microorganisms including Staphylococcus epidermidis, which was possible pathogen for acne vulgaris. Cathelicidin-BF significantly inhibited pro-inflammatory factors secretion in human monocytic cells and P. acnes-induced O(2) (.-) production of human HaCaT keratinocyte cells.

Source: http://www.ncbi.nlm....pubmed/21789223

New study explains the possible connection between isotretinoin and IBD

24 March 2011 - 02:53 AM

New study explains the possible connection between isotretinoin and inflammation of the colon in people suffering from celiac disease.

It seems that apart from regular blood tests, liver enzymes and sugar level people will also have to check if they don't suffer from celiac disease, because otherwise they might end up with inflammatory bowel disease induced by 13-cis-retinoic acid.

When the researchers upregulated the levels of intestinal IL-15 to levels comparable with those found in human celiac disease patients, they found that the mice began to exhibit signs of celiac disease, such as villous atrophy, when exposed to gluten antigens. Adding retinoic acid to the intestinal environment caused an exaggeration of this effect.

Writing in the journal Nature, Jabri and colleagues say: "These observations caution against the use of vitamin A and retinoic acid for the treatment of autoimmunity and inflammatory intestinal disorders associated with high levels of IL-15.

"Indeed, a causal relationship between retinoids used in the treatment of acne and inflammatory bowel disease has been implicated in a subset of patients."

I might add that many people don't even know that they are suffering from celiac disease, because their symptoms are very mild. Maybe that's why a lot of isotretinoin takers who developed IBD during the course claim that they never had any previous colon issues.

If other recent studies continue to show such "interesting" data on isotretinoin, then soon u will have to do 20 different tests before u will be allowed to "safely" take the drug.

Source: http://www.medwire-n...evelopment.html