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Member Since 31 Dec 2010
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#3382328 Acne Is A Disease Of Western Civilisation Probably Mediated Through Mtorc1 Pr...

Posted by VanceAstro on 13 September 2013 - 09:23 AM

VanceAstro, do you have experience with reducing mTORC1 and noting the results of doing so or did you just find and post this paper abstract?


Mtorc1 & acne connection is still just a working hypothesis (I am not aware of any clinical trials that would either confirm or reject it empirically). I also don't think it's possible to significantly downregulate mTORC1 with OTC supplements, although highly bioavailable nano-curcumin is probably worth a try (to my knowledge there is only one such product on the market right now). Unfortunately, the most potent curcumin, resveratrol and EGCG derivatives are still under investigation in clinical trials (but it has been shown - in vivo - that they inhibit the AKT-mTOR pathway).

#3382281 Repairing the long-term damage from Accutane

Posted by VanceAstro on 13 September 2013 - 04:19 AM

It's been 4 years since I've finished my low dose isotretinoin course and I'm still losing sleep over persistent side effects, namely:


- bright stools

- statorrhea (inability to digest fatty foods)

- constipation

- stomach gurgling

- constant gas

- malabsorbtion

- occasional diarrhea

- weakness

- dry mouth & eyes (obviously)

- cold hands & feet (thyroid?)


Bright stools and steatorrhea may suggest a pancreatic disorder (steatorrhea is a common manifestation of exocrine pancreatic insufficiency - "In order for someone to develop exocrine pancreatic insufficiency, 90 percent of the pancreas has to be destroyed,”). Great perspective for someone in his 20's.


It is important to emphasize that - while on Isotretinoin - my lab tests were usually normal (apart from a very slight increase in bilirubin, which normalized after 2 weeks). Other liver parameters (ALT, AST) were even better than before I started Isotretinoin (probably due to a strict diet and liver supplements).


Anyway, I'm planning to do a CT scan and Endoscopic ultrasound to check the pancreas, but I'm afraid that I already know the results.

#3223299 Acne Is A Disease Of Western Civilisation Probably Mediated Through Mtorc1 Pr...

Posted by VanceAstro on 07 March 2012 - 03:36 AM

The purpose of this paper is to highlight the endocrine signaling of Western diet, a fundamental environmental factor involved in the pathogenesis of epidemic acne. Western nutrition is characterized by high calorie uptake, high glycemic load, high fat and meat intake, as well as increased consumption of insulin- and IGF-1-level elevating dairy proteins. Metabolic signals of Western diet are sensed by the nutrient-sensitive kinase, mammalian target of rapamycin complex 1 (mTORC1), which integrates signals of cellular energy, growth factors (insulin, IGF-1) and protein-derived signals, predominantly leucine, provided in high amounts by milk proteins and meat. mTORC1 activates SREBP, the master transcription factor of lipogenesis. Leucine stimulates mTORC1-SREBP signaling and leucine is directly converted by sebocytes into fatty acids and sterols for sebaceous lipid synthesis. Over-activated mTORC1 increases androgen hormone secretion and most likely amplifies androgen-driven mTORC1 signaling of sebaceous follicles. Testosterone directly activates mTORC1. Future research should investigate the effects of isotretinoin on sebocyte mTORC1 activity. It is conceivable that isotretinoin may downregulate mTORC1 in sebocytes by upregulation of nuclear levels of FoxO1. The role of Western diet in acne can only be fully appreciated when all stimulatory inputs for maximal mTORC1 activation, i.e., glucose, insulin, IGF-1 and leucine, are adequately considered. Epidemic acne has to be recognized as an mTORC1-driven disease of civilization like obesity, type 2 diabetes, cancer and neurodegenerative diseases. These new insights into Western diet-mediated mTORC1-hyperactivity provide a rational basis for dietary intervention in acne by attenuating mTORC1 signaling by reducing (1) total energy intake, (2) hyperglycemic carbohydrates, (3) insulinotropic dairy proteins and (4) leucine-rich meat and dairy proteins. The necessary dietary changes are opposed to the evolution of industrialized food and fast food distribution of Westernized countries. An attenuation of mTORC1 signaling is only possible by increasing the consumption of vegetables and fruit, the major components of vegan or Paleolithic diets. The dermatologist bears a tremendous responsibility for his young acne patients who should be advised to modify their dietary habits in order to reduce activating stimuli of mTORC1, not only to improve acne but to prevent the harmful and expensive march to other mTORC1-related chronic diseases later in life.


Natural mTORC1 inhibitors are: EGCG, Resveratrol, Curcumin

#3082823 Repairing the long-term damage from Accutane

Posted by VanceAstro on 16 May 2011 - 07:27 AM

QUOTE (lamarr1986 @ May 15 2011, 05:16 PM) <{POST_SNAPBACK}>
We do know that omega 3 and vitamin A are closely related in many ways and likely interact with each other

Before you start to give advices over the internet, first make sure to learn what is the difference between cod liver oil and EPA/DHA Omega-3. *moderator edit*

QUOTE (FutureScarless @ May 16 2011, 05:53 AM) <{POST_SNAPBACK}>
Edit // Okay, yeah, I read the whole thread and my suggestion to see a Naturopath still stands. And as for the Omega-3, as Lamarr said, it supposedly acts like Accutane in some ways. So basically, your body doesn't need it because it has already had enough! I've also read that Omega-3 holds Accutane in your body even longer.

*moderator edit* What are you talking about? Omega-3 like accutane? Omega-3 holds accutane?  lol.gif Where are you getting this from?  No seriously, I didn't laughed that hard since ages  lol.gif

I repeat again: the only thing you should avoid while taking isotretinoin is Vitamin A rich cod liver oil which could cause hypervitaminosis A. It has nothing to do with EPA/DHA Omega-3 fish oil. EPA/DHA Omega-3 fish oil is even suggested while taking accutane because it can alleviate many isotretinoin-induced side effects [dry eyes, joint paints, increased cholesterol and more]. Fish oil supplementation is also able to produce durable reductions in fasting triglyceride levels despite ongoing treatment with antiretroviral therapy—a finding that is similar to those from studies of omega-3 fatty acid for the treatment of isotretinoin- and etretinate-induced hypertriglyceridemia".

QUOTE (FutureScarless @ May 16 2011, 05:53 AM) <{POST_SNAPBACK}>
Take an Omega-6 (like Borage Oil, or Primrose Evening Oil might be better) instead.

*moderator edit* Do you know that the intake of Omega-6 [N-6 PUFA] is linked with the developement of inflammatory bowel disease? Inflammatory bowel disease is also the most dangerous adverse effect linked with isotretinoin. Unlike Omega-6, Omega-3 intake can reduce the probability of inflammatory bowel disease by 77 percent. You can read about it HERE

I urge everyone to read studies i posted below, *moderator edit*


#3082299 Repairing the long-term damage from Accutane

Posted by VanceAstro on 15 May 2011 - 09:45 AM

QUOTE (IndigoRush @ May 15 2011, 09:37 AM) <{POST_SNAPBACK}>
I think I recall, but I want to know why...
Many people advise to TAKE Omega 3, or whatever fish oil.
I'm not sure it was making things worse... so in what way are you saying it's bad? Is it meant to contain vitamin A or something?

Omega-3 intake is suggested in many isotretinoin studies [especially Omega-3 fish oil with vitamin E]. Apart from many others [scientifically proven] benefits, EPA/DHA acids [found in omega-3] can reduce joint pain caused by isotretinoin.

Omega-3 Fish oil can also lower cholesterol increased by isotretinoin intake:


Cod liver oil is a different story. You obviously shouldn't take Cod liver oil that contains vitamin A.

It seems that Lamar don't know the difference between EPA/DHA omega 3 fish oil and cod liver oil rich in vitamin A.


Bonus: http://www.ehow.com/...s-accutane.html

#3082293 Repairing the long-term damage from Accutane

Posted by VanceAstro on 15 May 2011 - 09:35 AM

QUOTE (lamarr1986 @ May 13 2011, 07:54 AM) <{POST_SNAPBACK}>
Anyway PLEAsE stop the omega 3 immediately, fish oils and cod liver oil is toxic to us post tane!