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Member Since 31 Dec 2010
Offline Last Active Jul 02 2014 02:12 PM

Posts I've Made

In Topic: Repairing the long-term damage from Accutane

14 September 2013 - 10:17 AM

As far as I can see it would make sense to do PERT (pancreatic enzyme replacement theraphy) at a low dose and then see who the body reacts. I am much less afraid of the idea of having to constantly supplement enzymes instead of UDCA


Sounds reasonable.

In clinical practice, the diagnosis of Pancreatic enzyme insufficiency is usually based on an assessment of the patient’s clinical state, a self-report of bowel movements and weight loss in adults, or failure to thrive in children. Pancreatic enzyme replacement therapy (PERT) can be trialled, and symptom improvement would support a diagnosis of Pancreatic enzyme insufficiency.




PS. Have you had a colonoscopy?

In Topic: Repairing the long-term damage from Accutane

14 September 2013 - 09:08 AM

VanceAstro, I have never encountered someone whose symptoms so closely matched my own.


Indeed, there are not many people with our symptoms (couldn't find any on the internet and I've searched extensively), so maybe we got hit by some rare, idiosyncratic reaction or maybe we are suffering from a well-known - albeit undiagnosed - disease. Anyhow, I suspect "primarily painless chronic pancreatits" (although very rare; "several studies have reported painless forms in approximately 10% - 20% of well-diagnosed series"), because Non-Pancreatic Exocrine Insuficiency (steatorrhea caused by Celiac Disease, Crohn’s disease, Ulcerative Colitis, Hypercalcemia etc.) is probably less common than Pancreatic Exocrine Insuficiency (steatorrhea caused by continuous inflammation and degradation of pancreas - toxically induced).“Obstructive” pancreatitis that recovers following elimination of the obstruction is also possible. Other rare causes of chronic pancreatitis include,hyperlipidemia, pancreas divisum, hyperparathyroidism, gas-trectomy".




The online literature points - in most cases - to a very strong connection between fat malabsorbtion, steatorrhea and pancreatic disorder. Also, it is well known that pancreas can suffer extensively from prolonged exposure to certain drugs (vide Isotretinoin). But of course, this is just a sheer speculation and the only way to be sure is to perform CT scan and/or Endoscopic ultrasound (because lipase and amylase levels can be completely normal). Also, "Chronic pancreatitis has an annual incidence of about one person per 100x2009.gif000 in the United Kingdom and a prevalence of 3/100x2009.gif000" (ergo, "painless chronic pancreatits" is probably even rarer). But If I had to bet, I'd bet on Inflammatory Bowel Disease or Chronic Pancreatitis - both of these diseases can occur simultaneously (sic!).


I know one thing for sure - Isotretinoin destroyed my health.




In Topic: Acne Is A Disease Of Western Civilisation Probably Mediated Through Mtorc1 Pr...

13 September 2013 - 09:23 AM

VanceAstro, do you have experience with reducing mTORC1 and noting the results of doing so or did you just find and post this paper abstract?


Mtorc1 & acne connection is still just a working hypothesis (I am not aware of any clinical trials that would either confirm or reject it empirically). I also don't think it's possible to significantly downregulate mTORC1 with OTC supplements, although highly bioavailable nano-curcumin is probably worth a try (to my knowledge there is only one such product on the market right now). Unfortunately, the most potent curcumin, resveratrol and EGCG derivatives are still under investigation in clinical trials (but it has been shown - in vivo - that they inhibit the AKT-mTOR pathway).

In Topic: Repairing the long-term damage from Accutane

13 September 2013 - 05:32 AM

It seems like what has helped Joseph and me will probably help you too. I have used supplements to support the pancrease in the past, they helped but they only worked while taking them. I believe you can cure pretty much anything in your body. With regards to the pancreas you got to raise insulin sensitivity. ALA, cinnamon, chromium picolinate may all help here.


I've finished 4 bottles of Na-RALA, but unfortunately didn't noticed any improvement. I will try pancreatic (digestive) enzymes, and if they help, then it probably means that my pancreas is significantly damaged (I really hope it's not chronic pancreatitis eusa_pray.gif ).

In Topic: Repairing the long-term damage from Accutane

13 September 2013 - 04:19 AM

It's been 4 years since I've finished my low dose isotretinoin course and I'm still losing sleep over persistent side effects, namely:


- bright stools

- statorrhea (inability to digest fatty foods)

- constipation

- stomach gurgling

- constant gas

- malabsorbtion

- occasional diarrhea

- weakness

- dry mouth & eyes (obviously)

- cold hands & feet (thyroid?)


Bright stools and steatorrhea may suggest a pancreatic disorder (steatorrhea is a common manifestation of exocrine pancreatic insufficiency - "In order for someone to develop exocrine pancreatic insufficiency, 90 percent of the pancreas has to be destroyed,”). Great perspective for someone in his 20's.


It is important to emphasize that - while on Isotretinoin - my lab tests were usually normal (apart from a very slight increase in bilirubin, which normalized after 2 weeks). Other liver parameters (ALT, AST) were even better than before I started Isotretinoin (probably due to a strict diet and liver supplements).


Anyway, I'm planning to do a CT scan and Endoscopic ultrasound to check the pancreas, but I'm afraid that I already know the results.